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FGD4

Official Full Name

FYVE, RhoGEF and PH domain containing 4
Overview

This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.
Synonyms

FGD4; FYVE, RhoGEF and PH domain containing 4; FGD1 family, member 4; FYVE, RhoGEF and PH domain-containing protein 4; CMT4H; frabin; FRABP; ZFYVE6; FGD1-related F-actin-binding protein; actin-filament binding protein frabin; zinc finger FYVE domain-conta;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	FGD4-6253HCL	Recombinant Human FGD4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	FGD4-4092H	Recombinant Human FGD4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	FGD4-4805HF	Recombinant Full Length Human FGD4 Protein, GST-tagged	In Vitro Cell Free System	GST	766 amino acids	Inquiry
Human	FGD4-2306H	Recombinant Human FGD4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Mouse	FGD4-5834M	Recombinant Mouse FGD4 Protein	Mammalian Cell	His		Inquiry
Mouse	Fgd4-2992M	Recombinant Mouse Fgd4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Mouse	FGD4-3222M	Recombinant Mouse FGD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	FGD4-3222M-B	Recombinant Mouse FGD4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	FGD4-2322R	Recombinant Rat FGD4 Protein	Mammalian Cell	His		Inquiry
Rat	FGD4-1979R	Recombinant Rat FGD4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	FGD4-1979R-B	Recombinant Rat FGD4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
FGD4 Related Articles

FGD4 involved in several pathways and played different roles in them. We selected most pathways FGD4 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with FGD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE	ARHGAP4A;ECT2;BCL2L11;ARHGEF1A;AATF;ARHGEF18;DCLRE1B;TRIO;ARHGEF18A
G alpha (12/13) signalling events	FGD4;GNA13B;ECT2;RHOGA;ARHGEF16;ARHGEF18;ARHGAP4;TRIO;RHOB
GPCR downstream signaling	TAC1;ADORA1;ADM2A;MCF2L;RXFP2B;ADRB3;RHOGA;DGKA;TAS2R16
NRAGE signals death through JNK	ARHGEF16;AKAP13;DCLRE1B;ARHGEF17;ARHGAP4A;ABR;PLEKHG2;ECT2;FGD4A
Rho GTPase cycle	ARHGAP24;PLEKHG2;CHN1;ARHGAP31;ARHGAP19;ARHGAP17;ARHGAP4A;ARHGAP25;ARHGAP29
Signal Transduction	HECW1B;PTGDR2;LIN7B;FAM13B;CCL35.1;METAP2;PTPRK;GRAP;GPRC6A
Signaling by GPCR	OXGR1A.2;TAS2R13;CALCB;NMBA;GPR132B;ANXA1C;GPBAR1;S1PR5B;PENKB
Signaling by Rho GTPases	RHOT1B;FAM13B1;NCKIPSD;ARHGAP4A;ARAP2;CHN2;MKL1B;ARHGAP22;IQGAP3

FGD4 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, actin binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FGD4 itself. We selected most functions FGD4 had, and list some proteins which have the same functions with FGD4. You can find most of the proteins on our site.

Function	Related Protein
Rho guanyl-nucleotide exchange factor activity	ARHGEF9;C3A.1;VAV2;ARHGEF2;PLEKHG6;FGD2;RASGRF2B;ARHGEF17;PLEKHG7
actin binding	FHL3;PARK2;WASB;KCNMA1;PLEKHH2;SPTB;MYH8;WASLB;MYBPC2
guanyl-nucleotide exchange factor activity	RALGPS2;RAPGEF4;PLCE1;DIS3;RASGRP2;RASGEF1BA;RIC8A;ARFGEF2;CHRM4
metal ion binding	PELO;AOX4;MOB3A;OAS1;ADAL;Car4;ZNF445;ZFP516;HPD
small GTPase binding	ABCA1;FGD3;FGD4;FGD1;TSC2;RCC2;GDI2;FGD6;RNF152

FGD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FGD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of FGD4.

pi3p

Noseda, R; Belin, S; et al. DDIT4/REDD1/RTP801 Is a Novel Negative Regulator of Schwann Cell Myelination. JOURNAL OF NEUROSCIENCE 33:15295-15305(2013).

Arai, H; Hayashi, M; et al. The first Japanese case of Charcot Marie Tooth disease type 4H with a novel FGD4 c.837-1G > A mutation. NEUROMUSCULAR DISORDERS 23:652-655(2013).