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Official Full Name cAMP responsive element binding protein 5
Background The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family;contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a;heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript;variants encoding different isoforms have been identified.
Synonyms CREB5; cAMP responsive element binding protein 5; cyclic AMP-responsive element-binding protein 5; cAMP response element binding protein CRE Bpa; CRE BPA; H_GS165L15.1; CREB-5; cAMP-responsive element-binding protein 5; cAMP response element binding prote
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CREB5-1112H Recombinant Human CREB5 protein, His & T7-tagged E.coli His/T7
    Human CREB5-1850H Recombinant Human CREB5 Protein, GST-tagged Wheat Germ GST
    Human CREB5-7286HCL Recombinant Human CREB5 293 Cell Lysate HEK293 N/A
    Mouse CREB5-3892M Recombinant Mouse CREB5 Protein Mammalian Cell His

    creb5 involved in several pathways and played different roles in them. We selected most pathways creb5 participated on our site, such as cGMP-PKG signaling pathway, cAMP signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with creb5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    cGMP-PKG signaling pathway ATF4; PPP1CA; SLC25A6; PPP1R12A; PLCB4; ATP2B1; NFATC3; SLC25A4; CREB3L3; PLCB1
    cAMP signaling pathway PLD1; SOX9; HCAR3; RAC2; ATP1B2; PIK3R1; CNGA3; ATP1A3; CNGA2; ATP1B4
    PIK-Akt signaling pathway LAMA3; AKT2; IL2RA; LAMB4; GYS2; IL4; IL7R; ITGB7; ITGA2B; IGF1
    AMPK signaling pathway STK11; PFKL; INS; CAMKK1; PPP2R3A; CCND1; Scd1; HMGCR; ADIPOQ; PDPK1
    Adrenergic signaling in cardiomyocytes CACNB2A; ATF4B1; CAMK2D1; RAPGEF4; PRKACB; MAPK1; CALM3B; VMHCL; GNAI3; CACNA2D3
    TNF signaling pathway MAPK3; MAP3K14; CASP8; FADD; TRAF3; Ccl12; MAPK13; MAP3K5; LIF; TNFRSF1B
    Cholinergic synapse KCNQ2; GNB2; CAMK2A; GNG13; PIK3CD; PIK3R5; PIK3R2; ACHE; ATF4; PLCB1
    Dopaminergic synapse PRKACG; PRKACA; CAMK2D; CREB3L3; GNAI2; PPP2R1B; DRD1; GNGT2; PPP2CB; PPP2R5E
    Insulin secretion GCG; KCNN3; CAMK2D; CREB5; CAMK2G; FFAR1; INS; INS1; KCNMB2; ATP1A2
    Estrogen signaling pathway ITPR3; SP1; HSPA8; CALM1; PIK3CG; ESR2; RAF1; KCNJ6; PLCB3; NOS3
    Thyroid hormone synthesis TSHB; CANX; ATP1A3; TTF2; PLCB1; PLCB2; ITPR1; IYD; PRKACG; PLCB4
    Glucagon signaling pathway PPARA; LDHB; SIK2; PKM; CALML5; PCK1; PPP3R2; GNAQ; PRKAG3; ITPR1
    Aldosterone synthesis and secretion CAMK1G; CALML3; CYP21A1; PLCB2; ADCY8; ORAI1; NR4A1; ITPR1; CAMK2A; CYP11A1
    Insulin resistance PYGB; TNFRSF1A; GFPT2; AKT1; PPARA; PRKCBA; SLC27A5; PRKAG3; PPP1R3CB; PIK3R2
    Vasopressin-regulated water reabsorption AVPR2; ARHGDIG; CREB5; DYNC2LI1; AQP4; GNAS; CREB3L2; DCTN5; AQP2; AQP3
    Huntingtons disease HAP1; NDUFA5; HTT; NDUFA4L2; PLCB2; COX6B1; NDUFA7; COX6C; CREB5; NDUFV1
    Cocaine addiction GRIN3B; CREB3; GRM3; CREB5; PRKACB; BDNF; ATF6B; PRKACG; SLC18A1; CREB3L3
    Amphetamine addiction GNAS; PRKACB; GRIA1; MAOB; CAMK2G; CAMK4; HDAC1; CREB3L1; PPP3R2; GRIN1
    Hepatitis B DDX58; PIK3R3; NFKB1; TBK1; YWHAB; Ifna11; PIK3R5; IFNA13; ELK1; IL-8
    Viral carcinogenesis RBPJL; CCNA1; HIST1H4I; HDAC7A; RAC1; TRAF3; UBE3A; CREB5; HIST1H2BB; HIST1H2BO
    Prostate cancer PTEN; CREB3L2; AKT2; ERBB2; TCF7L2; ARID1A; FOXO1; PIK3CB; GSTP1; FGFR1

    creb5 has several biochemical functions, for example, metal ion binding, protein binding, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by creb5 itself. We selected most functions creb5 had, and list some proteins which have the same functions with creb5. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding GALNS; CNOT8; PGCP; ANG3; PRMT3; HAND2; FTR67; DNAJA2; FHL2B; GUCY1B3
    protein binding AMBP; JAG2; ATXN2; MAPK11; IKZF1; CD22; RNF11; TSGA10IP; RIPPLY1; TBPL1
    sequence-specific DNA binding RORCA; ASCL1A; KDM6B; IRX6A; HOXD11; ESRRB; SCAND2P; HOXA1; HLF; NKX6.2
    transcription factor activity, sequence-specific DNA binding NR2F6; ARNT; ZNF643; ZSCAN16; E2F5; VAX2; ZNF792; THRAA; CBFA2T3; ZFP629

    creb5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with creb5 here. Most of them are supplied by our site. Hope this information will be useful for your research of creb5.

    KRTAP5-9; LGALS13

    Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
    Erion, DM; Kotas, ME; et al. cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 2 (CRTC2) Promotes Glucagon Clearance and Hepatic Amino Acid Catabolism to Regulate Glucose Homeostasis. JOURNAL OF BIOLOGICAL CHEMISTRY 288:16167-16176(2013).

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