ATP1A1

  • Official Full Name

    ATPase, Na+/K+ transporting, alpha 1 polypeptide

  • Overview

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • Synonyms

    ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1A1-293H Recombinant Human ATP1A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP1A1-10004H Recombinant Human ATP1A1, His-tagged E.coli His 346-680a.a.
Human ATP1A1-8613HCL Recombinant Human ATP1A1 293 Cell Lysate HEK293 N/A
Human ATP1A1-460H Recombinant Human ATP1A1 Protein, His-tagged E.coli His His493~Ala660
Human ATP1A1-399H-B Recombinant Human ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Human ATP1A1-0551H Recombinant Human ATP1A1 Protein (Thr347-Asp680), N-His-tagged E.coli N-His Thr347-Asp680
Human ATP1A1-301593H Recombinant Human ATP1A1 protein, GST-tagged E.coli GST Thr347-Asp680
Human ATP1A1-399H Recombinant Human ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP1A1-379HFL Recombinant Full Length Human ATP1A1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse ATP1A1-2113M Recombinant Mouse ATP1A1 Protein Mammalian Cell His
Mouse ATP1A1-848M-B Recombinant Mouse ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse ATP1A1-848M Recombinant Mouse ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A1-852R Recombinant Rat ATP1A1 Protein Mammalian Cell His
Rat ATP1A1-508R Recombinant Rat ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A1-508R-B Recombinant Rat ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Rabbit ATP1A1-461R Recombinant Rabbit ATP1A1 Protein, His-tagged E.coli His Thr339~Leu772
Rhesus Macaque ATP1A1-446R Recombinant Rhesus monkey ATP1A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP1A1-275R Recombinant Rhesus Macaque ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATP1A1-275R-B Recombinant Rhesus Macaque ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ATP1A1-7070C Recombinant Chicken ATP1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayVDAC2;IRS4;PPP3R2;PLN;ROCK2;CALM4;PDE2A;GNA12;SLC25A6
cAMP signaling pathwayGRIN2D;CAMK2G;GRIN3A;RELA;HCAR3;GRIA2;GRIN3B;PRKACA;ATP2B4
Cardiac muscle contractionCACNA1C;COX8C;ATP1A4;ATP1B3B;COX6B1;COX6A2;CACNG6;ACTC1A;COX4I2
Adrenergic signaling in cardiomyocytesCACNG7;CREB3L2;PPP2CA;SCN4BA;CAMK2B;MYL3;CACNG2A;TPM4;MAPK1
Insulin secretionPRKCA;ATP1A3;INS;Adcy4;ATP1A4;SLC2A2;CREB3L3;GNA11;CAMK2D
Thyroid hormone synthesisTSHR;GPX1;TPO;PRKCA;ITPR3;PLCB3;PAX8;CREB3L2;GPX5
Thyroid hormone signaling pathwayWNT4;NRAS;PLCB3;PRKCG;ATP1A4;SLC16A10;PLCD1;RAF1;ACTB
Aldosterone-regulated sodium reabsorptionPRKCA;NR3C2;PIK3CA;MAPK3;INS;ATP1B2;PIK3CB;ATP1A4;PRKCB
Endocrine and other factor-regulated calcium reabsorptionKLK1B9;KLK1B8;ATP1A4;TRPV5;GNAS;KLK1B1;ATP1A3;PTH1R;PRKCB
Proximal tubule bicarbonate reclamationAQP1;SLC4A4;SLC25A10;ATP1B3;PCK1;ATP1A2;ATP1A1;FXYD2;Car2
Salivary secretionPRKACB;HTN1;GNAQ;ATP1A3;PLCB3;PRKG2;LYZ1;VAMP2;LYZ
Gastric acid secretionMYLK;KCNJ15;Car2;GNAS;ATP1B3;SLC9A1;MYLK4;PRKCA;GNAI1
Pancreatic secretionATP2B1;SLC26A3;PLCB3;FXYD2;ITPR1;PNLIPRP1;TPCN2;PNLIPRP2;SLC9A1
Carbohydrate digestion and absorptionATP1A3;SLC37A4;G6PC;TAS1R2;G6PC3;PIK3R3;PLCB2;AKT2;HK3
Protein digestion and absorptionMME;PRSS2;MEP1B;ATP1A4;SLC9A3;CPB2;CELA3B;KCNQ1;COL10A1
Bile secretionOSTB;HMGCR;ATP1B2;LDLR;SCTR;ADCY8;ADCY6;AQP8;SLC27A5
Mineral absorptionATP1A4;SLC8A1;MT1E;SLC30A1;FXYD2;SLC34A2;MT1A;MT1G;SLC26A3

ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingMYH10;ABCG1;MYH9;MYO9B;GCLC;ME1;TAP1;PRPS2;ADCK3
ATP bindingACSM4;PRKY;PIP5K1A;CHKA;DNAJA1;NEK7;GUCY2C;NAV3;MOCS3
ankyrin bindingSPTBN1;FLNC;KCTD6;RHCG;SCN5A;OBSCN;KCNJ11;RHBG;SLC4A1
chaperone bindingDNAJB2;DNAJB1;ATP1A1;DNAJB5;SLC25A17;HSPA5;PRNP;TIMM9;USP13
phosphatase activityPTPN11B;C12orf5;CDC14AA;PTP4A2A;ALPI.2;CTDSPLA;DUSP28;MTMR1B;MINPP1A
phosphatidylinositol 3-kinase bindingCALM2;CALM1;INSRR;JAK2;PDGFRB;HCST;IGF1RA;INSRB;TYRO3
potassium ion bindingSLC24A4A;PDXK;PKM;HDAC4;SLC24A1;PKMA;SLC24A2;KCNJ11;SLC24A4
protein bindingDPPA4;FAM76B;EREG;DST;NUP54;MMP14;ADAMTSL4;UFD1L;PTPLAD1
protein domain specific bindingCNOT1;RCC2;NEDD4;YWHABL;FOXH1;MPP7;STXBP1;TJP1;NR0B2
protein kinase bindingBORA;SLC12A5;CALM3;BCAR1;TNIP2;SPDYB;MAML1;LATS1;TNNI3
sodium ion bindingPDXK;SLC34A2;SLC24A2;SLC24A1;CAPN3;SLC24A4A;ATP1A1;SLC24A5;SLC24A4
sodium:potassium-exchanging ATPase activityATP12A;ATP1B3;ATP1B2;ATP1A1A.1;ATP1A1A.3;ATP1A1A.5;ATP1A2;ATP4A;ATP1A3A
contributes_to sodium:potassium-exchanging ATPase activityATP1A2;ATP1A1;ATP1B3;ATP1B1;ATP1B2
steroid hormone bindingESR2A;GPR30;ATP1A1;ATP1A3;ATP1A2;ESR2B;NR3C1

ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.

TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14

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