Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

DCX

  • Official Full Name

    doublecortin

  • Overview

    This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
  • Synonyms

    DCX; doublecortin; DC; DBCN; LISX; SCLH; XLIS; neuronal migration protein doublecortin; lis-X; doublin; doublecortex; lissencephalin-X;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCX-543H Recombinant Human DCX protein(Ala45-Val150), GST-tagged E. coli N-GST Ala45-Val150
Human DCX-26890TH Recombinant Human DCX, His-tagged E.coli His
Human DCX-2423H Recombinant Human DCX Protein, GST-tagged Wheat Germ GST
Human DCX-7032HCL Recombinant Human DCX 293 Cell Lysate HEK293 N/A
Human DCX-7031HCL Recombinant Human DCX 293 Cell Lysate HEK293 N/A
Human DCX-421H Recombinant Human DCX Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human DCX-5885H Recombinant Human DCX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DCX-2807H Recombinant Human DCX protein, His-SUMO-tagged E.coli His-SUMO 1-441aa
Human DCX-3626H Recombinant Human DCX Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DCX-2419HF Recombinant Full Length Human DCX Protein, GST-tagged In Vitro Cell Free System GST 360 amino acids
Mouse DCX-4376M Recombinant Mouse DCX Protein Mammalian Cell His
Mouse DCX-2248M-B Recombinant Mouse DCX Protein Pre-coupled Magnetic Beads HEK293
Mouse Dcx-681M Recombinant Mouse Dcx Protein, His-tagged E.coli His Met1~Met366
Mouse DCX-2248M Recombinant Mouse DCX Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dcx-2487M Recombinant Mouse Dcx Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken DCX-5907C Recombinant Chicken DCX Mammalian Cell His
Chicken DCX-5294C Recombinant Chicken DCX protein, His-tagged E.coli His 1-361aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DCX Related Articles

DCX involved in several pathways and played different roles in them. We selected most pathways DCX participated on our site, such as Axon guidance, Developmental Biology, L1CAM interactions, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCX were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceTRPC4;COL4A4;CREB1B;EPHA8;PPP3CA;DPYSL5A;EPHB4A;SEMA5B;FGFR1B
Developmental BiologyDUSP7;NR6A1;DRAP1;EFNA1;RHOGA;ARHGEF28;SPTA1;GPC1A;SDCBP
L1CAM interactionsCNTN6;SDCBP;NRP2;SCN2B;DCX;EZRA;DPYSL2;KCNQ3;SCN9A
Lissencephaly gene (LIS1) in neuronal migration and developmentMAP1B;DAB1;NUDC;KATNA1;DCX;VLDLR;LRPAP1;DYNLT1;NDEL1
Neurofascin interactionsDCX;CNTN1;SDCBP

DCX has several biochemical functions, for example, calcium-dependent protein serine/threonine kinase activity, calmodulin binding, calmodulin-dependent protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DCX itself. We selected most functions DCX had, and list some proteins which have the same functions with DCX. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent protein serine/threonine kinase activityMKNK2A;MAPKAPK2B;MAPKAPK5;CAMK1GB;MKNK1;MAPKAPK2A;MKNK2;CAMK1GA;CAMK4
calmodulin bindingKCNN2;ATPIF1;IQCB1;ENKUR;SLC8A2;MYH1;ADD1;MYLK;SRY
calmodulin-dependent protein kinase activityMKNK2B;SLC14A2;MAPKAPK2A;CAMK4;CAMK1G;CAMK1D;CAMK1;CAMK2D2;CAMK2A
microtubule bindingMACF1;DPYSL5A;PAFAH1B1B;CAMSAP1A;NEFM;MAP2;CAMSAP1B;LC3;KIF13B
protein bindingCSE1L;SLAMF6;ATF5;HTN1;PIP5K1C;PEF1;TSPAN6;PRTFDC1;DAZAP2
protein kinase bindingFAF1;B4GALT1;CACNB3;PTPRR;ELP2;PAK2;MAVS;MAPK4;Cd24a

DCX has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCX here. Most of them are supplied by our site. Hope this information will be useful for your research of DCX.

GOLGA2; IKZF1; ZBTB5; TRIM27; TRIM23; MEOX1

Stanton, GB; Kohler, SJ; et al. Cytogenesis in the Adult Monkey Motor Cortex: Perivascular NG2 Cells Are the Major Adult Born Cell Type. JOURNAL OF COMPARATIVE NEUROLOGY 523:849-868(2015).
Lovelace, MD; Gu, BJ; et al. P2X7 Receptors Mediate Innate Phagocytosis by Human Neural Precursor Cells and Neuroblasts. STEM CELLS 33:526-541(2015).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (3)

Write a review
Reviews
03/14/2020

    This guarantees the reliability and reproducibility of research findings and eliminates potential issues arising from impurities or contamination.

    02/27/2020

      Reputable manufacturers often provide technical support to researchers using DCX protein.

      04/15/2016

        Manufacturers can ensure high-quality production of DCX protein, maintaining its purity and integrity.

        Ask a Question for All DCX Products

        Required fields are marked with *

        My Review for All DCX Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends