GATA1 Protein

GATA1

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GATA1

Official Full Name GATA binding protein 1 (globin transcription factor 1)
Background This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
Synonyms GATA1; GATA binding protein 1 (globin transcription factor 1); GF1; GF-1; NFE1; XLTT; ERYF1; NF-E1; XLANP; XLTDA; GATA-1; erythroid transcription factor; GATA-binding factor 1; NF-E1 DNA-binding protein; transcription factor GATA1; nuclear factor, erythroid 1; globin transcription factor 1; erythroid transcription factor 1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GATA1-140H Recombinant Human GATA1 Protein, His-tagged E.coli His
    Human GATA1-2052H Recombinant Human GATA1, GST-tagged Wheat Germ GST
    Human GATA1-28476TH Recombinant Human GATA1, His-tagged E.coli His
    Human GATA1-689HCL Recombinant Human GATA1 cell lysate N/A
    Mouse Gata1-474M Recombinant Mouse Gata1 Protein, His-tagged E.coli His
    Mouse GATA1-6222M Recombinant Mouse GATA1 Protein Mammalian Cell His
    Rat GATA1-2481R Recombinant Rat GATA1 Protein Mammalian Cell His
    Rat Gata1-475R Recombinant Rat Gata1 Protein, His-tagged E.coli His
    Chicken GATA1-7013C Recombinant Chicken GATA1 Mammalian Cell His

    GATA1 involved in several pathways and played different roles in them. We selected most pathways GATA1 participated on our site, such as C-MYB transcription factor network, Factors involved in megakaryocyte development and platelet production, Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GATA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    C-MYB transcription factor network CBX4; ADORA2B; CSF1R; CREBBP; CDKN1B; MYC; YEATS4; TRIM28; GATA1; CLTA
    Factors involved in megakaryocyte development and platelet production GATA6; KIF26A; HBB-Y; ITPK1; IRF2A; KIF11; KIF4A; HBBE2; ZFPM2A; DOCK10
    Hemostasis TAE1; CBX5; NFE2; MAFGB; CEACAM1; HBG2; ESAMA; SLC7A8A; C6orf25; KCNMB2
    IL-3 Signaling Pathway GSK3AB; GATA1A; GATA1; BIRC5A; KCNIP3B; KCNIP3; GATA2A; SPI1B; PILRB; BMX
    Notch-mediated HES/HEY network ASCL1; HEY1; MYOD1; CTBP1; GATA6; TLE1; MYB; HES6; BGLAP; RCAN1
    Signaling events mediated by HDAC Class I GATA1; GATA2; SIRT2; WDR77; SIRT4; NR2C1; PRMT5; MXD1; SIRT5; TFCP2
    Signaling events mediated by HDAC Class II BCOR; GATA1; ANKRA2

    GATA1 has several biochemical functions, for example, C2H2 zinc finger domain binding, DNA binding, DNA binding, bending. Some of the functions are cooperated with other proteins, some of the functions could acted by GATA1 itself. We selected most functions GATA1 had, and list some proteins which have the same functions with GATA1. You can find most of the proteins on our site.

    Function Related Protein
    C2H2 zinc finger domain binding EHMT1; THAP7; LEF1; TAF9; EHMT2; U2AF2; GATA2; EBF1; GATA1; ZXDC
    DNA binding ZNF434; MSL3; HIST3H3; TAF13; HOXD13A; HOXC11A; HIST1H2BM; HIST1H2BK; ZNF287; SOX2
    DNA binding, bending LEF1; CRIP1; TERF1; TFAM; GATA1; HHEX; TOP2A; FOXC1; FOXD4; FOXD1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding CEBPB; TCF4; IRF4; ZIC3; FOSL2; EBF2; TBX15; ETV1; FOXD1; HELT
    RNA polymerase II core promoter sequence-specific DNA binding H3F3B; SMAD5; SMAD1; SOX11; NFIL3; STAT6; RREB1; ZNF335; RBPJ; PAX6
    RNA polymerase II regulatory region sequence-specific DNA binding RXRG; GFI1AA; GATA4; ARHGAP35; HES6; MEF2C; NHLH2; MYOD1; SP3; ZSCAN2
    RNA polymerase II transcription factor binding GATA6; HCLS1; MEF2A; TAL1; ZFPM2A; MIXL1; KLF4; TEAD3; XBP1; GATA2A
    chromatin DNA binding FOXO3; PER1; RARA; APEX1; GRHL2; H1F0; THRA; VAX2; ACTN4; NOTCH1
    core promoter binding MYBBP1A; E2F7; CLOCK; IRF9; ARNTL; RELB; IFI203; GTF2B; ELK1; CALCOCO1
    enhancer sequence-specific DNA binding HMGB2; ISL1; YY1; GATA2; KLF7B; LMO4; GATA5; GATA1; TBX19; LDB1
    p53 binding MSX1; CREBBP; RNF20; ZFP346; TP53; NTRK3; PSME3; ZNF385B; ZMAT3; GATA1
    protein binding APOOL; CHD4; NRIP3; ERLIN2; PTGIS; MON2; PRPF4B; KRTAP4-11; SRSF1; SERPINA3K
    sequence-specific DNA binding FOXD1; HSFX1; PPARDB; LHX2A; NR2F1B; ARNTL; SALL3B; LHX1B; CAMTA2; LMX1BB
    transcription factor activity, sequence-specific DNA binding BACH2; FOXC1B; MYT1; PGBD1; HOXC4; MYCL1; MAFGB; HMGB2; RAB11FIP4A; ZNF23
    transcription regulatory region sequence-specific DNA binding TFAP2A; ARNTL1A; PITX2; BTBD8; CRY2; NFE2L3; DDIT3; NR5A1; NFE2L2B; HIF1AL
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ETV6; ETV1; PITX3; NFKB2; CARF; NFIA; FLI1; NEUROG3; NR6A1; BSX
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding TP53; CREB3L4; MAFK; ELF5; ALX4; STAG2; PLAGL1; GATA1A; CREB3L3; MAFBA
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding HINFP; ZBTB20; HES1; GFI1; ZBTB7A; PROX1; KLF17; IFI16; HHEX; HOXA2
    zinc ion binding UBR4; KNG1; ZDHHC5A; ZIM2; ADAM28; LIMS2; ZNF8; RFFL; BMI1; ADAMTS5

    GATA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GATA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GATA1.

    FRS3; PRKAB2; HOXA1; KRTAP10-5; CCDC24; FBF1; RADIL

    Wang, KP; Zhao, LQ; et al. Differential co-expression analysis of rheumatoid arthritis with microarray data. MOLECULAR MEDICINE REPORTS 10:2421-2426(2014).
    Battista, JM; Tallmadge, RL; et al. Hematopoiesis in the equine fetal liver suggests immune preparedness. IMMUNOGENETICS 66:635-649(2014).

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