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Akr1c6

  • Official Full Name

    aldo-keto reductase family 1, member C6

Species Cat.# Product name Source (Host) Tag Protein Length Price
Mouse AKR1C6-1502M Recombinant Mouse AKR1C6 Protein Mammalian Cell His
Mouse AKR1C6-439M-B Recombinant Mouse AKR1C6 Protein Pre-coupled Magnetic Beads HEK293
Mouse AKR1C6-439M Recombinant Mouse AKR1C6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

Akr1c6 involved in several pathways and played different roles in them. We selected most pathways Akr1c6 participated on our site, such as Arachidonic acid metabolism, Bile acid and bile salt metabolism, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with Akr1c6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Arachidonic acid metabolismGGT5A;CYP4F14;PLA2G2E;CBR1L;PTGS1;FAM213B;ALOX8;CYP2C54;DPEP1
Bile acid and bile salt metabolismAKR1C4;AKR1C2;SLC27A2A;CYP27A1;SLC27A2;CYP8B2;SLC27A5;ACOT8;SLCO1B1
MetabolismCTHL;CTH;INSIG1;MED16;GLYATL1;FA2H;ALOX5B.2;AKR1C6;ARL2BP
Metabolism of lipids and lipoproteinsGLTPD1;ACOT7;PPM1LB;PPARGC1B;PPM1LA;ACOT8;APOEB;FABP11A;FAAH2A
RA biosynthesis pathwayDHRS9;CRABP1B;RDH14A;RDH13;AKR1C21;SDR16C5;RDH14B;DHRS3A;CRABP1A
Retinoid metabolism and transportAPOC2;BCO2;RBP2A;APOA4A;APOM;AKR1C6;CLPS;AKR1C21;RBP4
Signal TransductionFAM13B;BBS13;CDC42EP2;ADH8B;PTGDR2;QRFP;OPN1LW2;LPAR2B;ARHGAP4A
Signaling by Retinoic AcidCRABP1B;PDK3B;RDH13;PDK3;PDK2B;DHRS3A;DHRS4;CRABP1A;DHRS9

Akr1c6 has several biochemical functions, for example, (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity, (R)-2-hydroxyglutarate dehydrogenase activity, (R)-2-hydroxyisocaproate dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Akr1c6 itself. We selected most functions Akr1c6 had, and list some proteins which have the same functions with Akr1c6. You can find most of the proteins on our site.

