ube4b
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  • Official Full Name
  • ubiquitination factor E4B
  • Background
  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms
  • UBE4B; ubiquitination factor E4B; ubiquitination factor E4B (homologous to yeast UFD2) , ubiquitination factor E4B (UFD2 homolog, yeast); ubiquitin conjugation factor E4 B; E4; KIAA0684; UBOX3; UFD2; homologous to yeast UFD2; UFD2A-III/UBE4B-III splice i
Cat.#:UBE4B-3552HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UBE4B, His-tagged
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Cat.#:UBE4B-3553HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human UBE4B, GST-tagged
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Cat.#:UBE4B-9713ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UBE4B
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Cat.#:UBE4B-556HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UBE4B 293 Cell Lysate
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Involved Pathway

UBE4B involved in several pathways and played different roles in them. We selected most pathways UBE4B participated on our site, such as Protein processing in endoplasmic reticulum, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein processing in endoplasmic reticulum
UBE2D2L; ATF4; NPLOC4; RNF185; HSP70; SEC24D; CAPN2A; CALR; DNAJB1; EIF2AK2
Ubiquitin mediated proteolysis
UBA7; PIAS4A; TCEB1B; RFWD2; FBXW11; ITCH; UBE2A; WWP2; ANAPC1; NHLRC1

Protein Function

UBE4B has several biochemical functions, for example, enzyme binding, ligase activity, ubiquitin-ubiquitin ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE4B itself. We selected most functions UBE4B had, and list some proteins which have the same functions with UBE4B. You can find most of the proteins on our site.
Function
Related Protein
Function enzyme binding
Related Protein RXRA; TARBP2; BRCA1; UBE2L3; PPP3CB; TMBIM6; PARP1; EHHADH; WWOX; PHKG1
Function ligase activity
Related Protein MDM2; MARCH4; TRIM50; UBE2F; ZFP91; RNF126; STUB1; RANBP2; KCNG4; TRIM37
Function ubiquitin-ubiquitin ligase activity
Related Protein UBE4B; PPIL2; AMFR; UBE2K; ANAPC11; RBX1; PRPF19; STUB1; UBOX5

Interacting Protein

UBE4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE4B here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE4B.
ATXN3; ESR1; VAV2; Nsfl1c; EGFR; CDKN2A; UBXN1