ADORA2A

  • Official Full Name

    Adora2a adenosine A2a receptor

  • Synonyms

    ADORA2A; adenosine A2a receptor; adenosine receptor A2a; A2a, Rs; A2aR; A2AAR; AA2AR; MGC118414;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Cavia porcellus (Guinea pig)
  • Equus caballus (Horse)
  • Guinea pig
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • Fc
  • Avi
  • Flag
  • TrxA
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADORA2A-0978H Active Recombinant Human ADORA2A Full Length Transmembrane protein(VLPs) HEK293 Non Met 1 - Ser 412
Human ADORA2A-3958H Active Recombinant Human ADORA2A Full Length Transmembrane protein(Nanodisc) HEK293 Non
Human ADORA2A-3959H Active Recombinant Human ADORA2A Full Length Transmembrane protein(MNP) HEK293 Non
Human ADORA2A-368H Recombinant Human ADORA2A Protein, GST-tagged Wheat Germ GST
Human ADORA2A-135H Recombinant Human ADORA2A Mammalian Cell His
Human ADORA2A-367H Recombinant Human ADORA2A Protein Wheat Germ Non
Human ADORA2A-33HCL Recombinant Human ADORA2A cell lysate Non
Human ADORA2A-87H Recombinant Human ADORA2A Protein, His-tagged E.coli His Tyr290-Ser412
Human ADORA2A-967HF Recombinant Full Length Human ADORA2A Protein In Vitro Cell Free System 412 amino acids
Human ADORA2A-318H Recombinant Human ADORA2A protein, GST-tagged E.coli GST 300-412 aa
Human ADORA2A-1149HFL Recombinant Human ADORA2A protein, His&Flag-tagged HEK293 His&Flag 1-412 aa
Human ADORA2A-2435H Recombinant Human ADORA2A Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Human ADORA2A-0572H Recombinant Human ADORA2A Protein (Arg291-Ser412), N-His-tagged E.coli His Arg291-Ser412
Human ADORA2A-18H Recombinant Human ADORA2A Protein (M4-L208, E219-K315, A54L, T88A, R107A, K122A, N154A, L202A, L235A, V239A, S277A), N-Flag/C-10×His-tagged Insect Cell His&Flag M4-L208, E219-K315, A54L, T88A, R107A, K122A, N154A, L202A, L235A, V239A, S277A
Human ADORA2A-971HF Recombinant Full Length Human ADORA2A Protein, GST-tagged In Vitro Cell Free System GST 412 amino acids
Human ADORA2A-0966H Recombinant Human ADORA2A Protein (P2-L208, S91K, E219-A316), Flag, 10×His tagged Insect Cell His&Flag P2-L208, S91K, E219-A316
Human ADORA2A-0965H Recombinant Human ADORA2A Protein (M4-L208, E219-K315, A54L, T88A, R107A, K122A, N154A, L202A, L235A, V239A, S277A), Flag, 10×His tagged Insect Cell His&Flag M4-L208, E219-K315, A54L, T88A, R107A, K122A, N154A, L202A, L235A, V239A, S277A
Human ADORA2A-19H Recombinant Human ADORA2A Protein (P2-L208, E219-A316, S91K), N-Flag/C-10×His-tagged Insect Cell His&Flag P2-L208, E219-A316, S91K
Human ADORA2A-2435H-B Recombinant Human ADORA2A Protein Pre-coupled Magnetic Beads HEK293
Human ADORA2A-21H Recombinant Human ADORA2A Protein (S6-A316, N154A), N-10×His-TEV-TrxA-tagged Insect Cell His&TrxA S6-A316, N154A
Human ADORA2A-0964H Recombinant Human ADORA2A Protein (S6-A316, N154A), 10×His tagged Insect Cell His S6-A316, N154A
Mouse ADORA2A-1371M Recombinant Mouse ADORA2A Protein Mammalian Cell His
Mouse ADORA2A-356M-B Recombinant Mouse ADORA2A Protein Pre-coupled Magnetic Beads HEK293
Mouse ADORA2A-356M Recombinant Mouse ADORA2A Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat ADORA2A-533R Recombinant Rat ADORA2A Protein Mammalian Cell His
Rat ADORA2A-189R Recombinant Rat ADORA2A Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Rat ADORA2A-189R-B Recombinant Rat ADORA2A Protein Pre-coupled Magnetic Beads HEK293
Canis lupus familiaris (Dog) (Canis familiaris) RFL-28450CF Recombinant Full Length Dog Adenosine Receptor A2A(Adora2A) Protein, His-Tagged E.coli expression system His Full Length (1-412)
Cavia porcellus (Guinea pig) RFL-28426CF Recombinant Full Length Guinea Pig Adenosine Receptor A2A(Adora2A) Protein, His-Tagged E.coli expression system His Full Length (1-409)
Equus caballus (Horse) RFL10285EF Recombinant Full Length Horse Adenosine Receptor A2A(Adora2A) Protein, His-Tagged E.coli expression system His Full Length (1-412)
Guinea pig Adora2a-3162C Recombinant Cavia porcellus (Guinea pig) Adora2a, His-tagged E.Coli or Yeast His 409
Mus musculus (Mouse) RFL27954MF Recombinant Full Length Mouse Adenosine Receptor A2A(Adora2A) Protein, His-Tagged E.coli expression system His Full Length (1-410)
Rattus norvegicus (Rat) RFL-20497RF Recombinant Full Length Rat Adenosine Receptor A2A(Adora2A) Protein, His-Tagged E.coli expression system His Full Length (1-410)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ADORA2A involved in several pathways and played different roles in them. We selected most pathways ADORA2A participated on our site, such as Activation of TRKA receptors, Adenosine P1 receptors, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADORA2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of TRKA receptorsADCYAP1R1;NTF7;ADCYAP1;ADORA2A
Adenosine P1 receptorsADORA2A;ADORA2B;ADORA3;ADORA1
AlcoholismCALM4;CREB3L3;HIST1H4C;GM14478;SLC18A1;HIST2H2BE;DRD1;CALM2;HIST1H4G
Calcium signaling pathwayATP2B4;ADRB1;EDNRA;DRD7;TNNC1A;ITPKA;CCKBR;CALM2B;CALM2A
Class A/1 (Rhodopsin-like receptors)EDN3;PROKR1;NPB;AGTR2;NPS;PYYA;GPR4;ADRB3;TAC3
G alpha (s) signalling eventsVIP2;RXFP2B;GHRH;CRHB;ADCYAP1R1;CRHR2;TAAR1;RLN3;RLN3A
GPCR downstream signalingHCRT;AGTR2;HEBP1;OPN1LW1;ANXA1A;INSL5;CNR1;NPB;EDNRA
GPCR ligand bindingGRP;CASR;GPR77;FPR-RS6;RHOL;PTHRP2;INSL5;ADORA1;FFAR3