Function Related Protein
(R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activityHSD3B6;SDR42E1;SDR16C6;H2-KE6;AKR1C6;AKR1C21;HSD11B1LA;HSD3B5
(R)-2-hydroxyglutarate dehydrogenase activitySDR16C6;HSD11B1LA;AKR1C21;HSD3B6;H2-KE6;HSD3B5;D2HGDH;AKR1C6;SDR42E1
(R)-2-hydroxyisocaproate dehydrogenase activitySDR16C6;AKR1C21;HSD3B5;H2-KE6;AKR1C6;SDR42E1;HSD3B6;HSD11B1LA
17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activityAKR1C6;HSD17B2
2-hydroxytetrahydrofuran dehydrogenase activityHSD3B6;H2-KE6;HSD11B1LA;AKR1C6;SDR16C6;HSD3B5;SDR42E1;AKR1C21
3-hydroxymenthone dehydrogenase activityHSD11B1LA;AKR1C21;HSD3B5;AKR1C6;SDR42E1;SDR16C6;HSD3B6;H2-KE6
3-ketoglucose-reductase activitySDR42E1;HSD3B5;H2-KE6;HSD3B6;SDR16C6;AKR1C21;HSD11B1LA;AKR1C6
5-exo-hydroxycamphor dehydrogenase activityHSD11B1LA;AKR1C6;AKR1C21;SDR16C6;HSD3B6;H2-KE6;HSD3B5;SDR42E1
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activitySDR42E1;HSD3B6;HSD3B5;H2-KE6;AKR1C6;SDR16C6;AKR1C21;HSD11B1LA
D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activityAKR1C21;HSD3B5;SDR42E1;SDR16C6;H2-KE6;HSD11B1LA;HSD3B6;AKR1C6
D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activityAKR1C21;SDR42E1;HSD11B1LA;HSD3B6;HSD3B5;H2-KE6;SDR16C6;AKR1C6
D-xylose:NADP reductase activityHSD11B1LA;AKR1C6;H2-KE6;AKR1C21;HSD3B5;SDR16C6;HSD3B6;SDR42E1
L-arabinose 1-dehydrogenase (NADP+) activityHSD11B1LA;AKR1C21;HSD3B5;AKR1C6;HSD3B6;SDR42E1;SDR16C6;H2-KE6
L-arabinose:NADP reductase activityAKR1C21;H2-KE6;SDR42E1;HSD3B6;AKR1C6;HSD11B1LA;SDR16C6;HSD3B5
L-xylulose reductase (NAD+) activityHSD11B1LA;AKR1C21;H2-KE6;HSD3B5;HSD3B6;SDR16C6;AKR1C6;SDR42E1
acetoin dehydrogenase activitySDR42E1;HSD11B1LA;HSD3B6;AKR1C6;SDR16C6;H2-KE6;AKR1C21;HSD3B5
aldo-keto reductase (NADP) activityCYB5A;HSD3B5;AKR1C4;MIOX;SDR42E1;SPR;AKR1C6;AKR1C3;KCNAB1
androsterone dehydrogenase activityAKR1C21;AKR1C4;AKR1C6;AKR1C3
dihydrotestosterone 17-beta-dehydrogenase activitySDR16C6;SDR42E1;HSD3B6;H2-KE6;AKR1C6;HSD3B5;AKR1C21;HSD11B1LA;AKR1C3
epoxide dehydrogenase activityAKR1C6;HSD3B5;SDR42E1;HSD3B6;H2-KE6;AKR1C21;HSD11B1LA;SDR16C6
estradiol 17-beta-dehydrogenase activityAKR1C6;HSD17B8;HSD17B7;HSD17B2;HSD17B6;AKR1B15;HSD17B12B;RDH8B;HSD17B12
gluconate dehydrogenase activityHSD3B5;H2-KE6;HSD3B6;SDR42E1;AKR1C21;SDR16C6;AKR1C6;HSD11B1LA
isocitrate dehydrogenase activitySDR16C6;SDR42E1;HSD11B1LA;HSD3B6;HSD3B5;H2-KE6;AKR1C21;AKR1C6
mevaldate reductase activityAKR1C6;H2-KE6;SDR42E1;AKR1C21;SDR16C6;HSD3B5;HSD11B1LA;HSD3B6
oxidoreductase activityCREG1;GULO;TXNDC17;CYP4V8;AKR1A1A;HSD17B6;RDH13;CYP2F2;RDH12L
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorDHRS4;DCXR;AKR1C6;AKR1C3;CBR1;AKR1C4;NDUFS7;AKR1C2;AKR1C21
phenylcoumaran benzylic ether reductase activityAKR1C6;H2-KE6;SDR16C6;HSD3B6;HSD11B1LA;HSD3B5;AKR1C21;SDR42E1
retinal dehydrogenase activityAKR1C3;ALDH1A3;AKR1C6;ALDH8A1;Aldh1a7;AKR1B10;AKR1B8;ALDH1A1;AKR1C4
steroid dehydrogenase activityHSD3B5;SDR42E1;HSD17B11;HSD11B1LA;SDR16C6;HSD3B6;AKR1C6;AKR1C21;H2-KE6
steroid dehydrogenase activity, acting on the CH-CH group of donorsHSD3B5;H2-KE6;HSD11B1LA;SDR16C6;SDR42E1;HSD3B6;AKR1C21;AKR1C6
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorSDR42E1;HSD3B6;AKR1C21;H2-KE6;AKR1C6;HSD11B1LA;SDR16C6;HSD3B5
testosterone 17-beta-dehydrogenase (NADP+) activityHSD17B3;AKR1C6;AKR1C3;HSD17B14
very long-chain-3-hydroxyacyl-CoA dehydrogenase activityAKR1C6;HSD11B1LA;SDR16C6;HSD3B6;SDR42E1;HSD3B5;H2-KE6;AKR1C21

Akr1c6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Akr1c6 here. Most of them are supplied by our site. Hope this information will be useful for your research of Akr1c6.

