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HLA-F

Official Full Name

major histocompatibility complex, class I, F
Overview

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
Synonyms

HLA-F; major histocompatibility complex, class I, F; HLA class I histocompatibility antigen, alpha chain F; alpha chain F; CDA12; HLA 5.4; HLA class I histocompatibility antigen; HLA F antigen; HLAF; HLAF_HUMAN; Leukocyte antigen F; MHC class I antigen F; HLA class I molecule; MHC class Ib antigen; HLA-5.4; HLA-CDA12;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HLA-F-239H	Recombinant Human HLA-F, His-tagged	E.coli	His	22-305aa	Inquiry
Human	HLA-F-331HCL	Recombinant Human HLA-F lysate	HEK293	N/A		Inquiry
Human	HLA-F-3439H	Recombinant Human HLA-F protein, His-tagged	E.coli	His	21-298 aa	$319 / 25ug

Involved Pathway
Protein Function
Interacting Protein
Other Resource

HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Endocytosis	IL2RB;PARD6GB;CYTH4B;PARD6B;IGF1R;ARRB2;CHMP7;RAB11FIP2;ARPC5B
Phagosome	SCARB1;DYNC1LI2;SEC22BB;COLEC12;HLA-E;TUBA1A;RAB7;ATP6V1C2;ATP6V1C1
Cell adhesion molecules (CAMs)	BLA;PRPSAP2;PTPRF;ITGB1A;CLDN2;CD80;CLDN9;MPZ;NRCAM
Antigen processing and presentation	HLA-DQA2;NFYA;CD8B;CTSL1;Ctsl;PDIA3;TAP1;HSPA1A;HSPA1B
Type I diabetes mellitus	PTPRN2;CPE;CD28;HLA-DRB5;IL12B;GZMB;HLA-DQA1;IL12A;HLA-DRB3
HTLV-I infection	TNFRSF13C;PDGFRA;HLA-C;VDAC2;ATF3;CDC16;MYBL1;TP53INP1;BUB1B
Herpes simplex infection	C5;SP100;TRAF1;PER1;ABCB3L1;TAF3;TBPL1;GTF2I;BLB2
Epstein-Barr virus infection	YWHAH;TAB1;HSPA1B;TYK2;PIK3CA;HLA-C;HSPA2;HLA-G;SND1
Viral carcinogenesis	GTF2H3;YWHAH;CREB5;HDAC10;RBL1;HIST1H2BA;HIST1H2BN;CDC20;REL
Autoi	H2-AB1;TSHB;IFNA21;CD80;FASLG;IL4;FAS;H2-Q10;TPO
ne thyroid disease	HLA-DOA;Fasl;IFNA10;IFNA8;GZMB;HLA-DQB1;HLA-B;Il2;CD40LG
Allograft rejection	IL12A;CD86;HLA-DRB1;HLA-G;PRF1;CD28;HLA-F;HLA-A;HLA-DOB
Graft-versus-host disease	HLA-DMA;HLA-DOA;IL1B;CD86;CD28;H2-AA;HLA-DRB3;HLA-C;HLA-DQB1
Viral myocarditis	HLA-B;HLA-DQB1;SGCA;Casp3;CYCS;ACTB;ITGB2;HLA-DOB;H2-Q10

HLA-F has several biochemical functions, for example, TAP1 binding, TAP2 binding, peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

Function	Related Protein
TAP1 binding	TAP1;TAP2;TAPBP;HLA-F
TAP2 binding	HLA-F;TAPBP;TAP1
peptide antigen binding	MHC1ZDA;AZGP1;MHC1UBA;TUBB3;MHC1UFA;HLA-E;MR1;MHC1ZFA;MAML1
receptor binding	NPPA;AGRP2;PIPOX;ARPP19;Artn;Fgf15;SLC39A1;KCNA5;WNT2BB

HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

q81nr7_bacan; ilvD

Gene Family

Research Area

Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).

Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).