ATP6V1E1

  • Official Full Name

    ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1

  • Overview

    This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
  • Synonyms

    ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; ATP6E, ATP6V1E, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD , ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1; V-type proton ATPase subunit E 1; ATP6E2; P31; Vma4; ATP6E; ATP6V1E; V ATPase 31 kDa subunit; Vacuolar proton pump subunit E 1; OTTHUMP00000065606; OTTHUMP00000196213; OTTHUMP00000214152; OTTHUMP00000214153; V-ATPase, subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit; H+-transporting ATP synthase chain E, vacuolar; H(+)-transporting two-sector ATPase, 31kDa subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ATP6V1E1-10046H Recombinant Human ATP6V1E1, GST-tagged E.coli GST 1-226a.a.
Human ATP6V1E1-386H Recombinant Human ATP6V1E1, T7-tagged E.coli T7
Human ATP6V1E1-1006H Recombinant Human ATP6V1E1 protein, GST-tagged Wheat Germ GST
Human ATP6V1E1-8580HCL Recombinant Human ATP6V1E1 293 Cell Lysate HEK293 N/A
Human ATP6V1E1-1537HF Recombinant Full Length Human ATP6V1E1 Protein, GST-tagged In Vitro Cell Free System GST 226 amino acids
Mouse ATP6V1E1-2164M Recombinant Mouse ATP6V1E1 Protein Mammalian Cell His
Mouse Atp6v1e1-673M Recombinant Mouse Atp6v1e1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ATP6V1E1-880M Recombinant Mouse ATP6V1E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ATP6V1E1-880M-B Recombinant Mouse ATP6V1E1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1E1-893R Recombinant Rat ATP6V1E1 Protein Mammalian Cell His
Rat ATP6V1E1-549R-B Recombinant Rat ATP6V1E1 Protein Pre-coupled Magnetic Beads HEK293
Rat ATP6V1E1-549R Recombinant Rat ATP6V1E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ATP6V1E1-328C Recombinant Cynomolgus ATP6V1E1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ATP6V1E1-78C Recombinant Cynomolgus Monkey ATP6V1E1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey ATP6V1E1-78C-B Recombinant Cynomolgus Monkey ATP6V1E1 Protein Pre-coupled Magnetic Beads HEK293
Chicken ATP6V1E1-1393C Recombinant Chicken ATP6V1E1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ATP6V1E1 involved in several pathways and played different roles in them. We selected most pathways ATP6V1E1 participated on our site, such as Oxidative phosphorylation, Metabolic pathways, Phagosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATP6V1E1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Oxidative phosphorylationNDUFA13;ATP5G1;COX8C;NDUFB4;ATP6V0D1;ATP6AP1;NDUFA11;NDUFB1;NDUFS7
Metabolic pathwaysADSL;GALNT1;ALDOAB;ACSL3A;UGT1A6A;MAN1C1;DPM1;DNMT3A;MAN1B1
PhagosomeTUBB2;ITGB5;CTSSB.1;ITGB3;FCGR3A;CORO1A;TUBA1L;TAP2;STX18
Synaptic vesicle cycleCPLX2;ATP6V1C1;ATP6V0E2;NSF;SLC18A2;UNC13C;NAPA;ATP6V1C2;ATP6V0C
Collecting duct acid secretionATP4A;ATP6V1E1;ATP6V0A2;ATP6V1B2;ATP6V0E;ATP6V1E2;Car2;CA2;ATP6V0E2
Vibrio cholerae infectionATP6V1F;ATP6V1H;ACTG1;KDELR3;ATP6V1E1;ATP6V1B2;ATP6V0D2;ATP6V1G1;ATP6V1A
Epithelial cell signaling in Helicobacter pylori infectionMAP3K14;MAPK11;MAPK12;ADAM17;ATP6V1G1;RELA;ATP6V1H;NFKBIA;MAPK9
Rheumatoid arthritisFLT1;ATP6V0A2;Il23a; Il12b;CTLA4;ITGAL;CD80;ATP6V0B;TGFB1;MMP1A

ATP6V1E1 has several biochemical functions, for example, ATPase binding, hydrogen-exporting ATPase activity, phosphorylative mechanism, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATP6V1E1 itself. We selected most functions ATP6V1E1 had, and list some proteins which have the same functions with ATP6V1E1. You can find most of the proteins on our site.

Function Related Protein
ATPase bindingATPIF1;ATP6V1E1;DNAJB1;GABARAPL2;ATP6V0A2B;NSFL1C;PKD2;SDF2L1;SNX10
hydrogen-exporting ATPase activity, phosphorylative mechanismATP6V0D1;ATP6V1C1;ATP6V1G3;ATP6V1E2;ATP6V1C2;ATP6V1G1;ATP6V1E1
protein bindingITGB3B;TMEM25;CLSTN2;STX19;C17orf81;FOXR1;ITSN1;ABCB1;ERC2
proton-transporting ATPase activity, rotational mechanismATP6V1E1;ATP6V0E;ATP6V0A4;ATP6V1E2;ATP6V0E2;ATP6V0A1B;ATP6V0B;ATP6AP1B;ATP5B

ATP6V1E1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATP6V1E1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ATP6V1E1.

DEDD; ATP6V1G1; ATP6V1G2; XRCC6; MESDC2; pyrH; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; ATP6V1A; Rmdn3; Chmp4b; CHMP4B; GOLT1B

Research Area

Related articles

Yang, LS; Xu, XE; et al. iTRAQ-based quantitative proteomic analysis for identification of oligodendroglioma biomarkers related with loss of heterozygosity on chromosomal arm 1p. JOURNAL OF PROTEOMICS 77:480-491(2012).
Knijnenburg, J; van Bever, Y; et al. A 600 kb triplication in the cat eye syndrome critical region causes anorectal, renal and preauricular anomalies in a three-generation family. EUROPEAN JOURNAL OF HUMAN GENETICS 20:986-989(2012).
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