• Official Full Name
  • STEAP family member 4
  • Background
  • The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • STEAP4; STEAP family member 4; TNFAIP9, tumor necrosis factor, alpha induced protein 9; metalloreductase STEAP4; FLJ23153; STAMP2; TIARP; six transmembrane prostate protein 2; sixTransMembrane protein of prostate 2; tumor necrosis factor, alpha-induced p
Source (Host):HEK293Species:Human
Product nameRecombinant Human STEAP4 Protein, MYC/DDK-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STEAP family member 4, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STEAP4, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STEAP4 Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STEAP4 Protein
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STEAP4
Source (Host):Species:Human
Product nameRecombinant Human STEAP4 293 Cell Lysate

Protein Function

STEAP4 has several biochemical functions, for example, cupric reductase activity, ferric-chelate reductase (NADPH) activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STEAP4 itself. We selected most functions STEAP4 had, and list some proteins which have the same functions with STEAP4. You can find most of the proteins on our site.
Related Protein
Function cupric reductase activity
Related Protein STEAP2; STEAP4; STEAP3
Function ferric-chelate reductase (NADPH) activity
Related Protein STEAP4; STEAP2; STEAP3
Function metal ion binding
Related Protein ZFP143; FYCO1; MARCH11; ITGAX; GTSF1; ATP2B4; CSHL1; ACSM1; GYG1; HIC1L

Interacting Protein

STEAP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STEAP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of STEAP4.

STEAP4 Related Articles

Grunewald, TGP; Bach, H; et al. The STEAP protein family: Versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions. BIOLOGY OF THE CELL 104:641-657(2012).
Tanaka, Y; Matsumoto, I; et al. Six-transmembrane epithelial antigen of prostate4 (STEAP4) is a tumor necrosis factor alpha-induced protein that regulates IL-6, IL-8, and cell proliferation in synovium from patients with rheumatoid arthritis. MODERN RHEUMATOLOGY 22:128-136(2012).