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  • Official Full Name

    angiopoietin-like 6

  • Overview

    The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels from pre-existing blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. In addition, there are a number of proteins that are closely related to angiopoietins (ANGPTL2, ANGPTL3, ANGPTL4, ANGPTL5, ANGPTL6, ANGPTL7). Ang1 and Ang2 are required for the formation of mature blood vessels, as demonstrated by mouse knock out studies.
  • Synonyms

    UNQ152/PRO178; AGF; ARP5; angiopoietin-like protein 6; angiopoietin-related growth factor; angiopoietin-related protein 5; angiopoietin-related protein 6;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Wheat Germ
  • Flag
  • FLAG
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANGPTL6-408H Recombinant Human Angiopoietin-like 6, FLAG-tagged Human Cell Flag
Human ANGPTL6-559H Recombinant Human ANGPTL6 protein, GST-tagged Wheat Germ GST
Human ANGPTL6-26346TH Recombinant Human ANGPTL6, FLAG-tagged HEK293 FLAG 240 amino acids
Human ANGPTL6-26577TH Recombinant Human ANGPTL6, FLAG-tagged HEK293 FLAG 450 amino acids
Human ANGPTL6-1453H Recombinant Human ANGPTL6 protein, His & T7-tagged E.coli His/T7 Trp257~Leu470 (Accession # Q8NI99)
Mouse ANGPTL6-1641M Recombinant Mouse ANGPTL6 Protein Mammalian Cell His
Mouse ANGPTL6-531M Recombinant Mouse ANGPTL6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ANGPTL6-531M-B Recombinant Mouse ANGPTL6 Protein Pre-coupled Magnetic Beads HEK293
Mouse Angptl6-1454M Recombinant Mouse Angptl6 protein, His-tagged E.coli His Thr238~Leu457 (Accession # Q8R0Z6)
Rat Angptl6-1455R Recombinant Rat Angptl6 protein, His & T7-tagged E.coli His/T7 Thr238~Leu457 (Accession # B2RYM1)
Zebrafish ANGPTL6-2291Z Recombinant Zebrafish ANGPTL6 Mammalian Cell His
  • ANGPTL6 Related Research Area

ANGPTL6 involved in several pathways and played different roles in them. We selected most pathways ANGPTL6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANGPTL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ANGPTL6 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by ANGPTL6 itself. We selected most functions ANGPTL6 had, and list some proteins which have the same functions with ANGPTL6. You can find most of the proteins on our site.

Function Related Protein

ANGPTL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANGPTL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANGPTL6.

  • Q&As
  • Reviews

Q&As (11)

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Does ANGPTL6 have any role in insulin signaling? 07/02/2022

Yes, ANGPTL6 has been found to interact with insulin receptors and affect insulin signaling. It has been shown to enhance insulin sensitivity and glucose uptake in muscle cells, suggesting that ANGPTL6 may play a role in regulating glucose metabolism.

How does ANGPTL6 regulate lipid metabolism? 07/05/2021

ANGPTL6 has been shown to regulate lipid metabolism by inhibiting lipoprotein lipase (LPL), an enzyme that breaks down triglycerides in circulation. By inhibiting LPL, ANGPTL6 reduces the uptake of triglycerides from circulating lipoproteins into tissues, promoting the storage of triglycerides in adipose tissue.

Are there any genetic mutations or polymorphisms associated with ANGPTL6? 06/22/2021

Currently, there is limited research on genetic variations in the ANGPTL6 gene and their association with diseases or phenotypes. More studies are needed to understand the impact of genetic variations in ANGPTL6 and their potential functional consequences.

Are there any known interacting proteins or ligands of ANGPTL6? 07/16/2019

ANGPTL6 can interact with various proteins and receptors. It has been shown to interact with integrin receptors, such as α5β1 and αVβ3, which are present on endothelial cells and play a role in angiogenesis. ANGPTL6 may also interact with other angiopoietin-like proteins, such as ANGPTL4, forming heterodimers that modulate their functions. Additionally, ANGPTL6 can interact with insulin receptors and affect insulin signaling.

Are there any therapeutic applications for targeting ANGPTL6? 08/07/2018

Targeting ANGPTL6 has shown potential therapeutic applications. Inhibition of ANGPTL6 has been explored as a strategy to counteract obesity and improve glucose metabolism in preclinical studies. Additionally, targeting ANGPTL6 may have implications for cancer treatment, as it is involved in tumor angiogenesis. However, more research is needed to fully understand the therapeutic potential and safety of targeting ANGPTL6 in these contexts.

Is ANGPTL6 linked to obesity and type 2 diabetes? 08/01/2018

Yes, ANGPTL6 has been associated with obesity and type 2 diabetes. Studies have shown that ANGPTL6 expression is elevated in adipose tissue of obese individuals and those with type 2 diabetes. It is believed to contribute to dyslipidemia and insulin resistance, which are key factors in the development of obesity and type 2 diabetes.

Can ANGPTL6 be targeted for therapeutic purposes? 01/17/2018

ANGPTL6 has shown potential as a therapeutic target in certain diseases, particularly cancer. Inhibiting ANGPTL6 may help reduce tumor growth and metastasis. However, further research is needed to fully understand its therapeutic potential and any potential side effects before it can be targeted for therapeutic purposes.

Are there any known genetic mutations in the ANGPTL6 gene? 01/12/2018

Yes, there have been some genetic mutations identified in the ANGPTL6 gene. These mutations can lead to various disorders, such as primary ciliary dyskinesia, which affects the structure and function of cilia, and familial combined hyperlipidemia, which is characterized by abnormal lipid levels in the blood. However, the specific impact of these mutations on ANGPTL6 function and disease development is still being studied.

How is ANGPTL6 involved in angiogenesis? 02/09/2017

ANGPTL6 has been shown to promote angiogenesis, which is the formation of new blood vessels. It plays a role in endothelial cell proliferation, migration, and tube formation, which are all essential steps in the angiogenesis process. ANGPTL6 interacts with integrin receptors on endothelial cells, activating signaling pathways that promote angiogenesis.

Can ANGPTL6 be used as a biomarker for certain diseases? 12/28/2016

ANGPTL6 has been investigated as a potential biomarker for various diseases. Elevated levels of ANGPTL6 have been detected in the blood of patients with certain types of cancer, including colorectal cancer, gastric cancer, and hepatocellular carcinoma. However, more research is needed to determine its diagnostic and prognostic value as a biomarker.

Can ANGPTL6 be targeted for diagnostic purposes? 02/21/2016

ANGPTL6 has potential as a diagnostic biomarker for certain diseases. Its elevated expression levels in the blood have been associated with various types of cancer, including colorectal cancer, gastric cancer, and hepatocellular carcinoma. Detecting ANGPTL6 levels in the blood may therefore be useful for cancer diagnosis and prognosis. However, further research is required to establish its clinical utility and determine any potential limitations.

Customer Reviews (4)

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    They actively listen to my experimental needs and tailor their services accordingly, recognizing the unique requirements of my research.


      the ANGPTL6 protein is of exceptional quality, perfectly suiting my experimental needs.


        The manufacturer's excellent technical support, commitment to innovation, and customer-centric approach position them as an invaluable resource.


          This collaborative partnership contributes to a productive and efficient research experience, as I can rely on their expertise and assistance throughout the process.

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