ATP1A1
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Official Full Name
ATPase, Na+/K+ transporting, alpha 1 polypeptide
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Overview
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. -
Synonyms
ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha;
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- Involved Pathway
- Protein Function
- Interacting Protein
ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | ATP2A1;NFATC3;ROCK2;OPRD1;SLC25A4;SRF;IRS4;PPP1R12A;CALML3 |
| cAMP signaling pathway | GNAS;VAV2;GPR119;CALM1;PPARA;MAPK1;GNAI2;GABBR2;BAD |
| Cardiac muscle contraction | MYL3;TPM4;COX5AA;ATP1A2;COX7A2L;ACTC1B;CACNG2A;CACNA1SB;CACNB2A |
| Adrenergic signaling in cardiomyocytes | CACNA1SB;PRKACA;PLCB2;PPP2R5B;MYL4;CALM1A;ADCY2B;AKT3A;CAMK2G1 |
| Insulin secretion | PLCB3;ATP1B1;INS1;PLCB4;SNAP25;CAMK2B;ITPR3;FXYD2;CAMK2G |
| Thyroid hormone synthesis | CREB3L1;GPX3;TG;CREB5;ATP1B2;CREB3L2;GPX8;ATF4;ATP1A4 |
| Thyroid hormone signaling pathway | NCOA3;TBC1D4;ITGAV;MED4;PLCZ1;RAF1;PRKACA;AKT1;PRKACG |
| Aldosterone-regulated sodium reabsorption | PRKCG;PIK3CA;INS;PDPK1;INS1;SCNN1G;ATP1A2;ATP1B2;FXYD4 |
| Endocrine and other factor-regulated calcium reabsorption | GNAQ;KLK1B1;ATP1B1;SLC8A1;ATP1B3;PRKCA;KLK1B8;PRKCB;ATP1A3 |
| Proximal tubule bicarbonate reclamation | ATP1A1;Car4;CA4;ATP1A3;FXYD2;ATP1B4;CA2;PCK2;ATP1B3 |
| Salivary secretion | PRKACA;HTN1;VAMP2;CALM4;CALML5;MUC7;ATP1B1;STATH;ATP1B3 |
| Gastric acid secretion | KCNJ16;EZR;GNAI1;CA2;ATP1B2;PLCB1;ATP1A3;CALM3;CAMK2B |
| Pancreatic secretion | FXYD2;RAB8A;ATP1A1;AMY2A;RAC1;CPA2;KCNMA1;CLCA3;PRSS3 |
| Carbohydrate digestion and absorption | AMY2A4;PRKCB;PIK3R3;FXYD2;PLCB2;PIK3CA;ATP1A1;ATP1B2;ATP1B4 |
| Protein digestion and absorption | CTRL;ACE2;CPA3;COL18A1;CELA3A;ATP1A1;PRSS3;KCNJ13;KCNQ1 |
| Bile secretion | SLCO1B1;ATP1B2;SLC4A4;SLCO1B2;ABCB11;AQP9;OSTA;BAAT;SLC10A1 |
| Mineral absorption | TRPM6;SLC30A1;SLC34A2;SLC11A1;ATP1B3;CYBRD1;ATP1A2;HEPH;SLC11A2 |
ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ADP binding | PRPS2;GCLC;ERN1;PRKAG2;GLUD2;PKM;MYO7A;ACTA1;APAF1 |
| ATP binding | SPATA5;ACSM5;MYH11A;AK2;OLA1;PAPSS2;NADK;PRPS1;HSP90B1 |
| ankyrin binding | SCN5A;RHBG;ATP1A1;NRCAM;SLC8A1;SLC4A1;PLEC;SPTBN1;RHAG |
| chaperone binding | TRP53;USP13;GRPEL2;VWF;HSCB;TP53;DNAJB2;BAK1;PFDN6 |
| phosphatase activity | CTDSPLB;PTPRUB;PTPN22;CTDNEP1B;PHOSPHO1;PTP4A2A;SACM1LB;PTP4A2B;TIGARA |
| phosphatidylinositol 3-kinase binding | IRS2;INSRR;PDGFRB;IRS4;INSRB;CALM1;FLT3;IGF1RB;CALM3 |
| potassium ion binding | PKM2;KCNJ11;SLC24A1;PKLR;SLC24A5;PKM;ATP1A1;KCNA4;PKMA |
| protein binding | ARMC8;MTMR7;SKIV2L2;EDDM3B;NISCH;KCNJ3;HIST1H3F;PIH1D3;IL28RA |
| protein domain specific binding | IKBKG;EHD2;ST13;TFDP2;KCNN2;ICA1L;TWIST2;NEDD4;NFE2L2 |
| protein kinase binding | ACTA2;CYLD;TRIM6;CALM1;HSP90AB1;RAD9;NPM1;TRAF6;ACSL3 |
| sodium ion binding | SLC24A4A;PDXK;SLC24A1;SLC24A2;SCN9A;SLC24A4;CAPN3;SLC34A2;ATP1A1 |
| sodium:potassium-exchanging ATPase activity | ATP1A1A.1;ATP1A1A.2;ATP1A1B;ATP1A1A.5;ATP1A3;ATP12A;ATP1A1A.3;ATP1B2;ATP4A |
| contributes_to sodium:potassium-exchanging ATPase activity | ATP1B1;ATP1B3;ATP1A1;ATP1A2;ATP1B2 |
| steroid hormone binding | ESR2B;ATP1A1;NR3C1;GPR30;ATP1A2;ESR2A;ATP1A3 |
ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.
TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14
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