HLA-F

  • Official Full Name

    major histocompatibility complex, class I, F
  • Overview

    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms

    HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli Human His 21-298 aa
HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli Human His 22-305aa
HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 Human Non

    Involved Pathway

    HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endocytosis TGFB2,LDLRA,VPS45,KDRL,ACAP2,RLN1,EPS15L1,RNF41,SNX12,WASH
    Cell adhesion molecules (CAMs) CLDN8,PVRL2,CD8A,CLDN19,PRPSAP2,ITGA8,CLDNJ,MHC2DCB,ITGAV,Ntng2
    Viral carcinogenesis SRC,GTF2A1,IRF3,MAPK1,KRAS,GTF2H2,HIST1H2BC,PIK3CD,TRAF3,HDAC11
    Allograft rejection HLA-C,Il2,HLA-DPB1,HLA-DRB3,HLA-DQB1,CD80,IL5,FASLG,HLA-DRA,HLA-DOB
    Autoi HLA-DRB5,TSHB,CD40LG,HLA-DQB1,IL5,HLA-E,HLA-DMB,IFNA6,HLA-A,IFNA16
    Epstein-Barr virus infection ENTPD8,MAPK10,IL10RB,SYK,HSPA2,TRAF2,CD44,SNW1,MAP2K6,PSMD6
    Herpes simplex infection HLA-C,CASP8,PVRL1,NXF2,PPP1CB,C3,CFP,SRSF1A,SRSF1B,IRF7
    Type I diabetes mellitus H2-AA,H2-AB1,IL1B,GAD1,HLA-DQA2,HLA-DMA,HLA-DRB4,INS2,HLA-B,HLA-DOB
    HTLV-I infection SLC25A31,STAT5B,ATF4,POLE3,PDGFRA,NFKB1,FZD9,TCF3,TGFBR1,HLA-DQA2

    Protein Function

    HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

    Function Related Protein
    TAP1 binding TAPBP,TAP1,TAP2
    TAP2 binding TAPBP,TAP1
    peptide antigen binding H2-AA,HLA-DRA,HLA-DPB1,MHC1UDA,HLA-G,HLA-DRB1,H2-AB1,MHC1UXA2,MHC1ZHA,MR1
    receptor binding GLA,CD58,GIPC1,HNF4A,MTSS1,PTK2AA,ABL1,IFNL3,WNT4B,PVR

    Interacting Protein

    HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

    q81nr7_bacan;ilvD

    Resources

    References

    • Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    • Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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