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  • Official Full Name

    angiopoietin-like 2

  • Overview

    Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
  • Synonyms

    ANGPTL2; angiopoietin-like 2; ARP2; HARP; angiopoietin-related protein 2; angiopoietin-like protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line
  • Wheat Germ
  • C
  • His
  • Avi
  • Flag
  • GST
  • hFc
  • His (Fc)
  • His|T7
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPTL2-90H Active Recombinant Human ANGPTL2, FLAG-tagged HEK293 Flag
Human ANGPTL2-26H Active Recombinant Human ANGPTL2 Protein, His-tagged Mouse myeloma cell line His 23-493
Human ANGPTL2-396H Recombinant Human ANGPTL2, Fibrinogen-like Domain, FLAG-tagged HEK293 Flag
Human ANGPTL2-395H Recombinant Human ANGPTL2, Coiled-Coil Domain, FLAG-tagged HEK293 Flag
Human ANGPTL2-1972H Recombinant Human ANGPTL2 protein, His-tagged E.coli His Ser267~His493
Human ANGPTL2-554H Recombinant Human ANGPTL2 protein, GST-tagged Wheat Germ GST
Human ANGPTL2-0139H Recombinant Human ANGPTL2 Protein (Ser267-His493), His-tagged E.coli His Ser267-His493
Human ANGPTL2-014H Recombinant Human ANGPTL2 Protein, Thr260-His493, C-His-Avi tagged, Biotinylated HEK293 C-His-Avi Thr260-His493
Human ANGPTL2-472H Recombinant Human ANGPTL2 Protein (Asp245-His493), His-tagged HEK293 His Asp245-His493
Human ANGPTL2-4942H Recombinant Human ANGPTL2 protein, His-SUMO-tagged E.coli His-SUMO 23-493aa
Human ANGPTL2-1151HF Recombinant Full Length Human ANGPTL2 Protein, GST-tagged In Vitro Cell Free System GST 493 amino acids
Mouse Angptl2-108M Recombinant Mouse Angptl2 Protein, His tagged HEK293 N-His
Mouse Angptl2-1973M Recombinant Mouse Angptl2 protein, His & T7-tagged E.coli His/T7 Ser267~His493
Mouse Angptl2-109M Recombinant Mouse Angptl2 protein, His-tagged Insect Cell His 20-493 aa
Mouse ANGPTL2-106M Recombinant Mouse ANGPTL2 protein, hFc-tagged HEK293 hFc Asp245-His493
Mouse ANGPTL2-772MCL Recombinant Mouse ANGPTL2 cell lysate Human Cell N/A
Mouse Angptl2-15M Active Recombinant Mouse Angptl2 Protein, His-tagged Mammalian cells His
Mouse Angptl2-530M-B Recombinant Mouse Angptl2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Angptl2-530M Recombinant Mouse Angptl2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Angptl2-1974R Recombinant Rat Angptl2 protein, His-tagged E.coli His Ala47~Val207 (Accession # Q9JJ03)
Chicken ANGPTL2-5072C Recombinant Chicken ANGPTL2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANGPTL2 Related Articles
  • ANGPTL2 Related Research Area

ANGPTL2 involved in several pathways and played different roles in them. We selected most pathways ANGPTL2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ANGPTL2 has several biochemical functions, for example, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL2 itself. We selected most functions ANGPTL2 had, and list some proteins which have the same functions with ANGPTL2. You can find most of the proteins on our site.

Function Related Protein

ANGPTL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL2.


Sato, R; Yamasaki, M; et al. Angiopoietin-like protein 2 induces androgen-independent and malignant behavior in human prostate cancer cells. ONCOLOGY REPORTS 33:58-66(2015).
Deng, M; Lu, ZG; et al. A motif in LILRB2 critical for Angptl2 binding and activation. BLOOD 124:924-935(2014).
  • Q&As
  • Reviews

Q&As (16)

Ask a question
Are there any ongoing clinical trials targeting Angptl2 protein? 06/27/2022

Yes, there are several ongoing or completed clinical trials investigating the therapeutic potential of targeting Angptl2 in various diseases. These trials are primarily focused on cardiovascular diseases, metabolic disorders, and cancer. However, it is important to note that the results of these trials are still awaited and the therapeutic use of Angptl2 inhibitors is not yet approved.

Does Angptl2 protein have any role in wound healing? 05/30/2022

Angptl2 protein has been shown to play a role in wound healing, particularly in the process of tissue remodeling. It is involved in angiogenesis, which is essential for supplying nutrients and oxygen to the healing wound. Additionally, Angptl2 regulates the migration and activation of fibroblasts, which are key cells involved in wound healing.

Are there any genetic mutations associated with Angptl2 protein? 03/18/2022

At present, no specific genetic mutations directly associated with Angptl2 protein have been reported. However, there may be variations in the Angptl2 gene that could influence its expression or function, and further research is needed to understand the genetic factors related to Angptl2.

