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TRADD

Official Full Name

TNFRSF1A-associated via death domain
Overview

Apoptosis mediated by death factors like FasL and TNF-alpha involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) c
Synonyms

TRADD; TNFRSF1A-associated via death domain; tumor necrosis factor receptor type 1-associated DEATH domain protein; Hs.89862; TNFR1-associated death domain protein; tumor necrosis factor receptor-1-associated protein; tumor necrosis factor receptor type 1 associated death domain protein; MGC11078;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TRADD-3383H	Recombinant Human TRADD protein, His-tagged	E.coli	His	1-312 aa	$319 / 25ug
Human	TRADD-29977TH	Recombinant Human TRADD, His-tagged	E.coli	His		Inquiry
Human	TRADD-826HCL	Recombinant Human TRADD 293 Cell Lysate	HEK293	N/A		Inquiry
Human	TRADD-4420H	Recombinant Human TRADD protein, GST-tagged	E.coli	GST	1-312aa	Inquiry
Human	TRADD-6657H	Recombinant Human TRADD Protein (Met61-Leu297), N-His tagged	E.coli	N-His	Met61-Leu297	Inquiry
Human	TRADD-3384H	Recombinant Human TRADD protein, His-tagged	E.coli	His	Met61~Leu297	$298 / 10ug
Mouse	Tradd-1415M	Recombinant Mouse Tradd protein, His & T7-tagged	E.coli	His/T7	Ser21~Leu259 (Accession # Q3U0V2)	Inquiry
Rat	Tradd-1416R	Recombinant Rat Tradd protein, His & T7-tagged	E.coli	His/T7	Asp24~Glu261 (Accession # D3ZZC5)	Inquiry
Zebrafish	TRADD-9147Z	Recombinant Zebrafish TRADD	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
TRADD Related Articles
TRADD Related Research Area

TRADD involved in several pathways and played different roles in them. We selected most pathways TRADD participated on our site, such as NF-kappa B signaling pathway, Sphingolipid signaling pathway, Apoptosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRADD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
NF-kappa B signaling pathway	MAP3K14;BIRC2;LTA;CXCL12;TNFRSF13C;RELA;LTB;IRAK4;XIAP
Sphingolipid signaling pathway	RELA;PTEN;ABCC1;PPP2R2C;RAC1;MAPK12;SGPP1;SGMS2;MAPK11
Apoptosis	CTNNB2;DSG2;DSG1;IRF2A;CASP2;HIST1H1E;CASP6;CASP3A;DYNLL2
RIG-I-like receptor signaling pathway	IKBKB;NT5C3;IFNPHI3;MAPK9;OTUD5;DHX58;Ifna15;MAPK14A;MAPK12A
TNF signaling pathway	FOS;MAP2K4;CFLAR;MAPK13;CREB5;TRAF2;RPS6KA5;MMP3;TRADD
Adipocytokine signaling pathway	PRKAA1;TRAF2;POMC;PPARA;ACSL3;LEP;MAPK8;CPT1B;PRKAG3B
Tuberculosis	TGFB2;IRAK2;Pla2r1;MAPK3;NOS2;HLA-DRB5;RAB7A;PPP3R1;PMAP-36
Hepatitis C	BRAF;PDPK1;PIK3CB;IRF7;PPP2R1B;IFNAR1;CLDN14;IFNA13;CLDN15
Epstein-Barr virus infection	MAPK10;MAPK8;PSMD7;ENTPD8;POLR2J2;TBPL2;YWHAG;HLA-DQA1;HSPA6
Viral carcinogenesis	PIK3CD;GTF2E1;RBL1;GTF2H1;NRAS;BAK1;VAC14;HIST1H2BI;CREB5

TRADD has several biochemical functions, for example, binding, bridging, death domain binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRADD itself. We selected most functions TRADD had, and list some proteins which have the same functions with TRADD. You can find most of the proteins on our site.

Function	Related Protein
binding, bridging	TRADD;PDCD6;GAS6
death domain binding	TRADD;CRADD;DAPL1;DAP1B;DAP;RIPK1
identical protein binding	SETX;FXR2;ASS1;TTR;DYNLT1;KHDC1A;PRPF19;PAK2;FUS
kinase binding	PPP1R9B;UBQLN1;CHIA;NTRK1;PTPN22;TNFAIP3;CTNNB1;TRIP6;PER3
protein binding	EXOSC2;MLST8;HSPA13;LGALS6;KMT2E;COMMD10;TBCEL;ALKBH4;EIF5A
protein complex binding	NR0B2;LAMB3;MYSM1;IGBP1;FADD;PCSK2;PDZK1;NASP;RXRA
signal transducer activity	TAAR12E;GNAQ;COPS2;CHRM5A;TAS2R120;OLFCJ1;OLFR1013;STAT3;OLFR508
tumor necrosis factor receptor binding	TNF;FASLG;TNFSF10L;TNFSF10L3;TNFSF10L4;TRADD;TRAP1;ERAP1;TNFSF13

TRADD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRADD here. Most of them are supplied by our site. Hope this information will be useful for your research of TRADD.

TNFRSF1A; TRAF2

Hu, R; Du, QM; et al. Agonist antibody activates death receptor 6 downstream signaling involving TRADD recruitment. FEBS LETTERS 588:401-407(2014).

Hirsch, B; von der Wall, E; et al. RIP1 expression is necessary for CD30-mediated cell death induction in anaplastic large-cell lymphoma cells. LABORATORY INVESTIGATION 93:677-689(2013).

Apoptosis Adaptor Proteins

RIG-I-like Receptors

Adaptor Proteins

Adaptor Proteins in the Akt Pathway