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CA5B

  • Official Full Name

    carbonic anhydrase VB, mitochondrial

  • Overview

    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA.It has a wider tissue distribution than CA VA, which is restricted to the liver.The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles.
  • Synonyms

    CA5B; carbonic anhydrase VB, mitochondrial; carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA VB; carbonic dehydratase; CA-VB;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA5B-577H Active Recombinant Human CA5B Protein, His-tagged E.coli His Cys34-Pro317
Human CA5B-1125H Active Recombinant Human CA5B protein(Cys34-Pro317), His-tagged E.coli C-His Cys34-Pro317
Human CA5B-463H Recombinant Human CA5B Protein E.coli N/A
Human CA5B-10623H Recombinant Human CA5B, GST-tagged E.coli GST 1-317a.a.
Human CA5B-0243H Recombinant Human CA5B Protein, GST-Tagged Wheat Germ GST
Human CA5B-265HCL Recombinant Human CA5B cell lysate N/A
Human CA5B-2267H Recombinant Human CA5B Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA5B-2741HF Recombinant Full Length Human CA5B Protein, GST-tagged In Vitro Cell Free System GST 317 amino acids
Human CA5B-0154H Recombinant Human CA5B Protein (Cys34-Pro317), N-His-tagged E.coli N-His Cys34-Pro317
Mouse Car5b-7837M Recombinant Mouse Car5b protein, His-tagged E.coli His Arg63~Pro225 (Accession # Q9QZA0)
Mouse Car5b-1961M Recombinant Mouse Car5b Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat CAR5B-1135R Recombinant Rat CAR5B Protein Mammalian Cell His
Rat Ca5b-7838R Recombinant Rat Ca5b protein, His-tagged E.coli His Glu174~Thr311 (Accession # Q66HG6)
Rat CA5b-720R-B Recombinant Rat CA5b Protein Pre-coupled Magnetic Beads HEK293
Rat CA5b-720R Recombinant Rat CA5b Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA5B involved in several pathways and played different roles in them. We selected most pathways CA5B participated on our site, such as Metabolism, Nitrogen metabolism, Reversible hydration of carbon dioxide, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MetabolismAZIN1B;NDUFAF6;EPM2A;CYP19A1;ESRRA;CYP4T8;ARL2;CYP26A1;CA13
Nitrogen metabolismCA4;CA6;CA9;Car9;Car8;GLUD2;Car4;CAR3;CA7
Reversible hydration of carbon dioxideCA13;CA5B

CA5B has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA5B itself. We selected most functions CA5B had, and list some proteins which have the same functions with CA5B. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCA13;CA3;Car8;CA5;CAR1;CAR6;CA4B;CA8;Car12
zinc ion bindingRNF5;AIRE;RFWD2;MT1M;ING5B;FBXL19;SRSF7;APOBEC3F;RNF207

CA5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA5B here. Most of them are supplied by our site. Hope this information will be useful for your research of CA5B.

Research Area

Related articles

Durdagi, S; Scozzafava, G; et al. Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 29:469-475(2014).
van Karnebeek, CD; Sly, WS; et al. Mitochondrial Carbonic Anhydrase VA Deficiency Resulting from CA5A Alterations Presents with Hyperammonemia in Early Childhood. AMERICAN JOURNAL OF HUMAN GENETICS 94:453-461(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How do mutations in the CA5B gene potentially affect the protein's enzymatic function? 05/09/2022

Mutations might influence CA5B's enzymatic activity or protein stability, requiring comparative functional assays.

How does CA5B participate in cellular pH regulation and metabolism? 03/31/2020

CA5B aids in the reversible conversion of CO2 to bicarbonate and protons, essential for pH regulation and CO2 transport within cells.

What specific post-translational modifications are associated with CA5B? 11/12/2019

CA5B's post-translational modifications can be detected using mass spectrometry, with potential sites for phosphorylation or other modifications.

Are there any specific diseases or conditions linked with aberrant CA5B expression or function? 03/17/2018

Abnormal CA5B function or expression could impact metabolic homeostasis in tissues, potentially contributing to metabolic or neurological disorders.

Which human tissues or organs display the most significant expression of CA5B? 03/31/2017

CA5B is prominently expressed in the mitochondria of various tissues, including skeletal muscle and the brain.

How does the enzymatic function of CA5B distinguish it from other carbonic anhydrase isoforms? 03/06/2017

CA5B operates within mitochondrial environments, which may lead to specific enzymatic kinetics compared to cytosolic isoforms.

Are there any known direct inhibitors targeting CA5B's enzymatic activity? 01/22/2017

General carbonic anhydrase inhibitors might affect CA5B, but specific inhibitors for CA5B would need exploration.

Customer Reviews (3)

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Reviews
10/23/2022

    Dependable source for all research-related necessities.

    01/02/2021

      Professional support team, quick to respond and assist.

      12/14/2020

        Precision in protein characterization, unmatched excellence.

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