HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Type I diabetes mellitus | HLA-E,CD28,IL1B,PRF1,IL1A,HLA-C,CD86,FAS,HLA-DQA1,HLA-DPA1 |
| Antigen processing and presentation | HLA-A,HLA-DPB1,HLA-DRB3,KIR3DL2,KIR2DS3,KIR2DS2,NFYC,CD8B,HSPA1A,CD8B1 |
| Epstein-Barr virus infection | TBK1,HLA-A,PIK3R5,PSMD3,CD38,PSMC2,XPO1,AKT2,HSPB2,YWHAB |
| Phagosome | MHC2A,TUBA7L,MHC1UXA2,RAB5AA,BLB1,HLA-DQA2,ATP6V0E1,TAP1,THBS3,TUBB1 |
| Endocytosis | SH3GL3B,CHMP1B,STRUMPELLIN,ASAP2B,STAM2,FAM21C,HRASB,HLA-C,PDCD6IP,TGFBR2 |
| Herpes simplex infection | C1QBP,ABCB3L1,IFNA10,TAF5L,MHC2A,IL15,STAT1A,TBP,OAS1,SRSF2 |
| Cell adhesion molecules (CAMs) | CLDN17,CLDN14,NEGR1,CD40LG,CLDNG,CDH3,CLDNJ,ICOS,F11R.1,HLA-DRB3 |
| Graft-versus-host disease | HLA-A,HLA-DOB,KIR2DL3,HLA-DRA,HLA-C,HLA-DOA,HLA-G,IFNG,IL6,HLA-DRB3 |
| ne thyroid disease | Il2,IFNA7,HLA-DQB1,CD86,FAS,HLA-DPA1,HLA-G,HLA-DPB1,HLA-DMA,HLA-DRA |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | DHCR24,TUBB3,MHC1UIA,MHC1UBA,BF2,H2-AB1,MHC1ZBA,MHC1ZDA,MR1,H2-Q10 |
| TAP2 binding | TAPBP,TAP1 |
| TAP1 binding | TAPBP,TAP1,TAP2 |
| receptor binding | FYB,DAO,NXPH3,TYROBP,NRTN,GUSB,FGF18B,EDA,SELPLG,HCK |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
