• Official Full Name
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
  • Background
  • This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]
  • Synonyms
  • SLC9A3R1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; regulatory cofactor of Na(+)/H(+) exchanger; ezrin-radixin-moesin binding phosphoprotein-50; ezrin-radixin-moesin-binding phosphoprotein 50; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1;
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SLC9A3R1
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 1, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SLC9A3R1 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SLC9A3R1 Protein
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus SLC9A3R1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SLC9A3R1 Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SLC9A3R1
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SLC9A3R1
Source (Host):Species:Human
Product nameRecombinant Human SLC9A3R1 293 Cell Lysate

Involved Pathway

SLC9A3R1 involved in several pathways and played different roles in them. We selected most pathways SLC9A3R1 participated on our site, such as PDGFR-beta signaling pathway, Thromboxane A2 receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
PDGFR-beta signaling pathway
Thromboxane A2 receptor signaling

Protein Function

SLC9A3R1 has several biochemical functions, for example, PDZ domain binding, beta-2 adrenergic receptor binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A3R1 itself. We selected most functions SLC9A3R1 had, and list some proteins which have the same functions with SLC9A3R1. You can find most of the proteins on our site.
Related Protein
Function PDZ domain binding
Related Protein NSF; GRIK5; SNTA1; Fzd4; DLG4; SNTB1; CIT; GRASP; PLEKHA2; ACVR2A
Function beta-2 adrenergic receptor binding
Related Protein BDKRB2; NEDD4; SLC9A3R1; GNAS; PDE4D
Function beta-catenin binding
Related Protein TBL1X; DVL3; HDAC6; APC2; CBY1; TBL1XR1; PTPRK; FAM123B; AXIN1; LEF1
Function chloride channel regulator activity
Related Protein SGK3; SGK2; BSND; SGK2A; SLC9A3R1; CHRNA7; SGK1; SGK2B
Function dopamine receptor binding
Related Protein SLC9A3R1; CLIC6
Function growth factor receptor binding
Related Protein SRC; FYN; APP; SLC9A3R1
Function phosphatase binding
Related Protein MAST2; SPRED1; PPP1R27; PPARA; CSRNP2; SH2D4A; ELL; CRY1; TPRN; SH3GL1
Function protein binding
Related Protein C1S; HIRA; RPS6KA1; LRRC8C; Kitl; PER3; TARBP2; TUT1; XRCC5; BHLHE40
Function protein complex binding
Related Protein KAT6B; CRIPT; ARRB2; Apba1; PTK2B; NDUFA9; CEBPA; GIT2; ABP1; CDKN1A
Function protein complex scaffold
Related Protein AKAP1; CAV3; PKP2; AXIN1; WWC1; WWC2; MAGI1; C9orf142; AKAP6; CAV2
Function protein self-association
Related Protein AGTR1A; NKX3-1; ABCD3; SVIP; SHANK3; LDB1; RYR2; BCL10; PABPN1; ADAM8
Function receptor binding
Related Protein PTPRD; ADAM10; NPFFL; HLA-E; F2; FGG; HLA-G; ACOT2; MAP7; ECH1

Interacting Protein

SLC9A3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A3R1.

SLC9A3R1 Related Articles

Dudakovic, A; Camilleri, ET; et al. Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:52-62(2015).
Dudakovic, A; Evans, JM; et al. Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:28783-28791(2013).