ADCY7

  • Official Full Name

    adenylate cyclase 7

  • Overview

    This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.
  • Synonyms

    ADCY7; adenylate cyclase 7; adenylate cyclase type 7; AC7; KIAA0037; adenylyl cyclase 7; ATP pyrophosphate-lyase 7; adenylate cyclase type VII; FLJ36387;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADCY7-476H Recombinant Human ADCY7 Mammalian Cell His
Human ADCY7-3180H Recombinant Human ADCY7, His-tagged E.Coli or Yeast His 1080
Human ADCY7-331H Recombinant Human ADCY7 Protein, GST-tagged Wheat Germ GST
Human ADCY7-6932H Recombinant Human ADCY7 protein, His & T7-tagged E.coli His/T7 Phe806~Gly1052 (Accession # P51828)
Human ADCY7-0481H Recombinant Human ADCY7 Protein (Phe806-Gly1052), N-His-tagged E.coli N-His Phe806-Gly1052
Human ADCY7-2430H-B Recombinant Human ADCY7 Protein Pre-coupled Magnetic Beads HEK293
Human ADCY7-2430H Recombinant Human ADCY7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Adcy7-6933M Recombinant Mouse Adcy7 protein, His & T7-tagged E.coli His/T7 Leu309~Glu491 (Accession # P51829)
Mouse Adcy7-3179M Recombinant Mouse Adcy7, His-tagged E.Coli or Yeast His 1099
Zebrafish ADCY7-7608Z Recombinant Zebrafish ADCY7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • ADCY7 Related Signal Pathway

ADCY7 involved in several pathways and played different roles in them. We selected most pathways ADCY7 participated on our site, such as Activation of GABAB receptors, Adenylate cyclase activating pathway, Adenylate cyclase inhibitory pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADCY7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of GABAB receptorsGNGT2B;ADCY3;KCNJ10;KCNJ4;ADCY1;KCNJ15;KCNJ2;ADCY7;KCNJ12
Adenylate cyclase activating pathwayADCY6;ADCY8;ADCY3;ADCY7;ADCY9;ADCY1
Adenylate cyclase inhibitory pathwayADCY3;ADCY7;ADCY6;ADCY8;ADCY1;ADCY9
Adrenergic signaling in cardiomyocytesPPP1CBL;GNAQ;CREB3L4;TNNI3;MAPK1;TPMA;PIK3R5;CACNA2D3;CAMK2G1
Aldosterone synthesis and secretionHSD3B5;ADCY1;ATF2;CREB3L4;DAGLB;ADCY7;ITPR3;PRKD1;LIPE
Aquaporin-mediated transportGNB5B;GNB5;ADCY8;MIPB;AQP11;AQP10B;ADCY1;ADCY3;AQP10
Bile secretionSLC51A;ATP1A4;Slc4a2;SLC22A7;Abcb1b;ABCB1;FXYD2;ATP1A3;ADCY7
Ca-dependent eventsPRKAR1AA;ADCY7;ADCY9;ADRBK1

ADCY7 has several biochemical functions, for example, ATP binding, adenylate cyclase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADCY7 itself. We selected most functions ADCY7 had, and list some proteins which have the same functions with ADCY7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPANK2;CHD4;NME4;SGK196;MAPK15;SRPK1A;FLJ11011L;AARSD1;PRKCBB
adenylate cyclase activityADCY2B;ADCY8;ADCY1B;ADCY1;GNAS;ADCY3;Adcy4;ADCY6;ADCY7
metal ion bindingESRRGA;KLF16;MLL5;ADAMTS7;NCS1B;ITGA2B;ZBTB1;ZBTB43;POGZ

ADCY7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADCY7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADCY7.

PLSCR1; XRCC6; BUD31

Research Area

Related articles

Patocka, N; Sharma, N; et al. Serotonin Signaling in Schistosoma mansoni: A Serotonin-Activated G Protein-Coupled Receptor Controls Parasite Movement. PLOS PATHOGENS 10:-(2014).
Knospe, M; Muller, CE; et al. The rat adenine receptor: pharmacological characterization and mutagenesis studies to investigate its putative ligand binding site. PURINERGIC SIGNALLING 9:367-381(2013).
  • Q&As
  • Reviews

Q&As (15)

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What role does ADCY7 play in the immune system? 08/25/2022

ADCY7 is known to play a critical role in the immune system by regulating the production of anti-inflammatory cytokines and other immune molecules. Studies have shown that ADCY7-deficient mice have impaired T-cell responses and are more susceptible to infections, suggesting that ADCY7 is important for maintaining a healthy immune system.

What are some challenges associated with developing drugs that target ADCY7? 04/03/2022

One of the challenges associated with developing drugs that target ADCY7 is that it is a relatively complex protein with multiple domains and regulatory mechanisms that can affect its activity. Additionally, there is the potential for off-target effects and unintended consequences of modulating ADCY7 activity. Furthermore, it can be difficult to target ADCY7 specifically in certain cells or tissues without affecting other cells or tissues.

