Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional;activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and;deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that;specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating;enzyme which lies in a gene cluster on chromosome Xp11.23.
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Burkhart, RA; Peng, Y; et al. Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival. MOLECULAR CANCER RESEARCH 11:901-911(2013).