ATP1A1

  • Official Full Name

    ATPase, Na+/K+ transporting, alpha 1 polypeptide

  • Overview

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
  • Synonyms

    ATP1A1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; sodium/potassium-transporting ATPase subunit alpha-1; sodium pump 1; Na+/K+ ATPase 1; Na,K-ATPase alpha-1 subunit; sodium pump subunit alpha-1; Na+, K+ ATPase alpha subunit; Na(+)/K(+) ATPase alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP1A1-293H Recombinant Human ATP1A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ATP1A1-10004H Recombinant Human ATP1A1, His-tagged E.coli His 346-680a.a.
Human ATP1A1-8613HCL Recombinant Human ATP1A1 293 Cell Lysate HEK293 N/A
Human ATP1A1-460H Recombinant Human ATP1A1 Protein, His-tagged E.coli His His493~Ala660
Human ATP1A1-399H-B Recombinant Human ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Human ATP1A1-0551H Recombinant Human ATP1A1 Protein (Thr347-Asp680), N-His-tagged E.coli N-His Thr347-Asp680
Human ATP1A1-301593H Recombinant Human ATP1A1 protein, GST-tagged E.coli GST Thr347-Asp680
Human ATP1A1-399H Recombinant Human ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ATP1A1-379HFL Recombinant Full Length Human ATP1A1 Protein, C-Flag-tagged Mammalian cells Flag
Mouse ATP1A1-2113M Recombinant Mouse ATP1A1 Protein Mammalian Cell His
Mouse ATP1A1-848M-B Recombinant Mouse ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Atp1a1-4353M Recombinant Mouse Atp1a1 protein, His-tagged E.coli N-His 341-775aa
Mouse ATP1A1-848M Recombinant Mouse ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A1-852R Recombinant Rat ATP1A1 Protein Mammalian Cell His
Rat ATP1A1-508R Recombinant Rat ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ATP1A1-508R-B Recombinant Rat ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Rabbit ATP1A1-461R Recombinant Rabbit ATP1A1 Protein, His-tagged E.coli His Thr339~Leu772
Rhesus Macaque ATP1A1-446R Recombinant Rhesus monkey ATP1A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ATP1A1-275R Recombinant Rhesus Macaque ATP1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ATP1A1-275R-B Recombinant Rhesus Macaque ATP1A1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ATP1A1-7070C Recombinant Chicken ATP1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ATP1A1 involved in several pathways and played different roles in them. We selected most pathways ATP1A1 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
cGMP-PKG signaling pathwayATP1B4;VDAC1;SLC25A6;SLC8A1;PRKG2;ATP1A2;PPP3R1;BDKRB2;GNA12
cAMP signaling pathwayPRKACA;PPP1CC;ATP1A2;PIK3CG;ATP2B1;FXYD1;GNAI3;MAP2K2;MLLT4
Cardiac muscle contractionTPMA;CACNA1D;FXYD2;COX7B2;UQCRC2A;CACNB2;CACNG6;CACNG3;CACNA2D1A
Adrenergic signaling in cardiomyocytesGNAQ;CACNG6A;MAPK3;ACTC1;AGTR1A;CALM2B;CAMK2A;CREB3L1;CALM3
Insulin secretionGNAS;PRKACA;KCNN1;PRKCG;GNA11;ATP1A2;ATP1B4;RIMS2;PLCB1
Thyroid hormone synthesisATP1A4;DUOXA2;CREB3L3;GPX8;ASGR2;PRKACB;CREB3L1;CANX;TPO
Thyroid hormone signaling pathwaySLC16A2;PLCB1;RXRG;KAT2B;MED13L;RXRB;TSC2;PRKACB;EP300
Aldosterone-regulated sodium reabsorptionINS2;SCNN1G;PIK3CB;ALPHA-ENAC;IRS1;MAPK1;ATP1A4;PIK3R1;PDPK1
Endocrine and other factor-regulated calcium reabsorptionKLK1B1;ESR1;DNM3;ATP1A3;TRPV5;PRKACA;GNAQ;KLK1B24;KLK1B9
Proximal tubule bicarbonate reclamationSLC38A3;SLC9A3;MDH1;PCK1;GLUD1;CA2;SLC4A4;ATP1A1;ATP1A4
Salivary secretionPRH1;PRKACB;AQP5;ATP1B2;RYR3;PRKCG;CAP18;PRKACG;ITPR1
Gastric acid secretionGNAI1;SLC9A4;ITPR1;ATP1A2;GAST;KCNE2;SSTR2;KCNJ1;ATP1B2
Pancreatic secretionCELA2A;RAP1A;CLCA5;ATP1B2;RYR2;PRKCB;Car2;CTRL;GNAS
Carbohydrate digestion and absorptionPIK3R3;TAS1R3;AMY1A;HK2;ATP1B2;AMY2B;SLC5A1;AKT1;SLC37A4
Protein digestion and absorptionKCNE3;ATP1B3;CELA3B;SLC7A8;ATP1B4;COL15A1;COL6A5;CELA2B;COL27A1
Bile secretionLDLR;SLC5A1;ADCY9;SLC9A3;ATP1A3;SLCO1B2;OSTA;ATP1A2;FXYD2
Mineral absorptionTRPV6;MT1X;HEPH;SLC11A2;ATP1B4;HMOX1;ATP1A1;SLC5A1;SLC26A3

