GATA1

  • Official Full Name

    GATA binding protein 1 (globin transcription factor 1)

  • Background

    This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
  • Synonyms

    GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human GATA1-140H Recombinant Human GATA1 Protein, His-tagged E.coli His
    Human GATA1-2052H Recombinant Human GATA1, GST-tagged Wheat Germ GST
    Human GATA1-28476TH Recombinant Human GATA1, His-tagged E.coli His
    Human GATA1-689HCL Recombinant Human GATA1 cell lysate N/A
    Human GATA1-1962HFL Recombinant Full Length Human GATA1 Protein, N-His-tagged E.coli His
    Human GATA1-6938HF Recombinant Full Length Human GATA1 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse Gata1-474M Recombinant Mouse Gata1 Protein, His-tagged E.coli His
    Mouse GATA1-6222M Recombinant Mouse GATA1 Protein Mammalian Cell His
    Mouse GATA1-3481M Recombinant Mouse GATA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse GATA1-3481M-B Recombinant Mouse GATA1 Protein Pre-coupled Magnetic Beads HEK293
    Rat Gata1-475R Recombinant Rat Gata1 Protein, His-tagged E.coli His
    Rat GATA1-2481R Recombinant Rat GATA1 Protein Mammalian Cell His
    Rat GATA1-2137R-B Recombinant Rat GATA1 Protein Pre-coupled Magnetic Beads HEK293
    Rat GATA1-2137R Recombinant Rat GATA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Chicken GATA1-7013C Recombinant Chicken GATA1 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • GATA1 Related Articles

    GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor networkCDK6;YEATS4;MYOD1;CREBBP;GATA1;PTCRA;CBX4;CEBPA;ADA
    Factors involved in megakaryocyte development and platelet productionSH2B3;GATA2A;KIF9;CABLES2;ITPK1;BA2;AKAP1;KIF3C;MFN2
    HemostasisGATA1;ZFPM2A;SERPINA1L;DOCK9;NFE2;F11R.2;F3B;MAFF;PIK3R6
    IL-3 Signaling PathwayGATA1A;GATA2A;GATA1;BIRC5A;SPI1B;KCNIP3;GATA2;KCNIP3B;GSK3AB
    Notch-mediated HES/HEY networkMYB;YY1;MYOD1;TLE1;RCAN1;HEY1;ASCL1;BGLAP;CTBP1
    Signaling events mediated by HDAC Class ISIRT4;SIRT7;WDR77;TFCP2;PRMT5;FKBP3;SIRT2;GATA2;NR2C1
    Signaling events mediated by HDAC Class IIANKRA2;BCOR;GATA1

    GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.

    Function Related Protein
    C2H2 zinc finger domain bindingEHMT2;TAF9;GATA1;GATA2;ZXDC;EHMT1;WT1;EBF1;THAP7
    DNA bindingHOXA2B;TIGD1;MIER1A;MBD3A;RABGAP1;SETBP1;FOXF2A;RFXANK;OTUD7B
    DNA binding, bendingGATA1;SRY;HHEX;FOXC1;TOP2B;LEF1;FOXL1;TFAM;FOXI1
    RNA polymerase II core promoter proximal region sequence-specific DNA bindingPOU1F1;SMAD6;GLI2;ZNF713;HAND1;SNAI3;CEBPZ;PHOX2B;EHF
    RNA polymerase II core promoter sequence-specific DNA bindingMAZ;ZNF335;PAX8;SMYD3;SMAD1;SP3;NFIL3;STAT5A;HNF4A
    RNA polymerase II regulatory region sequence-specific DNA bindingSOHLH1;ALX1;SUV39H1;ZNF773;NFKB1;POU3F4;ATF1;MYOG;ETV7
    RNA polymerase II transcription factor bindingANKRD1;PITX2;TEAD3;CREBBP;KLF4;GSK3B;GATA1A;ZFPM2;TBX3
    chromatin DNA bindingPRDM14;WBP2;BCL6;GATA1;RELA;FOXO3;RXRA;HIST1H1B;NEUROG3
    core promoter bindingHDAC1;CALCOCO1;FOXP3;SPI1;CLOCK;PYDC3;MYOG;SFPQ;HDAC2
    enhancer sequence-specific DNA bindingKLF6A;LMO4;TWIST1B;TBX19;HMGB2;XBP1;SOX9;GATA2;MYT1
    p53 bindingBRD7;MAPKAPK5;CREBBP;PLK3;RNF34;ZFP385C;PSME3;NTRK3;TP53BP1
    protein bindingVCL;LPAR2;OPA1;SCG5;DPH2;FGF12;NDUFS3;TLR3;SH3GLB2
    sequence-specific DNA bindingSNAI2;ESRRB;POU3F3;POU4F1;VENTX;PRDM16;MAFF;MAFBA;NR2F2
    transcription factor activity, sequence-specific DNA bindingARNT2;GPBP1L1;RUNX1;FOXD1;GRHL2A;BACH1;ZNF83;ZNF334;SRF
    transcription regulatory region sequence-specific DNA bindingTFAP2A;NR5A5;NFE2L1A;FOXN1;PER2;EGR1;MKL1;GATA1;TBX18
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingTXK;ALS2CR8;ZIC1;TCF4;GATA3;FLI1;DLX5;CEBPE;PGR
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingCEBPA;BHLHA15;STAG1;FOXO3;CREB3L4;GATA1;REST;NKX2;PAX9
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific bindingMYPOP;NKX3-2;NFATC4;AEBP2;HHEX;BCL11A;ESRRA;TBX15;POU4F2
    zinc ion bindingADAT3;LMO3;ZNRF3;RNF114;NPSN;DBF4B;UNKL;TRIM3B;LMO4A

    GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.

    FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL

    Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
    Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).
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