ATP6V0A1

  • Official Full Name

    ATPase, H+ transporting, lysosomal V0 subunit a1

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ATP6V0A1; ATPase, H+ transporting, lysosomal V0 subunit a1; ATP6N1, ATP6N1A, ATPase, H+ transporting, lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD) , ATPase, H+ transporting, lysosomal V0 subunit a isoform 1 , ATPase, H+ transporting, lysosomal V0 subunit A1 , VPP1; V-type proton ATPase 116 kDa subunit a isoform 1; a1; Stv1; Vph1; ATP6N1; ATP6N1A; ATPase H+ transporting lysosomal (vacuolar proton pump) non catalytic accessory protein 1A (110/116kD); ATPase H+ transporting lysosomal non catalytic accessory protein 1 (110/116kD); ATPase H+ transporting lysosomal V0 subunit a1; Clathrin coated vesicle/synaptic vesicle proton pump 116 kDa subunit; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; DKFZp781J1951; H(+) transporting two sector ATPase 116 kDa accessory protein A1; V ATPase 116 kDa; V ATPase 116 kDa isoform a1; V type proton ATPase 116 kDa subunit a; V type proton ATPase 116 kDa subunit a isoform 1; V-ATPase 116 kDa isoform a1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; Vacuolar proton pump, subunit 1; Vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; Vacuolar type H(+) ATPase 115 kDa subunit; VPP1; VPP1_HUMAN; V-ATPase 116 kDa; V-type proton ATPase 116 kDa subunit a; vacuolar-type H(+)-ATPase 115 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1A (110/116kD);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V0A1-994H Recombinant Human ATP6V0A1 protein, GST-tagged Wheat Germ GST
Human ATP6V0A1-8590HCL Recombinant Human ATP6V0A1 293 Cell Lysate HEK293 N/A
Human ATP6V0A1-1540HF Recombinant Full Length Human ATP6V0A1 Protein, GST-tagged In Vitro Cell Free System GST 831 amino acids
Human ATP6V0A1-2980H Recombinant Human ATP6V0A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Atp6v0a1-675M Recombinant Mouse Atp6v0a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat ATP6V0A1-885R Recombinant Rat ATP6V0A1 Protein Mammalian Cell His
Rat ATP6V0A1-541R-B Recombinant Rat ATP6V0A1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V0A1-541R Recombinant Rat ATP6V0A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ATP6V0A1-6289C Recombinant Chicken ATP6V0A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ATP6V0A1 Related Articles

ATP6V0A1 involved in several pathways and played different roles in them. We selected most pathways ATP6V0A1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V0A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFA11;ATP6V0E2;ctaG;SDHDA;NDUFB5;UQCR10;MT-ND4;ATP6V0A1A;COX7A1
Metabolic pathwaysACO2;POLR2A;POLR2G;CDO1;TPH1;NDUFA12;FH;GALNS;ATP5C1
LysosomeARSB;MCOLN1;ATP6V0A2B;M6PR;CTSBA;CTSW;DNASE2B;IDUA;ATP6V0A1B
PhagosomeATP6V0A2;TFRC;TUBA3A;ATP6V1E2;ATP6V0CB;THBS3A;HLA-DMB;HLA-DOB;FAM49BA
Synaptic vesicle cycleATP6V1H;NSF;ATP6V0D2;CPLX3;ATP6V1G2;ATP6V0A2;ATP6V1B2;ATP6V1A;UNC13A
Collecting duct acid secretionCA2;ATP6V1A;Car2;ATP6V1C1;SLC12A7;ATP6V1D;ATP4B;ATP6V0A4;ATP6V0D2
Vibrio cholerae infectionPLCG1;KDELR1;ATP6V1G1;ATP6V1B2;ACTG1;ATP6V1E1;KDELR2;ATP6V1D;ATP6AP1
Epithelial cell signaling in Helicobacter pylori infectionMAPK9;MAPK11;ATP6V1G3;MAP3K14;RELA;JAM3;MET;ATP6V0A1;ADAM17
TuberculosisH2-AB1;PPP3R2;IL6;TRADD;LSP1;HLA-DRB1;IFNA8;CD209;TLR1
Rheumatoid arthritisHLA-DMA;Ccl12;ATP6V0A4;ITGB2;HLA-DRA;ATP6V0D2;ATP6V0B;HLA-DPA1;CCL3L1

ATP6V0A1 has several biochemical functions, for example, ATPase binding, protein binding, proton-transporting ATPase activity, rotational mechanism. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V0A1 itself. We selected most functions ATP6V0A1 had, and list some proteins which have the same functions with ATP6V0A1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingESR1;FBL;PGR;PIH1D1;ALDOB;NHP2L1;NSFL1C;FXYD7;PLN
protein bindingSPON2;PRKCB;DHX9;POLE4;LAIR2;UBE2D3;JMJD6;RNF20;ADD1
proton-transporting ATPase activity, rotational mechanismATP6V1C1;ATP6AP1B;ATP6V0A1A;ATP6V1E1B;ATP6V0A1B;ATP6V0E1;ATP5B;ATP6V1AA;ATPV0E2

ATP6V0A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V0A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V0A1.

CLIC1; SNX4; ZNF267; SEH1L; ATP6V1A; CTSD; ATP6V1B1

Tuttle, AM; Hoffman, TL; et al. Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration. PLOS BIOLOGY 12:-(2014).
Valapala, M; Wilson, C; et al. Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/beta A3/A1-crystallin via V-ATPase-MTORC1 signaling. AUTOPHAGY 10:480-496(2014).
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