ADORA2A has several biochemical functions, for example, G-protein coupled adenosine receptor activity, alpha-actinin binding, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADORA2A itself. We selected most functions ADORA2A had, and list some proteins which have the same functions with ADORA2A. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled adenosine receptor activityADORA3;ADORA2AA;P2RY12;ADORA2AB;ADORA2B;ADORA1;ADORA2A
alpha-actinin bindingKCNN2;RARA;MAGI1;KCNA5;LRRC10;ALMS1;PKD2L1;ADORA2A;DAG1
enzyme bindingTBP;KDM1A;YWHAE;HSPA6;APBA3;NOTCH1;NKX2-1;SLC18A1;KAT8
identical protein bindingSERPINA1A;CPT1A;TRIM23;CLDND;RUNX1T1;TRADD;BAG2;S100A2;BLOC1S6
protein bindingC7orf49;IL23;CHUK;SURF1;VMP1;SUDS3;MAL2;TECPR1;CXXC11
protein heterodimerization activityDefa-rs7;HIST1H2BA;TCF4;ADIPOR1;CUL3;H2AFY;TPD52L1;OSTA;HMG20A
type 5 metabotropic glutamate receptor bindingHOMER1;ADORA2A;DNM3

ADORA2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADORA2A here. Most of them are supplied by our site. Hope this information will be useful for your research of ADORA2A.

