|Official Full Name||damage-specific DNA binding protein 2, 48kDa|
|Background||This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]|
|Synonyms||DDB2; damage-specific DNA binding protein 2, 48kDa; DDBB; UV-DDB2; DNA damage-binding protein 2; UV-DDB 2; DDB p48 subunit; UV-damaged DNA-binding protein 2; damage-specific DNA-binding protein 2; xeroderma pigmentosum group E protein;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ddb2 involved in several pathways and played different roles in them. We selected most pathways ddb2 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, DNA damage response, which may be useful for your reference. Also, other proteins which involved in the same pathway with ddb2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|DNA Damage Recognition in GG-NER||GPS1; TFPT; ACTR5; NFRKB; CETN2; PARP2; COPS5; COPS8; INO80; PARP1|
|DNA Repair||FAM175A; ASCC3; RAD9B; RNF111; INO80; PPP4R2; CHEK1; CLSPN; FUZ; BARD1|
|DNA damage response||HUS1B; CHEK2; RAD17; RAD9A; RAD1; TLK2; CDK5; GADD45G; GADD45A; DDB2|
|Direct p53 effectors||CSE1L; RNF144B; PPM1J; DDB2; EPHA2; FDXR; AIFM2; CEBPZ; SCN3B; BNIP3L|
|Dual Incision in GG-NER||PARP2; DDB2; CHD1L; DDB1|
|Formation of Incision Complex in GG-NER||PARP2; DDB2; CETN2; RNF111; PIAS3; CHD1L; DDB1; USP45|
|Global Genome Nucleotide Excision Repair (GG-NER)||COPS7A; INO80C; INO80B; YY1; COPS3; COPS7B; DDB2; INO80E; NFRKB; MCRS1|
|Hepatitis B||MAPK3; Casp3; YWHAB; RB1; IL6; NFATC1; NFKBIA; ELK1; BAX; RELA|
ddb2 has several biochemical functions, for example, DNA binding, contributes_to damaged DNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ddb2 itself. We selected most functions ddb2 had, and list some proteins which have the same functions with ddb2. You can find most of the proteins on our site.
|DNA binding||OTX1A; NKX6.3; EXO1; SNAPC1; ZNF224; ZNF689; ZNF705B; RORAA; LEF1; NR2F5|
|contributes_to damaged DNA binding||DDB1; CUL4B; NBN; DDB2|
|protein binding||RUFY4; TICAM1; CERK; EMD; SEPT4; CD300A; WSB1; KRT6C; PIN4; PHIP|
|contributes_to ubiquitin-protein transferase activity||FBXL3; KLHL7; KLHL26; KBTBD5; RNF20; KLHL28; KEAP1; KLHL22; BACH2; KBTBD6|
ddb2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddb2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddb2.
DDB1; COPS5; CUL4A; Ddb1; DDA1; E2F1; CUL4B; COPS6; GPS1