GATA1
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Official Full Name
GATA binding protein 1 (globin transcription factor 1)
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Background
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008] -
Synonyms
GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
- Involved Pathway
- Protein Function
- Interacting Protein
- GATA1 Related Articles
GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| C-MYB transcription factor network | CDK6;YEATS4;MYOD1;CREBBP;GATA1;PTCRA;CBX4;CEBPA;ADA |
| Factors involved in megakaryocyte development and platelet production | SH2B3;GATA2A;KIF9;CABLES2;ITPK1;BA2;AKAP1;KIF3C;MFN2 |
| Hemostasis | GATA1;ZFPM2A;SERPINA1L;DOCK9;NFE2;F11R.2;F3B;MAFF;PIK3R6 |
| IL-3 Signaling Pathway | GATA1A;GATA2A;GATA1;BIRC5A;SPI1B;KCNIP3;GATA2;KCNIP3B;GSK3AB |
| Notch-mediated HES/HEY network | MYB;YY1;MYOD1;TLE1;RCAN1;HEY1;ASCL1;BGLAP;CTBP1 |
| Signaling events mediated by HDAC Class I | SIRT4;SIRT7;WDR77;TFCP2;PRMT5;FKBP3;SIRT2;GATA2;NR2C1 |
| Signaling events mediated by HDAC Class II | ANKRA2;BCOR;GATA1 |
GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C2H2 zinc finger domain binding | EHMT2;TAF9;GATA1;GATA2;ZXDC;EHMT1;WT1;EBF1;THAP7 |
| DNA binding | HOXA2B;TIGD1;MIER1A;MBD3A;RABGAP1;SETBP1;FOXF2A;RFXANK;OTUD7B |
| DNA binding, bending | GATA1;SRY;HHEX;FOXC1;TOP2B;LEF1;FOXL1;TFAM;FOXI1 |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | POU1F1;SMAD6;GLI2;ZNF713;HAND1;SNAI3;CEBPZ;PHOX2B;EHF |
| RNA polymerase II core promoter sequence-specific DNA binding | MAZ;ZNF335;PAX8;SMYD3;SMAD1;SP3;NFIL3;STAT5A;HNF4A |
| RNA polymerase II regulatory region sequence-specific DNA binding | SOHLH1;ALX1;SUV39H1;ZNF773;NFKB1;POU3F4;ATF1;MYOG;ETV7 |
| RNA polymerase II transcription factor binding | ANKRD1;PITX2;TEAD3;CREBBP;KLF4;GSK3B;GATA1A;ZFPM2;TBX3 |
| chromatin DNA binding | PRDM14;WBP2;BCL6;GATA1;RELA;FOXO3;RXRA;HIST1H1B;NEUROG3 |
| core promoter binding | HDAC1;CALCOCO1;FOXP3;SPI1;CLOCK;PYDC3;MYOG;SFPQ;HDAC2 |
| enhancer sequence-specific DNA binding | KLF6A;LMO4;TWIST1B;TBX19;HMGB2;XBP1;SOX9;GATA2;MYT1 |
| p53 binding | BRD7;MAPKAPK5;CREBBP;PLK3;RNF34;ZFP385C;PSME3;NTRK3;TP53BP1 |
| protein binding | VCL;LPAR2;OPA1;SCG5;DPH2;FGF12;NDUFS3;TLR3;SH3GLB2 |
| sequence-specific DNA binding | SNAI2;ESRRB;POU3F3;POU4F1;VENTX;PRDM16;MAFF;MAFBA;NR2F2 |
| transcription factor activity, sequence-specific DNA binding | ARNT2;GPBP1L1;RUNX1;FOXD1;GRHL2A;BACH1;ZNF83;ZNF334;SRF |
| transcription regulatory region sequence-specific DNA binding | TFAP2A;NR5A5;NFE2L1A;FOXN1;PER2;EGR1;MKL1;GATA1;TBX18 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | TXK;ALS2CR8;ZIC1;TCF4;GATA3;FLI1;DLX5;CEBPE;PGR |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | CEBPA;BHLHA15;STAG1;FOXO3;CREB3L4;GATA1;REST;NKX2;PAX9 |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | MYPOP;NKX3-2;NFATC4;AEBP2;HHEX;BCL11A;ESRRA;TBX15;POU4F2 |
| zinc ion binding | ADAT3;LMO3;ZNRF3;RNF114;NPSN;DBF4B;UNKL;TRIM3B;LMO4A |
GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.
FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL
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