Active Native Human a-Macroglobulin

• Cat.No.: a-Macroglobulin-535H
• Product Overview: Native Human a-Macroglobulin was purified from human plasma.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: alpha-2-Macroglobulin, also known as α2-macroglobulin and abbreviated as α2M and A2M, is a large plasma protein found in the blood. It is produced by the liver, and is a major component of the alpha-2 band in protein electrophoresis.
• Form: Lyophilized from 0.02 M Tris, 0.13 M glycine, pH 8.0, and 0.08 M trehalose
• Bio-activity: This product is a preparation of the intact protein with proteolytic inhibitory activity. One mg of protein will inhibit a minimum of 10 mg of trypsin with an activity of 10,000 BAEE units/mg protein.
• Molecular Mass: mol wt ~720 kDa (four glycoprotein subunits)
• Purity: ≥98% (SDS-PAGE)
• Applications: Inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin sequence, the macroglobulin rearranges and traps the protease.
• Notes: Plasma from each donor has been tested and found negative for antibody to HIV-1/HIV-2, antibody to HCV and HbSAg.
• Storage: The lyophilized powder is stable for at least 2 years when stored at -20 °C.