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Official Full Name aldehyde dehydrogenase 3 family, member A1
Background Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
Synonyms ALDH3A1; aldehyde dehydrogenase 3 family, member A1; ALDH3; ALDHIII; aldehyde dehydrogenase, dimeric NADP-preferring; stomach aldehyde dehydrogenase; aldehyde dehydrogenase type III; aldehyde dehydrogenase isozyme 3;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ALDH3A1-1803H Recombinant Human ALDH3A1, His tagged Insect Cell His
    Human ALDH3A1-27038TH Recombinant Human ALDH3A1, His-tagged E.coli His
    Human ALDH3A1-27040TH Recombinant Human ALDH3A1, His-tagged E.coli His
    Human ALDH3A1-2876H Recombinant Human ALDH3A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH3A1-2997H Recombinant Human ALDH3A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ALDH3A1-445H Recombinant Human ALDH3A1 Protein, GST-tagged Wheat Germ GST
    Human ALDH3A1-497H Recombinant Human ALDH3A1 protein, His-tagged E.coli His
    Human ALDH3A1-542HCL Recombinant Human ALDH3A1 cell lysate Insect Cell N/A
    Mouse ALDH3A1-1526M Recombinant Mouse ALDH3A1 Protein Mammalian Cell His
    Mouse Aldh3a1-3263M Recombinant Mouse Aldh3a1, His-tagged E.Coli or Yeast His
    Mouse Aldh3a1-571M Recombinant Mouse Aldh3a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat ALDH3A1-621R Recombinant Rat ALDH3A1 Protein Mammalian Cell His

    aldh3a1 involved in several pathways and played different roles in them. We selected most pathways aldh3a1 participated on our site, such as Glycolysis / Gluconeogenesis, Histidine metabolism, Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with aldh3a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Glycolysis / Gluconeogenesis ALDOCA; ALDH3B1; PDHA1A; ADH7; ACSS2; GPI1; ADH1C; GPIB; G6PC2; HKDC1
    Histidine metabolism FTCD; UROC1; ALDH1B1; CARNS1; MAOB; ALDH2.1; ALDH9A1A.1; ALDH3A2A; ALDH7A1; CNDP2
    Tyrosine metabolism ALDH3B2; ADH2-2; FAHD1; IL4I1; FAH; ALDH1A3; ALDH3A1; GSTZ1; TYR; GOT2A
    Phenylalanine metabolism AOC2; KEG1; GOT2; HPD; GOT2B; GOT1; AOC3; MAOA; ALDH3B1; ALDH1A3
    beta-Alanine metabolism ALDH3A1; HADHAB; ALDH7A1; ALDH1B1; ALDH3A2; CNDP2; ALDH9A1A.1; SMOX; ALDH6A1; SRM
    Metabolism of xenobiotics by cytochrome P GSTA2; GSTA1; GSTM1; EPHX1; GSTA3; DHDH; GSTM5; GSTAL; AKR7A3; GSTT1
    Drug metabolism - cytochrome P UGT1A6A; GSTM4; GSTP1; MAOB; FMO1; MGST1.2; MAOA; UGT1A2; UGT1A4; GSTO1
    Metabolic pathways MAN1A; GKUP; HSD11B1; PRPS1; AMACR; RIMKLB; ALOX5A; PANK1; MGAT4A; ATP6V0D1
    Chemical carcinogenesis UGT1A6B; GSTM5; CYP1B1; CYP2C38; UGT1A9; UGT2A2; AHA-1; GSTT1; UGT2A3; UGT1A6

    aldh3a1 has several biochemical functions, for example, 3-chloroallyl aldehyde dehydrogenase activity, alcohol dehydrogenase (NADP+) activity, aldehyde dehydrogenase (NAD) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by aldh3a1 itself. We selected most functions aldh3a1 had, and list some proteins which have the same functions with aldh3a1. You can find most of the proteins on our site.

    Function Related Protein
    3-chloroallyl aldehyde dehydrogenase activity ALDH3A2B; ALDH3B2; ALDH3A1; ALDH3A2A; ALDH2.1; ALDH3B1; ALDH3A2; ALDH1A1; Aldh1a7; ALDH9A1
    alcohol dehydrogenase (NADP+) activity ALDH3A1; AKR1A1A; RDH14; AKR1A1B
    aldehyde dehydrogenase (NAD) activity ALDH9A1A.1; ALDH1L2; ALDH4A1; Aldh1a7; ALDH1B1; ALDH3B2; ALDH8A1; ALDH3A2; ALDH3A2A; ALDH1L1
    aldehyde dehydrogenase [NAD(P)+] activity ALDH3A2B; ALDH2; ALDH3A2; ALDH3A2A; ALDH1A3; ALDH3A1; ALDH3B1; ALDH3B2
    benzaldehyde dehydrogenase (NAD+) activity Aldh1a7; ALDH3A1; ALDH1A1
    protein binding OIP5; BAG4; Icosl; TBX22; GGA2; DNAJC27; TECPR2; CD74; HBA2; SMAD9

    aldh3a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with aldh3a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of aldh3a1.

    POT1; SRF; CYHR1

    Kurita, H; Schnekenburger, M; et al. The Ah Receptor Recruits IKK alpha to Its Target Binding Motifs to Phosphorylate Serine-10 in Histone H3 Required for Transcriptional Activation. TOXICOLOGICAL SCIENCES 139:121-132(2014).
    Chiang, CP; Wu, CW; et al. Expression Pattern, Ethanol-Metabolizing Activities, and Cellular Localization of Alcohol and Aldehyde Dehydrogenases in Human Small Intestine. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH 36:2047-2058(2012).

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