Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Human AHSA1 Protein, GST-tagged

Cat.No. : AHSA1-467H
Product Overview : Human AHSA1 full-length ORF ( AAH00321, 1 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
  • Related Products
Description : AHSA1 (Activator Of HSP90 ATPase Activity 1) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA2.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 62.92 kDa
AA Sequence : MAKWGEGDPRWIVEERANATNVNNW HWTERDASNWSTDKLKTLFLAVQVQ NEEGKCEVTEVSKLDGEASINNRKG KLIFFYEWSVKLNWTGTSKSGVQYK GHVEIPNLSGENSVDEVEISVSLAK DEPDTNLVALMKEEGVKLLREAMGI YISTLKTEFTQGMILPTMNGESVDP VGQPALKTEERKAKPAPSKTQARPV GVKIPTCKITLKETFLTSPEELYRV FTTQELVQAFTHAPATLEADRGGKF HMVDGNVSGEFTDLVPEKHIVMKWR FKSWPEGHFATITLTFIDKNGETEL CMEGRGIPAPEEERTRQGWQRYYFE GIKQTFGYGARLF
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) [ Homo sapiens ]
Official Symbol : AHSA1
Synonyms : AHSA1; AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); C14orf3, chromosome 14 open reading frame 3; activator of 90 kDa heat shock protein ATPase homolog 1; p38; AHA1; C14orf3;
Gene ID : 10598
mRNA Refseq : NM_012111
Protein Refseq : NP_036243
MIM : 608466
UniProt ID : O95433

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does AHSA1 regulate the chaperone activity of HSP90? 09/22/2022

AHSA1 stimulates the ATPase activity of HSP90, enhancing its chaperone function and facilitating the folding, stabilization, and maturation of client proteins.

How does AHSA1's activity contribute to the conformational changes of HSP90 during the chaperone cycle? 08/08/2022

AHSA1 promotes conformational changes in HSP90 that enhance its ATPase activity, facilitating the release of client proteins at different stages of folding.

What is the role of AHSA1 in protein trafficking and localization within cells? 07/02/2022

AHSA1 assists in proper folding of proteins destined for specific cellular compartments, contributing to their accurate localization.

How can structural biology techniques, such as cryo-electron microscopy, contribute to understanding AHSA1's mechanism of action? 12/03/2021

These techniques can reveal the complex architecture of the AHSA1-HSP90 complex and provide insights into the conformational changes it undergoes during its chaperone cycle.

In the lab, what methods are used to study the dynamic changes in AHSA1 expression and its interaction with HSP90 under stress? 06/19/2021

Western blotting, immunofluorescence microscopy, and proximity ligation assays can be employed to study AHSA1 expression and its colocalization with HSP90 in stressed cells.

How is the interaction between AHSA1 and HSP90 characterized at the molecular level? 08/31/2020

Techniques like co-immunoprecipitation, surface plasmon resonance, and X-ray crystallography provide insights into the AHSA1-HSP90 interaction.

What biochemical assays are used to measure the ATPase-stimulating activity of AHSA1 on HSP90? 02/23/2020

Assays like malachite green or colorimetric methods can be used to quantify the release of inorganic phosphate, indicative of ATP hydrolysis, in the presence of AHSA1 and HSP90.

How can the AHSA1-HSP90 complex be targeted for therapeutic interventions? 06/04/2019

Small molecules that disrupt the AHSA1-HSP90 interaction could be designed to interfere with client protein folding and impact disease-associated pathways.

What are some examples of client proteins that depend on the AHSA1-HSP90 complex for proper folding and function? 03/15/2019

Client proteins include various kinases, steroid hormone receptors, and transcription factors involved in cell signaling and gene regulation.

How does AHSA1 influence the assembly of multi-protein complexes involved in cellular signaling pathways? 10/12/2018

AHSA1 can stabilize and facilitate the correct assembly of multi-protein complexes, thereby modulating cellular signaling cascades.

Customer Reviews (5)

Write a review
Reviews
01/17/2022

    Top-quality item well worth the price. Supportive customer service.

    12/23/2021

      Affordable yet exceptional quality. Customer service made the process easy.

      04/05/2020

        Quality met the price point, and the customer service was exceptional.

        06/09/2019

          Received superb customer service and a premium product at a fair price.

          09/28/2018

            Product quality justified the cost, and the customer service was excellent.

            Ask a Question for All AHSA1 Products

            Required fields are marked with *

            My Review for All AHSA1 Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends