AHSA1
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Official Full Name
AHA1, activator of heat shock 90kDa protein ATPase homolog 1
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Overview
Activator of 90 kDa heat shock protein ATPase homolog 1 is an enzyme that in humans is encoded by the AHSA1 gene. -
Synonyms
AHSA1; AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); C14orf3, chromosome 14 open reading frame 3; activator of 90 kDa heat shock protein ATPase homolog 1; p38; AHA1; C14orf3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
AHSA1 involved in several pathways and played different roles in them. We selected most pathways AHSA1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AHSA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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AHSA1 has several biochemical functions, for example, ATPase activator activity, chaperone binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AHSA1 itself. We selected most functions AHSA1 had, and list some proteins which have the same functions with AHSA1. You can find most of the proteins on our site.
Function | Related Protein |
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ATPase activator activity | DNAJC24;DNAJB1;AHSA2;RAB4A;DNAJB6;MYBPC3;DNAJC15;DNAJC10;ATP1B2 |
chaperone binding | UBL4A;DNAJB1;TBCC;AHSA1L;BIRC5;DNAJB7;HLA-B;DNAJA2L;ATP1A2 |
protein binding | MEF2D;SR140;CD70;EOMESA;FLVCR1;TNFAIP8;NOP2;ARAP3;C1QTNF1 |
AHSA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AHSA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AHSA1.
HSP90AB1; HSP90AA1; GCH1; PTP4A3; EEF1D; HLA-B; EIF6; IRF3; C20orf24; NEK6; SCHIP1; FTSJ1; GSTK1
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Q&As (10)
Ask a questionAHSA1 stimulates the ATPase activity of HSP90, enhancing its chaperone function and facilitating the folding, stabilization, and maturation of client proteins.
AHSA1 promotes conformational changes in HSP90 that enhance its ATPase activity, facilitating the release of client proteins at different stages of folding.
AHSA1 assists in proper folding of proteins destined for specific cellular compartments, contributing to their accurate localization.
These techniques can reveal the complex architecture of the AHSA1-HSP90 complex and provide insights into the conformational changes it undergoes during its chaperone cycle.
Western blotting, immunofluorescence microscopy, and proximity ligation assays can be employed to study AHSA1 expression and its colocalization with HSP90 in stressed cells.
Techniques like co-immunoprecipitation, surface plasmon resonance, and X-ray crystallography provide insights into the AHSA1-HSP90 interaction.
Assays like malachite green or colorimetric methods can be used to quantify the release of inorganic phosphate, indicative of ATP hydrolysis, in the presence of AHSA1 and HSP90.
Small molecules that disrupt the AHSA1-HSP90 interaction could be designed to interfere with client protein folding and impact disease-associated pathways.
Client proteins include various kinases, steroid hormone receptors, and transcription factors involved in cell signaling and gene regulation.
AHSA1 can stabilize and facilitate the correct assembly of multi-protein complexes, thereby modulating cellular signaling cascades.
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