ATP1A1 has several biochemical functions, for example, ADP binding, ATP binding, ankyrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP1A1 itself. We selected most functions ATP1A1 had, and list some proteins which have the same functions with ATP1A1. You can find most of the proteins on our site.

Function Related Protein
ADP bindingME1;ACTA1;PRKAG2;PRPS1;GLUD2;MYO6;MIEF1;MYO3A;MYH9
ATP bindingMAP3K13;DGKQ;UBE2D1;RPS6KC1;NLK2;CDK14;BAT1;OAS1B;VARS2
ankyrin bindingRHBG;SPTBN1;KCNJ11;CDH1;PTBP3;KCTD6;FLNC;SLC4A1;RHCG
chaperone bindingPARK2;Alb;C1orf182;INS1;BIRC5;PFDN4;DNAJB5;DNAJA3B;DNAJB6
phosphatase activityATP1A1;PTPN11B;CDC14AA;PGAM5;TIGARA;PTENB;CDC14AB;MTMR1B;TIGARB
phosphatidylinositol 3-kinase bindingFYN;JAK2;IGF1R;IRS1;IRS2;INSRA;FLT3;INSRB;HCST
potassium ion bindingSLC24A4;PKMA;ATP1A1;KCNJ11;HDAC4;PKM;PKLR;KCNA4;SLC24A4A
protein bindingZFYVE28;C2orf29;TUBA3C;APC;ECH1;FRA10AC1;GBP1;PRKCI;WBP1
protein domain specific bindingHPCAL4;MITD1;CASKIN1;NDE1;XPA;HIST1H4E;GNAI3;CHMP1A;DIXDC1
protein kinase bindingCAV1;FGFR1OP;CDK5RAP3;RAD9;IL12RB2;PEBP1;MAML1;RPS6;ERRFI1
sodium ion bindingPDXK;SLC24A2;SLC24A1;SLC24A4;SLC24A5;SLC34A2;CAPN3;SLC24A4A;ATP1A1
sodium:potassium-exchanging ATPase activityATP1B3;ATP1A2;ATP1A1A.2;ATP1A1A.1;ATP1A4;ATP1A1;ATP1A1A.4;FXYD2;ATP1A2A
contributes_to sodium:potassium-exchanging ATPase activityATP1A2;ATP1B1;ATP1B2;ATP1B3;ATP1A1
steroid hormone bindingATP1A1;GPR30;ESR2A;ESR2B;NR3C1;ATP1A3;ATP1A2

ATP1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP1A1.

TPT1; ERBB2; GTF2F2; TNFRSF1A; TNFRSF1B; Tpt1; TRADD; SMAD2; NDRG1; SNX6; SNAPIN; EZH2; 15-deoxy-delta(12,14

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