CREB5
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Official Full Name
cAMP responsive element binding protein 5 -
Overview
The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family;contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a;heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript;variants encoding different isoforms have been identified. -
Synonyms
CREB5;cAMP responsive element binding protein 5;cyclic AMP-responsive element-binding protein 5;cAMP response element binding protein CRE Bpa;CRE BPA;H_GS165L15.1;CREB-5;cAMP-responsive element-binding protein 5;cAMP response element binding prote
Recombinant Proteins
- Human
- Mouse
- E.coli
- Wheat Germ
- Mammalian Cells
- HEK293
- In Vitro Cell Free System
- His
- T7
- GST
- Non
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CREB5-1112H | Recombinant Human CREB5 protein, His & T7-tagged | E.coli | Human | His&T7 | Gln308~Leu508 |
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| CREB5-1850H | Recombinant Human CREB5 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CREB5-3892M | Recombinant Mouse CREB5 Protein | Mammalian Cells | Mouse | His |
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| CREB5-7286HCL | Recombinant Human CREB5 293 Cell Lysate | HEK293 | Human | Non |
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| CREB5-1968M | Recombinant Mouse CREB5 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| CREB5-1968M-B | Recombinant Mouse CREB5 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| CREB5-2282HF | Recombinant Full Length Human CREB5 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 508 amino acids |
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| Creb5-5532M | Recombinant Mouse Creb5 protein, His-tagged | E.coli | Mouse | His | 1-357a.a. |
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Involved Pathway
CREB5 involved in several pathways and played different roles in them. We selected most pathways CREB5 participated on our site, such as cGMP-PKG signaling pathway,cAMP signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TNF signaling pathway | CCL20,PIK3R5,CASP10,ATF4,CXCL2,MMP3,PIK3CB,CCL2,MMP9,MAPK8 |
| Dopaminergic synapse | CALML5,PLCB3,MAOB,AKT2,COMT,MAOA,PPP2R2B,DRD5,PRKCA,CALM3 |
| cAMP signaling pathway | MAP2K2,ATP1A3,GRIN2C,PLD1,NPR1,HTR1A,ATP1A4,CALML5,GNAI1,PRKACA |
| Insulin resistance | RPS6KA6,PYGMA,PRKCQ,RPS6KA1,RPS6KB1,RPS6KB1B,MGEA5,TBC1D4,NFKBIA,CREB1A |
| AMPK signaling pathway | AKT1S1,MLYCD,PRKAB1,PPP2R5B,CRTC2,PIK3R5,ADRa1A,RAB10,IRS4,PPP2R5E |
| Cocaine addiction | GRIN2B,MAOB,CDK5,CDK5R1,DRD1A,GRIN2C,GNAI2,CREB3L3,GRIN2A,PRKACG |
| Prostate Cancer | ERBB2,Ar,CCNE1,CREB3L3,INSRR,PDGFB,MDM2,PIK3CD,PIK3CG,CREB3L2 |
| Aldosterone synthesis and secretion | CALM2,PLCB1,CREB3,CALM4,NR4A2,AGTR1B,DDX1,CYP21A2,PRKACA,CACNA1H |
| Thyroid hormone synthesis | PDIA4,GSR,ATP1A3,ATP1A1,CREB3L1,LRP2,TSHB,SLC5A5,GNAQ,ATP1B3 |
Protein Function
CREB5 has several biochemical functions, for example, metal ion binding,protein binding,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB5 itself. We selected most functions CREB5 had, and list some proteins which have the same functions with CREB5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZFP260,KDM5B,PRRXL1,ARNTL2,DBPB,UBN1,STAT4,NFE2L2A,REL,HOXC8 |
| sequence-specific DNA binding | NKX6.2,HLFB,NR4A2A,FOXI1,PPARD,RORB,ZNF165,IRX5B,HMX3,GLI1 |
| metal ion binding | ZNF483,ATP2A2A,CACNA2D2,ZNF526,TRIM50,ZNF750,CYP2X8,PRSS37,ZNF550,ZFP91 |
| protein binding | SCARB2,FAM195A,ZNF18,PFTK1,GLRX3,SH3BP2,MED11,FAM192A,HIST2H3C,TGIF1 |
Interacting Protein
CREB5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB5.
KRTAP5-9;LGALS13
CREB5 Related Signal Pathway
Resources
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References
- Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
