SLC9A3R1 Protein, solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1


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Official Full Name solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Background This gene encodes a sodium/hydrogen exchanger regulatory cofactor. The protein interacts with and regulates various proteins including the cystic fibrosis transmembrane conductance regulator and G-protein coupled receptors such as the beta2-adrenergic receptor and the parathyroid hormone 1 receptor. The protein also interacts with proteins that function as linkers between integral membrane and cytoskeletal proteins. The protein localizes to actin-rich structures including membrane ruffles, microvilli, and filopodia. Mutations in this gene result in hypophosphatemic nephrolithiasis/osteoporosis type 2, and loss of heterozygosity of this gene is implicated in breast cancer.[provided by RefSeq, Sep 2009]
Synonyms SLC9A3R1; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1; EBP50; NHERF; NHERF1; NHERF-1; NPHLOP2; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Na+/H+ exchange regulatory co-factor; regulatory cofactor of Na(+)/H(+) exchanger; ezrin-radixin-moesin binding phosphoprotein-50; ezrin-radixin-moesin-binding phosphoprotein 50; solute carrier family 9 isoform A3 regulatory factor 1; solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 1;
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SLC9A3R1-1694HCL Recombinant Human SLC9A3R1 293 Cell Lysate HEK293 N/A
    Human SLC9A3R1-28223TH Recombinant Human SLC9A3R1 Wheat Germ N/A
    Human SLC9A3R1-2912H Recombinant Human Solute Carrier Family 9 (Sodium/Hydrogen Exchanger), Member 3 Regulator 1, His-tagged E.coli His
    Mouse SLC9A3R1-15530M Recombinant Mouse SLC9A3R1 Protein Mammalian Cell His
    Rat SLC9A3R1-5587R Recombinant Rat SLC9A3R1 Protein Mammalian Cell His
    Cynomolgus Monkey SLC9A3R1-938C Recombinant Cynomolgus SLC9A3R1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque SLC9A3R1-4317R Recombinant Rhesus monkey SLC9A3R1 Protein, His-tagged Mammalian Cell His
    Chicken SLC9A3R1-1566C Recombinant Chicken SLC9A3R1 Mammalian Cell His
    Zebrafish SLC9A3R1-11982Z Recombinant Zebrafish SLC9A3R1 Mammalian Cell His

    SLC9A3R1 involved in several pathways and played different roles in them. We selected most pathways SLC9A3R1 participated on our site, such as PDGFR-beta signaling pathway, Thromboxane A2 receptor signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC9A3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PDGFR-beta signaling pathway GRB10; SNX15; SLC9A3R1; SLA; DOK1
    Thromboxane A2 receptor signaling ARR3; ADRBK2; SLC9A3R1

    SLC9A3R1 has several biochemical functions, for example, PDZ domain binding, beta-2 adrenergic receptor binding, beta-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC9A3R1 itself. We selected most functions SLC9A3R1 had, and list some proteins which have the same functions with SLC9A3R1. You can find most of the proteins on our site.

    Function Related Protein
    PDZ domain binding CIT; TBC1D10A; DLG4; MAP2K2; CRIPT; GRIK2; GNG12; CXADR; SNTA1; KCNJ4
    beta-2 adrenergic receptor binding BDKRB2; NEDD4; SLC9A3R1; PDE4D; GNAS
    beta-catenin binding DACT3; AXIN2; RORA; PXN; CDH24; BCL9; CALCOCO1; LZIC; AXIN1; SMAD3
    chloride channel regulator activity SLC9A3R1; CHRNA7; SGK3; BSND; SGK2B; SGK2; SGK1; SGK2A
    dopamine receptor binding CLIC6; SLC9A3R1
    growth factor receptor binding SRC; FYN; APP; SLC9A3R1
    phosphatase binding MAPK3; KIAA0649; WNK1; TSC2; CSRNP2; PPP1R27; TPRN; DLG1L; KLRAQ1; PPARA
    protein binding CNIH4; RAB35; DDIT3; RHOBTB3; ELL; MAP3K1; PSTPIP1; LIN7A; CSRNP1; GTSE1
    protein complex binding TMED10; STRN; PPFIA2; SLC9A3R1; PPP1R9B; SH2B3; RPAIN; DAG1; AP2B1; KRT8
    protein complex scaffold PKP2; CAPN3; TELO2; ISCU; SLC9A1; SLC9A3R2; CHCHD3; ITSN1; WWC2; CAV1
    protein self-association CTSB; ACHE; DVL2; AGTR1B; ZFP639; CNTN2; CBR2; TMEM190; NKX3-1; SVIP
    receptor binding F7; EDA; NPPA; CD2; CADM2A; PSPN; ANG; LEPROT; FGF20A; FGF20B

    SLC9A3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC9A3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC9A3R1.


    Dudakovic, A; Camilleri, ET; et al. Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells. JOURNAL OF CELLULAR PHYSIOLOGY 230:52-62(2015).
    Dudakovic, A; Evans, JM; et al. Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation. JOURNAL OF BIOLOGICAL CHEMISTRY 288:28783-28791(2013).

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