DDB2

  • Official Full Name

    damage-specific DNA binding protein 2, 48kDa

  • Overview

    This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]
  • Synonyms

    DDB2; damage-specific DNA binding protein 2, 48kDa; DDBB; UV-DDB2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DDB2-28309TH Recombinant Human DDB2 Protein, His-tagged E.coli His 1-261 aa
Human DDB2-05TH Recombinant Human DDB2 Protein, GST-tagged Wheat Germ GST 1 a.a. - 427 a.a.
Human DDB2-057H Recombinant Human DDB2 Protein, GST-tagged Wheat Germ GST
Human DDB2-452H Recombinant Human DDB2 Protein, His-tagged E.coli His Pro166~Met383
Human DDB2-7029HCL Recombinant Human DDB2 293 Cell Lysate HEK293 N/A
Human DDB2-1549HF Recombinant Full Length Human DDB2 Protein, GST-tagged In Vitro Cell Free System GST 427 amino acids
Human DDB2-1933H Recombinant Human DDB2 Protein (Pro166-Met383), His tagged E.coli His Pro166-Met383
Human DDB2-1564HF Recombinant Full Length Human DDB2 Protein, GST-tagged In Vitro Cell Free System GST 427 amino acids
Human DDB2-6874H Recombinant Human DDB2 protein, His-tagged E.coli N-His 1-427aa
Mouse Ddb2-453H Recombinant Mouse Ddb2 Protein, His-tagged E.coli His Lys212~Leu407
Rhesus Macaque DDB2-1204R Recombinant Rhesus monkey DDB2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DDB2-1029R Recombinant Rhesus Macaque DDB2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque DDB2-1029R-B Recombinant Rhesus Macaque DDB2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish DDB2-5371Z Recombinant Zebrafish DDB2 Mammalian Cell His
Chicken DDB2-3361C Recombinant Chicken DDB2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

DDB2 involved in several pathways and played different roles in them. We selected most pathways DDB2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DNA Damage Recognition in GG-NERCOPS4;ACTR5;MCRS1;GPS1;NFRKB;INO80B;COPS6;COPS7A;CETN2
DNA RepairUBE2L6;ELL;RAD17;TIPIN;PIAS3;ZFP830;RAD1;UIMC1;COPS7B
DNA damage responseGADD45A;HUS1B;TLK2;RAD17;DDB2;CDK5;RAD1;CHEK2;RAD9A
Direct p53 effectorsAIFM2;TADA2B;DDX5;EDN2;BNIP3L;DUSP5;PLK3;GDF15;ARID3A
Dual Incision in GG-NERDDB2;PARP2;DDB1;CHD1L
Formation of Incision Complex in GG-NERUSP45;CHD1L;PARP2;CETN2;PIAS3;DDB2;RNF111;DDB1
Global Genome Nucleotide Excision Repair (GG-NER)MCRS1;COPS5;COPS4;COPS2;NFRKB;CHD1L;COPS6;YY1A;INO80C
Hepatitis BSTAT1;FAS;DDX3X;CASP9;VDAC3;CCNA2;TNF;CCND1;MAP2K1

DDB2 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDB2 itself. We selected most functions DDB2 had, and list some proteins which have the same functions with DDB2. You can find most of the proteins on our site.

Function Related Protein
DNA bindingPQBP1;ZFP579;PAPD7;PPARAB;ZFP423;NKX2-3;PTGES2;TRIM26;ZNF483
contributes_to damaged DNA bindingNBN;CUL4B;DDB2;DDB1
protein bindingDACT1;MERTK;PRKCD;LCOR;CTSB;HELZ2;THBS1;RAD9;ARHGEF10
contributes_to ubiquitin-protein transferase activityBCOR;BTRC;KLHL42;KLHL29;BACH2;KLHL40A;KLHL4;KLHL7;KLHL32

DDB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDB2.

DDB1; COPS5; CUL4A; Ddb1; DDA1; E2F1; CUL4B; COPS6; GPS1

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