HLA-F Protein


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Official Full Name major histocompatibility complex, class I, F
Background This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Synonyms HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli His
    Human HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli His
    Human HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 N/A

    HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis GRK7; CAPZA1A; HSPA6; CXCR2; RUFY1; ARF1L; IL2RB; WWP1; ADRB2B; IGF1RB
    Cell adhesion molecules (CAMs) JAM2A; VCAN; HLA-A; HLA-DRB3; NLGN3; SELE; MHC2A; CLDNK; BF1; CD80
    Antigen processing and presentation CTSL1; HLA-DOB; HLA-C; HSP90AB1; IFNG; PSME2; HLA-A; HLA-DQB1; NFYB; RFX5
    Type I diabetes mellitus CD86; FASLG; HLA-B; HLA-DQA2; HLA-DRB3; HLA-DMA; HLA-DRB5; H2-Q10; HLA-DPB1; HLA-C
    Herpes simplex infection TNFSF14; HLA-DOA; PPP1CA; STAT1B; SRPK1B; PILRA; DAXX; HLA-DRA; IFNPHI1; STAT1A
    Epstein-Barr virus infection PRKACG; PTMA; TYK2; PSMC2; YWHAH; HSPA1A; POLR1C; SPN; PSMD6; MAP3K14
    Viral carcinogenesis ACTN1; DLG1; H2-Q10; RBL1; GTF2H4; HIST1H2BP; CREB3L3; PSMC1; LTBR; CREB3L1
    ne thyroid disease CD86; IFNA2; FASLG; IFNA16; HLA-DRA; PRF1; IFNA7; IL4; H2-AB1; IFNA12
    Allograft rejection IL10; HLA-DOA; HLA-DQA2; HLA-DRB5; IL5; HLA-E; GZMB; HLA-DQA1; HLA-DRB3; IL4
    Graft-versus-host disease HLA-DMB; PRF1; HLA-DRB4; KLRD1; FAS; H2-Q10; HLA-DRB3; IFNG; IL6; HLA-B
    Viral myocarditis HLA-DRB3; LAMA2; SGCA; Casp3; HLA-DRB1; HLA-DQA1; EIF4G3; CXADR; CCND1; SGCD

    HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

    Function Related Protein
    TAP1 binding HLA-F; TAPBP; TAP2; TAP1
    TAP2 binding HLA-F; TAPBP; TAP1
    peptide antigen binding HLA-C; MHC1ZHA; HLA-DRB3; HLA-DRB4; MHC1ZE; MAML1; MHC1UXA2; MHC1ZDA; DHCR24; TUBB3
    receptor binding TMED1; ADIPOQ; PKD2; F2RL1; WNT2BA; SERPINE2; PTK6B; RARA; RIPK2; C5

    HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

    q81nr7_bacan; ilvD

    Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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