How does Angptl2 protein contribute to inflammation? 04/10/2021

Angptl2 protein can induce the production of inflammatory molecules and cell adhesion molecules, thereby promoting the migration and activation of immune cells. It is thought to contribute to chronic inflammation observed in various diseases, such as atherosclerosis and rheumatoid arthritis.

Is there any link between Angptl2 protein and obesity? 11/26/2020

Yes, Angptl2 has been implicated in obesity and associated metabolic disorders. Studies have shown that elevated Angptl2 levels in obese individuals are associated with insulin resistance, inflammation, and adverse metabolic outcomes. It is believed that Angptl2 may contribute to the development of obesity-related complications.

Is Angptl2 protein involved in neurodegenerative diseases? 07/12/2020

There is some evidence suggesting a potential involvement of Angptl2 in neurodegenerative diseases. Studies have shown that Angptl2 levels are increased in the brains of Alzheimer's disease patients and may contribute to the progression of neuroinflammation and neuronal damage. However, more research is needed to fully understand the role of Angptl2 in neurodegenerative diseases.

Can Angptl2 protein be used as a therapeutic target? 10/18/2018

Yes, Angptl2 is considered a potential therapeutic target for various diseases. Inhibitors targeting Angptl2 have shown promise in preclinical studies and have been investigated as potential treatments for conditions like atherosclerosis, diabetes, and cancer. However, more research is needed to establish their efficacy and safety in clinical settings.

Are there any known inhibitors or activators of Angptl2 protein? 12/24/2017

Researchers have identified various inhibitors of Angptl2, including antibodies and small molecules, which show promise as potential therapeutic agents. Activators of Angptl2 are not well-studied and understood at present.

Can Angptl2 protein be used as a biomarker for disease diagnosis or prognosis? 01/08/2017

Angptl2 has been investigated as a potential biomarker for various diseases. In conditions such as cardiovascular diseases, diabetes, and cancer, increased levels of Angptl2 have been detected in blood samples of affected individuals. These elevated Angptl2 levels have been associated with disease severity and poor prognosis. However, further research is needed to establish the clinical utility and reliability of Angptl2 as a biomarker.

Can Angptl2 protein be used as a diagnostic marker? 07/04/2016

Elevated levels of Angptl2 protein have been observed in certain diseases, so it holds potential as a diagnostic biomarker. However, more research is needed to establish its clinical utility and specificity as a diagnostic tool.

Can Angptl2 protein be targeted for the treatment of cardiovascular diseases? 05/02/2016

Yes, Angptl2 has emerged as a potential therapeutic target for cardiovascular diseases. In preclinical studies, inhibiting Angptl2 has been shown to reduce atherosclerosis, cardiac remodeling, and vascular dysfunction. These findings suggest that Angptl2 inhibition may have beneficial effects on cardiovascular health. Clinical trials are ongoing to further evaluate the efficacy and safety of targeting Angptl2 in cardiovascular disease treatment.

What are the potential roles of Angptl2 protein in cancer? 04/20/2016

Angptl2 has been implicated in cancer progression and metastasis. It is thought to promote tumor angiogenesis by stimulating the growth of blood vessels within tumors. Additionally, Angptl2 can enhance cancer cell migration and invasion, facilitating the spread of tumor cells to distant sites. In some cancers, high levels of Angptl2 have been associated with poor prognosis and worse outcomes. Targeting Angptl2 may therefore have potential therapeutic benefits in cancer treatment.

Is Angptl2 protein associated with any diseases? 02/24/2016

Yes, elevated levels of Angptl2 have been observed in several diseases, including cardiovascular diseases, diabetes, obesity, and certain types of cancer. It is considered a potential biomarker and therapeutic target for these conditions.

What are the implications of Angptl2 protein in cancer? 02/05/2016

Angptl2 protein is known to be involved in tumor progression and metastasis. It promotes angiogenesis, enhances tumor cell migration, and facilitates the invasion of cancer cells into surrounding tissues.

What are the functions of Angptl2 protein? 01/13/2016

Angptl2 protein has been implicated in several functions. It plays a role in promoting inflammation, regulating angiogenesis (the formation of new blood vessels), and modulating glucose and lipid metabolism.

How is Angptl2 protein regulated in the body? 01/13/2016

The expression and activity of Angptl2 protein can be regulated by various factors, including cytokines, hormones, and signaling pathways. For example, inflammatory cytokines such as TNF-alpha and IL-1beta can upregulate the expression of Angptl2. Hormones like estrogen and insulin can also affect Angptl2 expression. Additionally, the NF-κB and JAK/STAT signaling pathways have been shown to play a role in regulating Angptl2 levels.

Customer Reviews (4)

Write a review

    The manufacturer maintains stringent quality control measures to ensure the purity and stability of the protein, minimizing experimental variability and maximizing the accuracy of the data obtained.


      the manufacturer's support plays a crucial role in the successful implementation of trials involving the Angptl2 protein.


        Another advantage of the Angptl2 protein is its reliability and consistency, ensuring robust and reproducible results.


          the Angptl2 protein demonstrates significant relevance and potential in various trial applications, primarily focusing on inflammation, angiogenesis, and tissue remodeling.

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