• Official Full Name
  • tryptophan rich basic protein
  • Background
  • This gene encodes a basic nuclear protein of unknown function. The gene is widely expressed in adult and fetal tissues. Since the region proposed to contain the gene(s) for congenital heart disease (CHD) in Down syndrome (DS) patients has been restricted to 21q22.2-22.3, this gene, which maps to 21q22.3, has a potential role in the pathogenesis of Down syndrome congenital heart disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • WRB; tryptophan rich basic protein; tryptophan-rich protein; CHD5; Congenital heart disease 5 gene; Congenital heart disease 5 protein; FLJ51808; Tryptophan rich protein, congenital heart disease 5 protein; OTTHUMP00000069044; OTTHUMP00000069046; OTTHUMP00000109172; OTTHUMP00000165173
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse WRB Protein
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat WRB Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken WRB
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish WRB
Source (Host):Species:Human
Product nameRecombinant Human WRB 293 Cell Lysate

WRB Related Articles

Young, MT; Beckmann, R; et al. Red-cell glycophorin A-band 3 interactions associated with the movement of band 3 to the cell surface. BIOCHEMICAL JOURNAL 350:53-60(2000).
Poole, J; Banks, J; et al. Glycophorin A mutation Ala65 -> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wr(b) expression: direct evidence for GPA band 3 interaction necessary for normal Wr(b) expression. TRANSFUSION MEDICINE 9:167-174(1999).