| Description : |
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
86.4 kDa |
| AA Sequence : |
MEEIKPASASCVSKEKPSKVSDLIS RFEGGSSLSNYSDLKKESAVNLNAP RTPGRHGLTTTPQQKLLSQHLPQRQ GNDTDKTQGAQTCVANGVMAAQNQM ECEEEKAATLSSDTSIQASEPLLDM HIVNGERDETATAPASPTTDSCDGN ASDSSYRTPGIGPVLPLEERGAETE TKVQERENGESPLELEQLDQHHEMK ETNEQKLHKIANELLLTERAYVNRL DLLDQVFYCKLLEEANRGSFPAEMV NKIFSNISSINAFHSKFLLPELEKR MQEWETTPRIGDILQKLAPFLKMYG EYVKGFDNAMELVKNMTERIPQFKS VVEEIQKQKICGSLTLQHHMLEPVQ RIPRYEMLLKDYLRKLPPDSLDWND AKKSLEIISTAASHSNSAIRKMENL KKLLEIYEMLGEEEDIVNPSNELIK EGQILKLAARNTSAQERYLFLFNNM LLYCVPKFSLVGSKFTVRTRVGIDG MKIVETQNEEYPHTFQVSGKERTLE LQASSAQDKEEWIKALQETIDAFHQ RHETFRNAIAKDNDIHSEVSTAELG KRAPRWIRDNEVTMCMKCKEPFNAL TRRRHHCRACGYVVCWKCSDYKAQL EYDGGKLSKVCKDCYQIISGFTDSE EKKRKGILEIESAEVSGNSVVCSFL QYMEKSKPWQKAWCVIPKQDPLVLY MYGAPQDVRAQATIPLLGYVVDEMP RSADLPHSFKLTQSKSVHSFAADSE ELKQKWLKVILLAVTGETPGGPNEH PATLDDHPEPKKKSECTRTRPLEQK LISEEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
