BRD8
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Official Full Name
bromodomain containing 8 -
Overview
The protein encoded by this gene interacts with thyroid hormone receptor in a ligand-dependent manner and enhances thyroid hormone-dependent activation from thyroid response elements. This protein contains a bromodomain and is thought to be a nuclear receptor coactivator. Three alternatively spliced transcript variants that encode distinct isoforms have been identified. -
Synonyms
BRD8;bromodomain containing 8;bromodomain-containing protein 8;p120;SMAP;trCP120;skeletal muscle abundant protein 2;thyroid hormone receptor coactivating protein of 120 kDa;SMAP2
Recombinant Proteins
- Zebrafish
- Chicken
- Mouse
- Human
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- His
- Non
- GST
- Avi
- Fc
- DDK
- Myc
Involved Pathway
BRD8 involved in several pathways and played different roles in them. We selected most pathways BRD8 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,HATs acetylate histones, which may be useful for your reference. Also, other proteins which involved in the same pathway with BRD8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin modifying enzymes | PRMT6,MEAF6,PRMT7,ZZZ3,KAT7,SAP18,CSRP2BP,MTA2,TADA1,CAPNS2 |
| HATs acetylate histones | ZZZ3,EP400,ATXN7L3,MSL2B,MSL1,VPS72,ENY2,KAT6A,MSL3,KANSL2 |
| Chromatin organization | BRD1,SMARCD3B,DMAP1,SAP30,KDM2B,SMARCD3,ING3,ARID2,KAT7A,PADI3 |
Protein Function
BRD8 has several biochemical functions, for example, protein binding,thyroid hormone receptor activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BRD8 itself. We selected most functions BRD8 had, and list some proteins which have the same functions with BRD8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | HNF1BB,HOXC5,OTX1B,DMRT2,ZNF302,NR5A2,NR4A2B,ZNF649,BLF,RB1 |
| protein binding | SMAD7,VARS,ALS2CR11,LUC7L,CARKD,GPBP1,SERBP1,POP7,HOXA1,TSHR |
| thyroid hormone receptor activity | NR2F6,THRA,THRB,NR1D2A,NR1I3,THRAA,NR1H4,NR4A3,NR1D4B,NR1D4A |
Interacting Protein
BRD8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BRD8 here. Most of them are supplied by our site. Hope this information will be useful for your research of BRD8.
MRGBP;ACTL6A;MORF4L2;EP400;MORF4L1;TRRAP;deoB;SNW1;VPS72;ESR2;CDC5L;RUVBL2;RUVBL1
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