CYTH2; NECAB2; USP4

  • Reviews
  • Q&As

Customer Reviews (5)

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Reviews
05/20/2020

    The manufacturer has gone above and beyond in providing detailed protocols and troubleshooting guides, which have been invaluable in optimizing my experiments.

    08/20/2019

      the manufacturer's technical support is exemplary and can effectively address any concerns or issues that may arise during the course of my research.

      05/11/2017

        Based on my analysis, the ADORA2A protein is of exceptional quality and will cater to the experimental requirements.

        08/05/2016

          I appreciate the level of support being offered and the willingness of the manufacturer to promptly address any queries or concerns.

          05/22/2016

            I am confident that I made the right choice in selecting this product and manufacturer, and I am excited to continue using it for my research.

            Q&As (13)

            Ask a question
            How is ADORA2A involved in the regulation of the cardiovascular system? 06/21/2022

            ADORA2A is involved in the regulation of the cardiovascular system by mediating the effects of adenosine, which is released from damaged cells in response to tissue injury or hypoxia. ADORA2A activation can lead to vasodilation, which increases blood flow and oxygen delivery to the affected tissues. Additionally, ADORA2A activation can reduce heart rate and blood pressure, which can be beneficial in certain cardiovascular conditions.

            What are the potential therapeutic applications of ADORA2A agonists and antagonists? 09/27/2021

            ADORA2A agonists and antagonists have been investigated as potential therapeutics for a variety of conditions. For example, ADORA2A agonists have been tested for their potential to reduce inflammation in diseases like asthma and chronic obstructive pulmonary disease (COPD), as well as for their potential to improve cognitive function in Alzheimer's disease and Parkinson's disease. ADORA2A antagonists have been investigated as potential treatments for depression, anxiety, and addiction, as they may increase the activity of dopamine neurons in the brain.

            What are some potential therapeutic applications of ADORA2A agonists and antagonists? 08/28/2021

            ADORA2A agonists and antagonists have a range of potential therapeutic applications. ADORA2A agonists have been investigated as potential treatments for various conditions including inflammation, neurodegenerative disorders, and cardiac ischemia/reperfusion injury. ADORA2A antagonists have also shown potential as therapeutic agents for conditions such as asthma, chronic obstructive pulmonary disease (COPD), and Parkinson's disease. In asthma and COPD, ADORA2A antagonists can block the bronchospasm-inducing effects of adenosine, improving lung function. In Parkinson's disease, ADORA2A antagonists have been shown to improve motor function and reduce levodopa-induced dyskinesia. Additionally, ADORA2A antagonists have been investigated as potential treatments for cognitive impairment and depression.

            How does ADORA2A affect the immune system? 06/04/2021

            ADORA2A has been shown to exert immunosuppressive effects on the immune system. Adenosine, the ligand for ADORA2A, is produced by various cells in response to tissue damage or inflammation, and acts to suppress immune cell activation, cytokine production and T cell proliferation. This helps to limit the inflammatory response and prevent autoimmune reactions. In addition, ADORA2A expression has been found on a wide range of immune cells, including T cells, B cells, dendritic cells and macrophages, indicating that ADORA2A signaling is involved in the regulation of various aspects of immune function.

            Are there any genetic mutations associated with ADORA2A that have clinical significance? 04/20/2021

            Yes, there are several genetic mutations associated with ADORA2A that have been linked to various diseases. For example, a genetic variant in the ADORA2A gene has been found to be associated with an increased risk of Parkinson's disease. Another variant has been linked to an increased risk of developing schizophrenia. These findings suggest that genetic variations in ADORA2A may impact the risk of developing certain neurological and psychiatric disorders.

