Recombinant Human AHSA1 Protein, GST-tagged
Cat.No. : | AHSA1-467H |
Product Overview : | Human AHSA1 full-length ORF ( AAH00321, 1 a.a. - 338 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | AHSA1 (Activator Of HSP90 ATPase Activity 1) is a Protein Coding gene. Diseases associated with AHSA1 include Stomatitis. Among its related pathways are Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). GO annotations related to this gene include chaperone binding and ATPase activator activity. An important paralog of this gene is AHSA2. |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 62.92 kDa |
AA Sequence : | MAKWGEGDPRWIVEERANATNVNNW HWTERDASNWSTDKLKTLFLAVQVQ NEEGKCEVTEVSKLDGEASINNRKG KLIFFYEWSVKLNWTGTSKSGVQYK GHVEIPNLSGENSVDEVEISVSLAK DEPDTNLVALMKEEGVKLLREAMGI YISTLKTEFTQGMILPTMNGESVDP VGQPALKTEERKAKPAPSKTQARPV GVKIPTCKITLKETFLTSPEELYRV FTTQELVQAFTHAPATLEADRGGKF HMVDGNVSGEFTDLVPEKHIVMKWR FKSWPEGHFATITLTFIDKNGETEL CMEGRGIPAPEEERTRQGWQRYYFE GIKQTFGYGARLF |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) [ Homo sapiens ] |
Official Symbol : | AHSA1 |
Synonyms : | AHSA1; AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast); C14orf3, chromosome 14 open reading frame 3; activator of 90 kDa heat shock protein ATPase homolog 1; p38; AHA1; C14orf3; |
Gene ID : | 10598 |
mRNA Refseq : | NM_012111 |
Protein Refseq : | NP_036243 |
MIM : | 608466 |
UniProt ID : | O95433 |
Products Types
◆ Recombinant Protein | ||
Ahsa1-1568M | Recombinant Mouse Ahsa1 Protein, Myc/DDK-tagged | +Inquiry |
AHSA1-105R | Recombinant Rhesus Macaque AHSA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AHSA1-322H | Recombinant Human AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast) | +Inquiry |
AHSA1-9499H | Recombinant Human AHSA1, GST-tagged | +Inquiry |
AHSA1-277R | Recombinant Rhesus monkey AHSA1 Protein, His-tagged | +Inquiry |
◆ Lysates | ||
AHSA1-8961HCL | Recombinant Human AHSA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAHSA1 stimulates the ATPase activity of HSP90, enhancing its chaperone function and facilitating the folding, stabilization, and maturation of client proteins.
AHSA1 promotes conformational changes in HSP90 that enhance its ATPase activity, facilitating the release of client proteins at different stages of folding.
AHSA1 assists in proper folding of proteins destined for specific cellular compartments, contributing to their accurate localization.
These techniques can reveal the complex architecture of the AHSA1-HSP90 complex and provide insights into the conformational changes it undergoes during its chaperone cycle.
Western blotting, immunofluorescence microscopy, and proximity ligation assays can be employed to study AHSA1 expression and its colocalization with HSP90 in stressed cells.
Techniques like co-immunoprecipitation, surface plasmon resonance, and X-ray crystallography provide insights into the AHSA1-HSP90 interaction.
Assays like malachite green or colorimetric methods can be used to quantify the release of inorganic phosphate, indicative of ATP hydrolysis, in the presence of AHSA1 and HSP90.
Small molecules that disrupt the AHSA1-HSP90 interaction could be designed to interfere with client protein folding and impact disease-associated pathways.
Client proteins include various kinases, steroid hormone receptors, and transcription factors involved in cell signaling and gene regulation.
AHSA1 can stabilize and facilitate the correct assembly of multi-protein complexes, thereby modulating cellular signaling cascades.
Customer Reviews (5)
Write a reviewTop-quality item well worth the price. Supportive customer service.
Affordable yet exceptional quality. Customer service made the process easy.
Quality met the price point, and the customer service was exceptional.
Received superb customer service and a premium product at a fair price.
Product quality justified the cost, and the customer service was excellent.
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