DDB2

Official Full Name

damage-specific DNA binding protein 2, 48kDa
Overview

This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]
Synonyms

DDB2; damage-specific DNA binding protein 2, 48kDa; DDBB; UV-DDB2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DDB2-28309TH	Recombinant Human DDB2 Protein, His-tagged	E.coli	His	1-261 aa	Inquiry
Human	DDB2-05TH	Recombinant Human DDB2 Protein, GST-tagged	Wheat Germ	GST	1 a.a. - 427 a.a.	Inquiry
Human	DDB2-057H	Recombinant Human DDB2 Protein, GST-tagged	Wheat Germ	GST	1-427	Inquiry
Human	DDB2-452H	Recombinant Human DDB2 Protein, His-tagged	E.coli	His	Pro166~Met383	Inquiry
Human	DDB2-7029HCL	Recombinant Human DDB2 293 Cell Lysate	HEK293	Non		Inquiry
Human	DDB2-1549HF	Recombinant Full Length Human DDB2 Protein, GST-tagged	In Vitro Cell Free System	GST	427 amino acids	Inquiry
Human	DDB2-1933H	Recombinant Human DDB2 Protein (Pro166-Met383), His tagged	E.coli	His	Pro166-Met383	Inquiry
Human	DDB2-1564HF	Recombinant Full Length Human DDB2 Protein, GST-tagged	In Vitro Cell Free System	GST	427 amino acids	Inquiry
Human	DDB2-6874H	Recombinant Human DDB2 protein, His-tagged	E.coli	His	1-427aa	Inquiry
Mouse	Ddb2-453H	Recombinant Mouse Ddb2 Protein, His-tagged	E.coli	His	Lys212~Leu407	Inquiry
Rhesus Macaque	DDB2-1204R	Recombinant Rhesus monkey DDB2 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DDB2-1029R	Recombinant Rhesus Macaque DDB2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	DDB2-1029R-B	Recombinant Rhesus Macaque DDB2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	DDB2-5371Z	Recombinant Zebrafish DDB2	Mammalian Cell	His		Inquiry
Chicken	DDB2-3361C	Recombinant Chicken DDB2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

DDB2 involved in several pathways and played different roles in them. We selected most pathways DDB2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Damage Recognition in GG-NER	DDB1;COPS7A;COPS7B;COPS8;CETN2;PARP1;INO80;YY1;COPS2
DNA Repair	TDP1;COPS2;COPS3;TOPBP1;DDB2;RAD9;CETN2;CHEK1;COPS4
DNA damage response	RAD1;RAD9A;RAD17;GADD45A;GADD45G;CHEK2;DDB2;CDK5;TLK2
Direct p53 effectors	PCBP4;FDXR;BNIP3L;CD82;ARID3A;CCNK;TRIAP1;DDB2;TADA2B
Dual Incision in GG-NER	DDB2;CHD1L;PARP2;DDB1
Formation of Incision Complex in GG-NER	PIAS3;USP45;CETN2;DDB1;CHD1L;RNF111;DDB2;PARP2
Global Genome Nucleotide Excision Repair (GG-NER)	COPS8;INO80E;COPS4;COPS3;PARP2;YY1A;INO80B;YY1;INO80C
Hepatitis B	MAP2K1;MAPK1;NFATC4;STAT5A;MAPK8;TGFB3;RAF1;IRF3;IFNA6

DDB2 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB2 itself. We selected most functions DDB2 had, and list some proteins which have the same functions with DDB2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	FOXI3B;TIGD3;AKAP8L;NFIL3;HOXA2B;HOXD3;HOXB5B;ENG1A;HIST3H2A
contributes_to damaged DNA binding	NBN;CUL4B;DDB2;DDB1
protein binding	PRR13;MAP2K5;BTN3A1;NFKBIB;CNNM3;NSMCE2;DAP3;MMP15;UPF3B
contributes_to ubiquitin-protein transferase activity	KLHL24B;KLHL40A;KLHL29;FBXW8;KLHL33;KCTD10;KLHL12;KLHL9;TCEB3B

DDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB2.

DDB1; COPS5; CUL4A; Ddb1; DDA1; E2F1; CUL4B; COPS6; GPS1