ADCY5

  • Official Full Name

    adenylate cyclase 5

  • Overview

    This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
  • Synonyms

    ADCY5; adenylate cyclase 5; adenylate cyclase type 5; AC5; AC 5; ADCY 5; Adenylate cyclase type V; Adenylyl cyclase 5; ATP pyrophosphate lyase 5; OTTHUMP00000215640; OTTHUMP00000215641; OTTHUMP00000215642; OTTHUMP00000215643; ATP pyrophosphate-lyase 5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCY5-6927H Recombinant Human ADCY5 protein, His & T7-tagged E.coli His/T7 Gly167~Glu385 (Accession # O95622)
Human ADCY5-329H Recombinant Human ADCY5 Protein, GST-tagged Wheat Germ GST
Human ADCY5-0374H Recombinant Human ADCY5 Protein (Gly167-Ile385), N-His-tagged E.coli N-His Gly167-Ile385
Mouse Adcy5-3177M Recombinant Mouse Adcy5, GST-tagged E.Coli or Yeast GST 1262
Rat ADCY5-518R Recombinant Rat ADCY5 Protein Mammalian Cell His
Rat ADCY5-174R-B Recombinant Rat ADCY5 Protein Pre-coupled Magnetic Beads HEK293
Rat ADCY5-174R Recombinant Rat ADCY5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rabbit ADCY5-3176R Recombinant Rabbit ADCY5, GST-tagged E.Coli or Yeast GST 1264
Zebrafish ADCY5-7665Z Recombinant Zebrafish ADCY5 Mammalian Cell His
Chicken ADCY5-6199C Recombinant Chicken ADCY5 Mammalian Cell His
  • ADCY5 Related Signal Pathway

ADCY5 involved in several pathways and played different roles in them. We selected most pathways ADCY5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ADCY5 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY5 itself. We selected most functions ADCY5 had, and list some proteins which have the same functions with ADCY5. You can find most of the proteins on our site.

Function Related Protein

ADCY5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY5.

  • Q&As
  • Reviews

Q&As (15)

Ask a question
Is Adcy5 protein only found in humans? 07/12/2021

No, Adcy5 protein is found in many different organisms, including mammals, birds, reptiles, fish, and even some invertebrates. It plays a conserved role in regulating cAMP levels within cells, suggesting that it has been evolutionarily conserved for its critical role in cellular signaling.

Can targeting Adcy5 be used to treat cancer? 11/01/2020

Yes, targeting Adcy5 is a potential strategy for treating some types of cancer. Overexpression of Adcy5 has been observed in several cancer types, including breast, prostate, and pancreatic cancer. Inhibiting Adcy5 activity may help to slow the growth and spread of cancer cells.

Are there any drugs that target Adcy5 for ADHD treatment? 06/05/2020

There are no drugs specifically designed to target Adcy5 for ADHD treatment, but stimulant medications like methylphenidate and amphetamines indirectly increase Adcy5 activity by promoting dopamine release. These drugs have been shown to improve ADHD symptoms in many patients.

Can mutations in Adcy5 lead to disease? 11/02/2019

Yes, mutations in Adcy5 have been associated with several different diseases, including Parkinson's disease, ADHD, and epilepsy. These mutations can disrupt the normal activity of the protein, leading to alterations in cellular signaling and function.

How can Adcy5 be used in drug discovery? 05/13/2019

Adcy5 protein and its signaling pathway are potential targets for the development of novel drugs. Drug discovery efforts can aim to either directly or indirectly modulate Adcy5 activity or regulate its downstream signaling pathways. High-throughput screening, virtual screening, and molecular dynamics simulations can be used to identify potential drug candidates.

Are there any side effects associated with targeting Adcy5 with drugs? 01/09/2019

As with any drug, there is always the potential for side effects. However, because Adcy5 is expressed in many different tissues and involved in many different biological processes, any drug targeting Adcy5 would need to be designed specifically to minimize off-target effects.

In what diseases or conditions is Adcy5 involved? 09/07/2018

Adcy5 is involved in a variety of diseases and conditions, including Parkinson's disease, attention deficit hyperactivity disorder (ADHD), epilepsy, type 2 diabetes, and various forms of cancer.

Is Adcy5 protein essential for normal physiological function? 05/29/2018

Yes, Adcy5 is essential for normal physiological function, as it plays a critical role in regulating cyclic AMP (cAMP) levels within cells. cAMP is a critical secondary messenger that is involved in numerous signaling pathways within the cell, including those involved in neurotransmission, metabolism, and hormone signaling.

Can Adcy5 protein be used as a therapeutic target for Parkinson's disease? 05/20/2018

Yes, Adcy5 protein has been implicated in the development and progression of Parkinson's disease. It is involved in dopamine signaling, which is disrupted in Parkinson's disease. Targeting Adcy5, either directly or indirectly, may improve dopamine signaling and alleviate some of the symptoms of Parkinson's disease.

Are there any current therapies that target Adcy5? 11/17/2017

There are currently no therapies that specifically target Adcy5, although several drugs that indirectly modulate its activity have been developed. These include dopamine agonists for Parkinson's disease and stimulant medications for ADHD, which both indirectly target Adcy5 activity via dopamine signaling.

What is the role of Adcy5 in ADHD? 07/31/2017

Adcy5 has been linked to ADHD, although the specific mechanism is not yet fully understood. Studies suggest that genetic variations in Adcy5 may be associated with an increased risk of ADHD.

Can Adcy5 be used as a biomarker for certain diseases? 05/25/2017

Adcy5 gene mutations have been associated with several diseases, including Parkinson's disease, ADHD, and epilepsy. Therefore, Adcy5 may be used as a biomarker for those diseases. However, more research is needed to determine the extent to which Adcy5 can be used as a reliable biomarker.

Is there a role for Adcy5 in cancer development? 01/14/2016

Adcy5 has been implicated in the development and progression of several types of cancer, including lung cancer, liver cancer, and prostate cancer. It is involved in the regulation of cell growth, proliferation, and survival. Targeting Adcy5 and its downstream pathways may provide new opportunities for cancer therapy and improve patient outcomes.

Can Adcy5 be targeted with drugs for Parkinson's disease? 09/17/2015

Yes, Adcy5 is a potential target for drug development in Parkinson's disease. Inhibition of Adcy5 has been shown to reduce the aggregation of alpha-synuclein, which is a hallmark of Parkinson's disease.

Is Adcy5 involved in neuronal signaling? 07/18/2015

Yes, Adcy5 plays an important role in neuronal signaling by regulating the production of cyclic AMP (cAMP). cAMP is an important secondary messenger that is involved in many different signaling pathways within the cell, including those involved in neurotransmission.

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