FRS2

  • Official Full Name

    fibroblast growth factor receptor substrate 2

  • Overview

    Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene.
  • Synonyms

    FRS2; fibroblast growth factor receptor substrate 2; FRS2A; FRS2alpha; SNT 1; SNT1; FGFR signaling adaptor SNT; FGFR signalling adaptor; FGFR substrate 2; FGFR-signaling adaptor SNT; FRS 2; FRS2_HUMAN; SNT; SNT-1; Suc 1 Associated Neurotrophic Factor Target; Suc1 associated neurotrophic factor target 1; Suc1-associated neurotrophic factor target 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human FRS2-28951TH Recombinant Human FRS2 Wheat Germ N/A 341 amino acids
Human FRS2-23H Recombinant Human FRS2 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human FRS2-22H Recombinant Human FRS2 protein, His-tagged E.coli His
Human FRS2-6134HCL Recombinant Human FRS2 293 Cell Lysate HEK293 N/A
Human FRS2-4506H Recombinant Human FRS2 Protein, GST-tagged Wheat Germ GST
Human FRS2-2677H Recombinant Human FRS2 Protein (Asp239-Asn449), His tagged E.coli His Asp239-Asn449
Human FRS2-3641H Recombinant Human FRS2 protein, GST-tagged E.coli GST 1-300 aa
Human FRS2-3091H Recombinant Human FRS2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human FRS2-3203H Recombinant Human FRS2 protein, His-tagged E.coli His 1-300 aa
Human FRS2-5068HF Recombinant Full Length Human FRS2 Protein, GST-tagged In Vitro Cell Free System GST 512 amino acids
Mouse FRS2-6048M Recombinant Mouse FRS2 Protein Mammalian Cell His
Mouse Frs2-3087M Recombinant Mouse Frs2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse FRS2-3367M Recombinant Mouse FRS2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse FRS2-3367M-B Recombinant Mouse FRS2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Frs2-191M Recombinant Mouse Frs2 Protein, His-tagged E.coli His Leu268~Pro453
Rat Frs2-192R Recombinant Rat Frs2 Protein, His-tagged E.coli His Leu268~Pro453
Chicken FRS2-4430C Recombinant Chicken FRS2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • FRS2 Related Signal Pathway

FRS2 involved in several pathways and played different roles in them. We selected most pathways FRS2 participated on our site, such as ARMS-mediated activation, Adaptive Immune System, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with FRS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ARMS-mediated activationCSF2RA;FGFR1B;JAK3;NTF7;DLG4;SPTA1;SPNA1;NETO2;JAK2
Adaptive Immune SystemFGFR1B;CLEC2D;UBR2;OSCAR;RNF144B;CD300LH;ERAP2;UBE2U;DZIP3
Axon guidanceARPC4;SRGAP1;PAK7;AP2M1;SLIT2;PPP3R2;L1CAM;GDNF;PHB
BDNF signaling pathwayCSNK2A1;GNB2L1;EGR1;CDH2;CDK5;EEF2;IGF2BP1;JAK2;FRS2
Constitutive Signaling by Aberrant PI3K in CancerNRG4;FRS2;NRG3;EGF;TRAT1;HBEGF;KLB
Cytokine Signaling in Immune systemEIF4G2A;GBP6;PRLRB;WDR83;TRIM38;IFI30;UBE2V1;PTPRA;FRS2
DAP12 interactionsDUSP1;NRG4;PEBP1;LAMTOR2;TREM1;PRKAR1AA;KIR2DS2;DUSP7;FGF20A
DAP12 signalingKBTBD7;SPRED2;SPRED3;CNKSR1;HBEGF;DUSP2;FRS2A;RASGRP1;SPNA1

FRS2 has several biochemical functions, for example, fibroblast growth factor receptor binding, insulin receptor binding, neurotrophin TRKA receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FRS2 itself. We selected most functions FRS2 had, and list some proteins which have the same functions with FRS2. You can find most of the proteins on our site.

Function Related Protein
fibroblast growth factor receptor bindingFGF16;FGF1A;FGF4;FGF6A;FGF10B;FGF22;FGF20B;FGF6B;FGF10
insulin receptor bindingIGF1;FRS2A;FRS3;DOK6;IRS1;DOK1;SLC2A2;SNX1;PIK3R1
neurotrophin TRKA receptor bindingPLCG1;EFNA5;NGFR;GRB2;FRS2;SHC1;PIK3R1
phosphatase activator activityBMP2;GTF2F1;FRS2
protein bindingLIG4;LINC00482;G0S2;TRAF7;MLANA;DRD2;ITGB3;PLK3;PTPN22
transmembrane receptor protein tyrosine kinase adaptor activitySTAP1;BLNK;DOK2;GAB2;FRS2;TRAT1;SHC1;SH2B2;PIK3R1

FRS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FRS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of FRS2.

PTPN11; RPS6; BECN1; suc1; FGFR1; GRB2; SH2B1; Coro1c

Gene Family

TGF

Research Area

Related articles

Issa, A; Gill, JW; et al. Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models. BREAST CANCER RESEARCH 15:-(2013).
Hisaoka, K; Tsuchioka, M; et al. Tricyclic Antidepressant Amitriptyline Activates Fibroblast Growth Factor Receptor Signaling in Glial Cells INVOLVEMENT IN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR PRODUCTION. JOURNAL OF BIOLOGICAL CHEMISTRY 286:21118-21128(2011).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
12/28/2021

    The catalytic activity of FRS2 is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.

    08/31/2021

      Stability of FRS2 is very high, and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.

      02/03/2019

        The production process of FRS2 uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, bringing a positive impact on the environment.

        Q&As (6)

        Ask a question
        What is the role of FRS2 protein in the pathogenesis of insulin resistance? 10/27/2022

        FRS2 protein regulates signal transduction of insulin receptors, so its abnormal expression or function can lead to the pathogenesis of insulin resistance.

        How is FRS2 involved in hepatocyte differentiation and carcinogenesis? 12/05/2021

        FRS2 plays an important role in the proliferation and differentiation of hepatocytes, and no good regulation will lead to hepatocyte transformation and carcinogenesis.

        What is the potential role of FRS2 protein in cancer treatment? 12/26/2020

        FRS2 protein can be considered a potential target for the treatment of certain types of cancer, so drug research is expected to further explore this effect.

        How does FRS2 protein regulate bone metabolism? 07/07/2020

        The bone metabolism regulated by FRS2 protein is related to bone formation and bone resorption, and plays a role by affecting the signaling and function of bone cells.

        How does FRS2 protein regulate signal transduction of insulin receptors? 01/03/2020

        The protein can affect insulin metabolism by binding to insulin receptors and other proteins to regulate downstream signaling of insulin receptors.

        What are the conditions caused by defects in FRS2 protein? 02/09/2019

        Defects in the FRS2 protein can lead to the development of pathopathologies such as insulin resistance, obesity, bone metabolism disorders, and neurodegenerative diseases.

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