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Official Full Name major histocompatibility complex, class I, F
Background This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Synonyms HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli His
    Human HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 N/A

    hla-f involved in several pathways and played different roles in them. We selected most pathways hla-f participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with hla-f were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis SH3GLB1B; GRK6; TRAF6; ZFYVE27; HLA-C; VPS24; PARD6B; CDC42; FAM125A; ARRB2B
    Cell adhesion molecules (CAMs) SELE; PTPRC; MHC2DEB; NRXN1; ICAM1; CD274; PTPRFB; ITGB7; HLA-DOA; NADL1.2
    Antigen processing and presentation KIR2DS5; KLRD1; HSPA8; TAP1; RFXANK; KLRC3; H2-AB1; CD8A; HSPA5; CTSL1
    Type I diabetes mellitus IL1B; IL12A; LTA; ICA1; HLA-B; PTPRN; HLA-G; CPE; FAS; TNF
    HTLV-I infection MAP3K3; H2-Q10; HLA-C; PRKACA; TGFB1; DVL1; MYB; IL1R1; NFATC3; MSX2
    Herpes simplex infection CDK1; TAF4B; IFNA7; CFP; CD74; RNASEL; HLA-C; H2-AA; NFKBIAB; SRSF1B
    Epstein-Barr virus infection POLR2L; NCOR2; PSMC2; ITGAL; SKP2; VIM; POLR2J3; TAB1; FCER2; NFKBIE
    Viral carcinogenesis SCIN; HIST1H4J; GSN; CCNE1; GTF2H4; POLB; GTF2A2; SRC; GTF2H3; HDAC7A
    Autoi CD28; CD80; IFNA6; HLA-E; IFNA5; HLA-DMB; HLA-F; TPO; HLA-G; Ifna15
    ne thyroid disease Fasl; HLA-DMA; HLA-E; GZMB; IFNA2; IFNA7; HLA-DQA2; HLA-DMB; HLA-B; IFNA13
    Allograft rejection HLA-DMB; HLA-DRB1; H2-AB1; HLA-DMA; HLA-DOB; CD80; HLA-DPA1; CD28; HLA-DQB1; IL5
    Graft-versus-host disease KIR3DL1; Fasl; IL6; HLA-DOA; HLA-DOB; HLA-C; HLA-G; IFNG; CD86; IL1B
    Viral myocarditis HLA-DQA1; HLA-DMB; ABL1; MYH7; CCND1; SGCA; RAC1; HLA-DMA; RAC3; HLA-E

    hla-f has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by hla-f itself. We selected most functions hla-f had, and list some proteins which have the same functions with hla-f. You can find most of the proteins on our site.

    Function Related Protein
    TAP1 binding TAP2; TAPBP; HLA-F; TAP1
    TAP2 binding TAPBP; TAP1; HLA-F
    peptide antigen binding HLA-DRB5; DHCR24; TAP1; MR1; MHC1UIA; MHC1ZKA; MHC1UXA2; HLA-DRB4; MHC1ZHA; MHC1ZFA
    receptor binding NTF7; HCK; MYO1C; NPFF; CNPY3; ACOX1; CTNND1; TNFSF10; HAND2; DHRS4

    hla-f has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with hla-f here. Most of them are supplied by our site. Hope this information will be useful for your research of hla-f.

    q81nr7_bacan; ilvD

    Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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