CA5B
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Official Full Name
carbonic anhydrase VB, mitochondrial
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Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA.It has a wider tissue distribution than CA VA, which is restricted to the liver.The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. -
Synonyms
CA5B; carbonic anhydrase VB, mitochondrial; carbonic anhydrase 5B, mitochondrial; Carbonate dehydratase VB; Carbonic anhydrase VB; CA VB; carbonic dehydratase; CA-VB;
- Recombinant Proteins
- Cell & Tissue Lysates
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- Involved Pathway
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- Interacting Protein
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CA5B involved in several pathways and played different roles in them. We selected most pathways CA5B participated on our site, such as Metabolism, Nitrogen metabolism, Reversible hydration of carbon dioxide, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | ATP5S;MTP;CYP3A7-CYP3AP1;ADAL;B3GNT2A;DPEP2;SULT4A1;CYP3C4;CYP2K16 |
| Nitrogen metabolism | GLUD1;CA1;GLUD1A;Car8;CA5;GLUL;CA4B;GLULA;CAR3 |
| Reversible hydration of carbon dioxide | CA13;CA5B |
CA5B has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA5B itself. We selected most functions CA5B had, and list some proteins which have the same functions with CA5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CA9;Car14;CA4A;CA2;Car9;CA15B;CA5B;CAR1;CA3 |
| zinc ion binding | CAR3;EDEM3;TRIP6;TRIM55B;UBR7;NPEPPS;ADAMTSL1;ADAT2;NBR1 |
CA5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA5B here. Most of them are supplied by our site. Hope this information will be useful for your research of CA5B.
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Q&As (7)
Ask a questionMutations might influence CA5B's enzymatic activity or protein stability, requiring comparative functional assays.
CA5B aids in the reversible conversion of CO2 to bicarbonate and protons, essential for pH regulation and CO2 transport within cells.
CA5B's post-translational modifications can be detected using mass spectrometry, with potential sites for phosphorylation or other modifications.
Abnormal CA5B function or expression could impact metabolic homeostasis in tissues, potentially contributing to metabolic or neurological disorders.
CA5B is prominently expressed in the mitochondria of various tissues, including skeletal muscle and the brain.
CA5B operates within mitochondrial environments, which may lead to specific enzymatic kinetics compared to cytosolic isoforms.
General carbonic anhydrase inhibitors might affect CA5B, but specific inhibitors for CA5B would need exploration.
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