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Official Full Name damage-specific DNA binding protein 2, 48kDa
Background This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]
Synonyms DDB2; damage-specific DNA binding protein 2, 48kDa; DDBB; UV-DDB2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDB2-057H Recombinant Human DDB2 Protein, GST-tagged Wheat Germ GST
    Human DDB2-05TH Recombinant Human DDB2 Protein, GST-tagged Wheat Germ GST
    Human DDB2-28309TH Recombinant Human DDB2 Protein, His-tagged E.coli His
    Human DDB2-452H Recombinant Human DDB2 Protein, His-tagged E.coli His
    Human DDB2-7029HCL Recombinant Human DDB2 293 Cell Lysate HEK293 N/A
    Mouse Ddb2-453H Recombinant Mouse Ddb2 Protein, His-tagged E.coli His
    Rhesus Macaque DDB2-1204R Recombinant Rhesus monkey DDB2 Protein, His-tagged Mammalian Cell His
    Chicken DDB2-3361C Recombinant Chicken DDB2 Mammalian Cell His
    Zebrafish DDB2-5371Z Recombinant Zebrafish DDB2 Mammalian Cell His

    ddb2 involved in several pathways and played different roles in them. We selected most pathways ddb2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with ddb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    DNA Damage Recognition in GG-NER GPS1; TFPT; ACTR5; NFRKB; CETN2; PARP2; COPS5; COPS8; INO80; PARP1
    DNA Repair FAM175A; ASCC3; RAD9B; RNF111; INO80; PPP4R2; CHEK1; CLSPN; FUZ; BARD1
    DNA damage response HUS1B; CHEK2; RAD17; RAD9A; RAD1; TLK2; CDK5; GADD45G; GADD45A; DDB2
    Direct p53 effectors CSE1L; RNF144B; PPM1J; DDB2; EPHA2; FDXR; AIFM2; CEBPZ; SCN3B; BNIP3L
    Dual Incision in GG-NER PARP2; DDB2; CHD1L; DDB1
    Formation of Incision Complex in GG-NER PARP2; DDB2; CETN2; RNF111; PIAS3; CHD1L; DDB1; USP45
    Global Genome Nucleotide Excision Repair (GG-NER) COPS7A; INO80C; INO80B; YY1; COPS3; COPS7B; DDB2; INO80E; NFRKB; MCRS1
    Hepatitis B MAPK3; Casp3; YWHAB; RB1; IL6; NFATC1; NFKBIA; ELK1; BAX; RELA

    ddb2 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ddb2 itself. We selected most functions ddb2 had, and list some proteins which have the same functions with ddb2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding OTX1A; NKX6.3; EXO1; SNAPC1; ZNF224; ZNF689; ZNF705B; RORAA; LEF1; NR2F5
    contributes_to damaged DNA binding DDB1; CUL4B; NBN; DDB2
    protein binding RUFY4; TICAM1; CERK; EMD; SEPT4; CD300A; WSB1; KRT6C; PIN4; PHIP
    contributes_to ubiquitin-protein transferase activity FBXL3; KLHL7; KLHL26; KBTBD5; RNF20; KLHL28; KEAP1; KLHL22; BACH2; KBTBD6

    ddb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddb2.

    DDB1; COPS5; CUL4A; Ddb1; DDA1; E2F1; CUL4B; COPS6; GPS1

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