HLA-F

  • Official Full Name

    major histocompatibility complex, class I, F
  • Overview

    This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.
  • Synonyms

    HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
Cat.# Product name Source (Host) Species Tag Protein Length Price
HLA-F-3439H Recombinant Human HLA-F protein, His-tagged E.coli Human His 21-298 aa
HLA-F-239H Recombinant Human HLA-F, His-tagged E.coli Human His 22-305aa
HLA-F-331HCL Recombinant Human HLA-F lysate HEK293 Human Non

    Involved Pathway

    HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Graft-versus-host disease HLA-DRA,KIR3DL2,CD80,HLA-B,HLA-DRB5,HLA-DOB,Il2,HLA-DRB4,HLA-DQA2,CD86
    Cell adhesion molecules (CAMs) NRXN1,CLDN6,CLDN5A,CLDN7A,NCAM1,MHC2A,PVRL1,MPZ,NRXN3,CDH3
    Antigen processing and presentation HSPA8,HSPA1B,HLA-DQA1,HLA-DQA2,PDIA3,KIR2DL3,Ctsl,KIR2DL4,PSME1,KIR2DS2
    Viral myocarditis RAC1,RAC3,HLA-DRA,HLA-DRB1,H2-AB1,Casp3,HLA-G,H2-AA,ACTB,CASP8
    Endocytosis ARR3B,IL2RGA,CCR5,GIT2A,VPS37A,EHD1B,ARFGEF2,VPS37B,PRKCZ,NTRK1
    Type I diabetes mellitus HLA-DQA2,HLA-DOB,HLA-A,IL1B,INS,Fasl,H2-AA,HLA-B,HLA-G,H2-AB1
    Phagosome CTSLA,TUBA1L,NOS1,TUBA1L2,SEC61A1,ATP6V0A2B,DYNC1I2A,MHC1UEA,SCARB1,MRC2
    Epstein-Barr virus infection TYK2,EIF2AK1,IKBKB,CCNA1,MAP2K6,SHFM1,NFKBIB,FGR,SPN,MAPK11
    ne thyroid disease IFNA12,HLA-DRB5,HLA-DOA,HLA-DRB1,IFNA5,IFNA1,HLA-E,IL4,Il2,IFNA13

    Protein Function

    HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.

    Function Related Protein
    receptor binding TGFB2,ADAM10,DECR2,IZUMO1,F7,TAC1,GSTK1,HSD17B4,RSPO1,ABL2
    TAP2 binding TAPBP,TAP1
    peptide antigen binding MHC1ZDA,TAP1,TUBB3,MHC1ZBA,HLA-G,MR1,HLA-DRB4,HLA-E,H2-AA,BF2
    TAP1 binding TAPBP,TAP1,TAP2

    Interacting Protein

    HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.

    q81nr7_bacan;ilvD

    Resources

    References

    • Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
    • Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).

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