            How is ADORA2A involved in inflammation? 06/04/2020

            ADORA2A has anti-inflammatory effects and can modulate the immune response to inflammation. Adenosine, the ligand for ADORA2A, is produced during tissue damage and inflammation and acts to suppress immune cell activation, cytokine production and T cell proliferation. This helps to limit the inflammatory response and prevent autoimmune reactions. Additionally, ADORA2A expression has been found on a wide range of immune cells, including T cells, B cells, dendritic cells and macrophages, indicating that ADORA2A signaling is involved in the regulation of various aspects of immune function. ADORA2A agonists have been investigated as potential treatments for inflammatory conditions such as rheumatoid arthritis and Crohn's disease.

            Are there any foods or supplements that can affect ADORA2A activity? 07/29/2019

            Yes, some food and supplements have been shown to affect ADORA2A activity. For example, caffeine and theophylline (found in tea and chocolate) are known ADORA2A antagonists and can block the effects of adenosine in the brain. On the other hand, green tea and chocolate, which contain epigallocatechin gallate (EGCG) and epicatechin, respectively, have been shown to activate ADORA2A and improve cognitive function. Resveratrol, found in red wine and grapes, also activates ADORA2A and has been shown to improve cardiovascular health.

            What methods are used to target ADORA2A in therapy? 06/11/2019

            ADORA2A can be targeted in therapy using various methods, including small molecule agonists or antagonists, monoclonal antibodies, and gene therapy. Small molecule agonists or antagonists can be administered orally or intravenously and can easily penetrate the blood-brain barrier to target ADORA2A in the brain. Monoclonal antibodies can be used to selectively target ADORA2A-expressing cells, while gene therapy can be used to modulate ADORA2A expression in specific tissues.

            Can ADORA2A be targeted in cancer therapy? 06/11/2018

            Yes, ADORA2A has been implicated in the development of cancer and its progression. ADORA2A activation can promote tumor growth and metastasis, while ADORA2A antagonists have been shown to inhibit tumor growth and improve immune response against cancer cells. Therefore, ADORA2A has been investigated as a potential target for cancer therapy, and several ADORA2A antagonists are currently in preclinical and clinical development for various cancers.

            How does ADORA2A affect the cardiovascular system? 10/27/2017

            ADORA2A has been shown to have several cardiovascular effects, including vasodilation, inhibition of smooth muscle cell proliferation, and protection against ischemia/reperfusion injury. ADORA2A expression has been detected in the heart, blood vessels, and endothelial cells, indicating that it is involved in the regulation of cardiovascular function. ADORA2A activation leads to the release of nitric oxide and cGMP, both of which are potent vasodilators and contribute to improved blood flow. Additionally, ADORA2A activation has been shown to reduce myocardial infarct size and improve cardiac function following ischemia/reperfusion injury.

            Are there any potential side effects associated with targeting ADORA2A in therapy? 05/27/2017

            Yes, there are potential side effects associated with targeting ADORA2A in therapy. For example, ADORA2A agonists may cause insomnia, anxiety, and tremors, while ADORA2A antagonists may cause nausea, vomiting, and changes in blood pressure. Additionally, ADORA2A targeting may potentially increase the risk of arrhythmias in patients with underlying cardiac conditions. Therefore, careful consideration of the potential risks and benefits is necessary before using ADORA2A-targeted therapies in patients.

            How is ADORA2A research relevant to drug addiction and substance abuse disorders? 08/09/2016

            ADORA2A targeting has been investigated as a potential treatment for drug addiction and substance use disorders. Preclinical studies have shown that ADORA2A agonists can reduce drug addiction-related behaviors, such as drug-seeking and relapse, by modulating dopamine release in the brain reward system. Additionally, ADORA2A antagonists may reduce the rewarding effects of drugs of abuse and decrease drug-induced hyperactivity. Therefore, ADORA2A targeting may provide a new approach for managing drug addiction and substance use disorders.

            Are there any ADORA2A-related clinical trials currently ongoing? 07/11/2016

            Yes, there are several ongoing clinical trials investigating ADORA2A-targeted therapies for various conditions. For example, ADORA2A antagonists are being tested in clinical trials for the treatment of depression, anxiety disorders, and cocaine use disorder. An ADORA2A agonist is also being evaluated in a clinical trial for the treatment of asthma. Additionally, ADORA2A-targeted therapies are being investigated in clinical trials for cancer and cardiovascular diseases.

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