Ywhae; Pgls; Hsd3b7

  • Q&As
  • Reviews

Q&As (12)

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What are the substrates of AKR1C6 protein? 03/25/2023

AKR1C6 has broad substrate specificity and can catalyze the reduction of a wide range of carbonyl compounds. Some of its known substrates include steroids, such as testosterone and progesterone, as well as prostaglandins and xenobiotics.

Where is AKR1C6 protein found in the body? 12/31/2022

AKR1C6 protein is primarily found in the liver, although it is also present in other tissues such as the placenta, brain, and kidney. Its expression can vary depending on physiological conditions and developmental stages.

Are there any genetic variations or polymorphisms in the AKR1C6 gene? 03/14/2021

Yes, genetic variations and polymorphisms have been identified in the AKR1C6 gene. Some of these variants may affect the expression or activity of the protein and have been linked to certain diseases or drug responses. Further research is needed to fully understand the implications of these genetic variations.

Is there a connection between AKR1C6 protein and inflammation? 02/07/2021

Yes, AKR1C6 has been associated with inflammation. It can modulate the production of inflammatory mediators, such as prostaglandins, and influence processes involved in inflammation, including immune responses and tissue damage.

How is AKR1C6 protein regulated? 12/22/2020

The expression and activity of AKR1C6 can be regulated at various levels. Transcriptional regulation is one mechanism that controls AKR1C6 expression. The protein can also be subject to post-translational modifications, such as phosphorylation or acetylation, which can affect its enzymatic activity and stability.

Are there any therapeutic applications related to AKR1C6? 06/02/2020

AKR1C6 is being explored as a target for therapeutic interventions. Inhibitors of AKR1C6 could potentially be developed for the treatment of cancers where it is overexpressed. Additionally, modulating its activity may have implications in hormone-related disorders and inflammatory conditions.

Are there any diseases or conditions associated with AKR1C6 protein? 12/16/2018

Alterations in AKR1C6 expression or activity have been implicated in various diseases and conditions. For example, dysregulation of AKR1C6 has been linked to certain types of cancer, including prostate and breast cancer. It has also been associated with disorders of steroid hormone metabolism and inflammation-related pathologies.

Are there any inhibitors or activators of AKR1C6 protein? 02/10/2018

Several compounds have been identified as inhibitors or activators of AKR1C6. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) like flufenamic acid can inhibit AKR1C6 activity. On the other hand, certain natural products like resveratrol have been shown to activate AKR1C6.

Does AKR1C6 play a role in cancer? 08/17/2017

AKR1C6 has been implicated in cancer development and progression. It is often upregulated in certain types of cancer, such as liver, prostate, and breast cancer. Its overexpression may contribute to tumor growth, hormone-related carcinogenesis, and drug resistance.

What are the biological implications of AKR1C6 protein? 11/04/2016

AKR1C6 protein plays a crucial role in the metabolism and detoxification of endogenous and exogenous compounds. It is involved in the biosynthesis and inactivation of steroid hormones, including androgens and estrogens. Additionally, AKR1C6 can modulate inflammatory processes by regulating the levels of prostaglandins.

Can AKR1C6 be used as a biomarker? 07/31/2016

AKR1C6 has been proposed as a potential biomarker in various diseases. Its altered expression or activity may serve as an indicator of certain pathologies, including liver diseases, hormone-related disorders, and certain cancers. However, more research is needed to validate its clinical utility.

Is AKR1C6 protein involved in drug metabolism? 07/29/2016

Yes, AKR1C6 is involved in the metabolism of various drugs and xenobiotics. It can metabolize certain anticancer drugs, such as etoposide and daunorubicin, as well as environmental toxins like polycyclic aromatic hydrocarbons.

Customer Reviews (4)

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Reviews
04/04/2023

    The AKR1C6 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

    05/20/2021

      Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.

      07/04/2020

        The AKR1C6 protein comes highly recommended for its outstanding performance in ELISA assays.

        01/27/2016

          the AKR1C6 protein has proven to be invaluable in protein electron microscopy structure analysis.

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