How can ADCY7 protein be used in cancer treatment? 01/16/2022

ADCY7 is being explored as a potential target in cancer treatment due to its role in regulating immune responses and inflammation. Modulating ADCY7 activity may help to enhance antitumor immune responses and improve the efficacy of current cancer treatments.

Is there potential for ADCY7-based therapies to be used in combination with other treatments? 08/07/2021

Yes, there is potential for ADCY7-based therapies to be used in combination with other treatments. For example, ADCY7 activators may be used in combination with chemotherapy or radiation therapy to enhance their anticancer effects. Additionally, ADCY7 inhibitors may be used in combination with immunotherapy to enhance T-cell responses in cancer patients.

Is there a link between ADCY7 and diabetes? 07/03/2021

There is evidence to suggest that ADCY7 may play a role in the development of type 2 diabetes. Studies have shown that ADCY7-deficient mice have impaired insulin secretion and glucose homeostasis. Additionally, some genetic variants of ADCY7 have been linked to an increased risk of developing type 2 diabetes in humans.

Are there any ongoing clinical trials involving drugs that target ADCY7? 05/19/2020

To our knowledge, there are currently no ongoing or planned clinical trials specifically targeting ADCY7. However, there are several clinical trials ongoing or planned for drugs that indirectly modulate cAMP signaling pathways for the treatment of various diseases and conditions, including cancer and cardiovascular disease. Some of these drugs may have an effect on ADCY7 activity.

How can researchers better understand the role of ADCY7 in disease? 01/27/2020

Researchers can use a variety of techniques to better understand the role of ADCY7 in disease. These include genetic manipulation of ADCY7 expression or activity in animal models, analysis of human genetic variants associated with disease, and bioinformatics analysis of ADCY7 signaling pathways in disease-related tissues. Additionally, the use of high-throughput screening methods to identify compounds that selectively modulate ADCY7 activity can help to identify potential therapeutic targets.

Are there any drugs currently available that target ADCY7? 01/18/2020

At present, there are no drugs specifically targeting ADCY7 that are approved for clinical use. However, there are several compounds that indirectly modulate cAMP signaling pathways, which are downstream of ADCY7 activity. For example, forskolin is a naturally occurring compound that activates all known types of ADCY, including ADCY7, leading to increased cAMP production.

Can ADCY7 protein be used as a diagnostic tool? 10/23/2018

ADCY7 protein is not typically used as a direct diagnostic tool. However, measuring ADCY7 expression levels or genetic variants associated with ADCY7 may be useful in predicting disease outcomes and identifying patients who may benefit from certain treatments.

Can ADCY7 protein be used to treat diabetes? 07/27/2018

ADCY7 is being studied as a potential therapeutic target in diabetes due to its role in regulating insulin secretion and glucose homeostasis. Activating or inhibiting ADCY7 may help to improve insulin sensitivity and glycemic control in diabetic patients.

Is it possible to supplement ADCY7 protein for therapeutic purposes? 01/24/2018

It is currently not possible to supplement ADCY7 protein for therapeutic purposes. However, the development of ADCY7 agonists or inhibitors may help to modulate ADCY7 activity for therapeutic benefit.

Are there any drugs that target ADCY7 protein? 03/19/2017

There are currently no drugs that specifically target ADCY7 protein. However, compounds that modulate ADCY7 activity are being developed and tested for their therapeutic potential.

Can ADCY7 be used to predict patient outcomes in certain diseases? 10/15/2016

There is some evidence to suggest that ADCY7 expression levels may be predictive of patient outcomes in certain diseases. For example, higher levels of ADCY7 have been associated with better outcomes in patients with breast cancer and lower levels of ADCY7 have been associated with worse outcomes in patients with heart failure.

How can ADCY7 be targeted specifically in certain cells or tissues? 09/06/2016

There are several strategies for targeting ADCY7 specifically in certain cells or tissues. One approach is to use cell-specific promoters to drive expression of an ADCY7 inhibitor or activator. Another approach is to use targeted gene editing techniques, such as CRISPR-Cas9, to specifically modify the ADCY7 gene in certain cells or tissues. Moreover, targeted drug delivery systems, such as nanoparticles or liposomes, can be used to specifically deliver drugs or inhibitors to certain cells or tissues.

What are some potential therapeutic applications of the ADCY7 protein? 02/10/2015

The ADCY7 protein has potential therapeutic applications in the treatment of a wide variety of diseases and conditions, including neurodegenerative disorders, cancer, cardiovascular disease, and metabolic disorders. As an enzyme that converts ATP to cAMP, it plays a critical role in many cellular signaling pathways and is therefore a key target for therapeutic interventions.

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