Recombinant Mouse AKR1C6 Protein

• Cat.No.: AKR1C6-1502M
• Product Overview: Recombinant Mouse AKR1C6 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Mouse
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Akr1c6 aldo-keto reductase family 1, member C6 [ Mus musculus ]
• Official Symbol: AKR1C6
• Gene ID: 83702
• mRNA Refseq: NM_030611.3
• Protein Refseq: NP_085114.1
• UniProt ID: P70694

Reviews

04/04/2023

The AKR1C6 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.

05/20/2021

Its ability to provide accurate and reliable results in this particular application makes it a preferred choice for researchers studying antigen-antibody interactions and immune responses.

07/04/2020

The AKR1C6 protein comes highly recommended for its outstanding performance in ELISA assays.

01/27/2016

the AKR1C6 protein has proven to be invaluable in protein electron microscopy structure analysis.

Q&As

What are the substrates of AKR1C6 protein?

AKR1C6 has broad substrate specificity and can catalyze the reduction of a wide range of carbonyl compounds. Some of its known substrates include steroids, such as testosterone and progesterone, as well as prostaglandins and xenobiotics.

Where is AKR1C6 protein found in the body?

AKR1C6 protein is primarily found in the liver, although it is also present in other tissues such as the placenta, brain, and kidney. Its expression can vary depending on physiological conditions and developmental stages.

Are there any genetic variations or polymorphisms in the AKR1C6 gene?

Yes, genetic variations and polymorphisms have been identified in the AKR1C6 gene. Some of these variants may affect the expression or activity of the protein and have been linked to certain diseases or drug responses. Further research is needed to fully understand the implications of these genetic variations.

Is there a connection between AKR1C6 protein and inflammation?

Yes, AKR1C6 has been associated with inflammation. It can modulate the production of inflammatory mediators, such as prostaglandins, and influence processes involved in inflammation, including immune responses and tissue damage.

How is AKR1C6 protein regulated?

The expression and activity of AKR1C6 can be regulated at various levels. Transcriptional regulation is one mechanism that controls AKR1C6 expression. The protein can also be subject to post-translational modifications, such as phosphorylation or acetylation, which can affect its enzymatic activity and stability.

Are there any therapeutic applications related to AKR1C6?

AKR1C6 is being explored as a target for therapeutic interventions. Inhibitors of AKR1C6 could potentially be developed for the treatment of cancers where it is overexpressed. Additionally, modulating its activity may have implications in hormone-related disorders and inflammatory conditions.

Are there any diseases or conditions associated with AKR1C6 protein?

Alterations in AKR1C6 expression or activity have been implicated in various diseases and conditions. For example, dysregulation of AKR1C6 has been linked to certain types of cancer, including prostate and breast cancer. It has also been associated with disorders of steroid hormone metabolism and inflammation-related pathologies.

Are there any inhibitors or activators of AKR1C6 protein?

Several compounds have been identified as inhibitors or activators of AKR1C6. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) like flufenamic acid can inhibit AKR1C6 activity. On the other hand, certain natural products like resveratrol have been shown to activate AKR1C6.

Does AKR1C6 play a role in cancer?

AKR1C6 has been implicated in cancer development and progression. It is often upregulated in certain types of cancer, such as liver, prostate, and breast cancer. Its overexpression may contribute to tumor growth, hormone-related carcinogenesis, and drug resistance.

What are the biological implications of AKR1C6 protein?

AKR1C6 protein plays a crucial role in the metabolism and detoxification of endogenous and exogenous compounds. It is involved in the biosynthesis and inactivation of steroid hormones, including androgens and estrogens. Additionally, AKR1C6 can modulate inflammatory processes by regulating the levels of prostaglandins.

Can AKR1C6 be used as a biomarker?

AKR1C6 has been proposed as a potential biomarker in various diseases. Its altered expression or activity may serve as an indicator of certain pathologies, including liver diseases, hormone-related disorders, and certain cancers. However, more research is needed to validate its clinical utility.

Is AKR1C6 protein involved in drug metabolism?

Yes, AKR1C6 is involved in the metabolism of various drugs and xenobiotics. It can metabolize certain anticancer drugs, such as etoposide and daunorubicin, as well as environmental toxins like polycyclic aromatic hydrocarbons.