HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | POLR3G,TYK2,IL10RA,SND1,PTMA,MAP2K3,IRAK1,GTF2B,GTF2E2,TRAF1 |
| Antigen processing and presentation | H2-AB1,HSPA1B,KLRC3,CD74,TNF,HLA-DPB1,IFI30,HSPA2,NFYB,CTSL1 |
| Viral myocarditis | CD86,ITGB2,CXADR,FYN,CD28,CD40LG,HLA-DRB1,HLA-DRA,RAC3,HLA-DMB |
| ne thyroid disease | TG,IFNA7,HLA-DMB,Fasl,CD86,IFNA5,GZMB,HLA-DOA,IFNA1,FAS |
| Cell adhesion molecules (CAMs) | CLDNJ,BLB2,ITGA6B,CD226,CD22,CLDN17,H2-Q10,ITGAV,H2-AA,CD8B1 |
| Viral carcinogenesis | MRPS18B,HDAC7,HDAC3,STAT5A,RHOA,CDC42,HIST2H2BB,VDAC3,IRF3,TBP |
| Herpes simplex infection | IFNAR1,TNFRSF1A,RNASEL,FADD,SRSF7B,CCL5,SFRS9,C3A.1,IFNA8,HLA-DRA |
| Autoi | TSHR,HLA-A,Ifna15,FAS,TPO,CD28,PRF1,IFNA1,IFNA16,TG |
| Type I diabetes mellitus | HLA-DOA,HLA-DPB1,GAD1,INS1,HLA-E,HLA-DRB3,Il2,HLA-DOB,HLA-G,IL12A |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP2 binding | TAP1,TAPBP |
| TAP1 binding | TAP1,TAPBP,TAP2 |
| peptide antigen binding | BF2,HLA-B,MHC1UHA,MHC1UBA,HLA-DPB1,H2-AB1,MHC1UIA,TAP1,HLA-DPA1,HLA-DRB5 |
| receptor binding | FIS1,ACOX3,Itga10&Itgb1,C3,PTPRD,CNPY3,ACOT2,LAMA3,F7,CD160 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
