HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | TGFB2,LDLRA,VPS45,KDRL,ACAP2,RLN1,EPS15L1,RNF41,SNX12,WASH |
| Cell adhesion molecules (CAMs) | CLDN8,PVRL2,CD8A,CLDN19,PRPSAP2,ITGA8,CLDNJ,MHC2DCB,ITGAV,Ntng2 |
| Viral carcinogenesis | SRC,GTF2A1,IRF3,MAPK1,KRAS,GTF2H2,HIST1H2BC,PIK3CD,TRAF3,HDAC11 |
| Allograft rejection | HLA-C,Il2,HLA-DPB1,HLA-DRB3,HLA-DQB1,CD80,IL5,FASLG,HLA-DRA,HLA-DOB |
| Autoi | HLA-DRB5,TSHB,CD40LG,HLA-DQB1,IL5,HLA-E,HLA-DMB,IFNA6,HLA-A,IFNA16 |
| Epstein-Barr virus infection | ENTPD8,MAPK10,IL10RB,SYK,HSPA2,TRAF2,CD44,SNW1,MAP2K6,PSMD6 |
| Herpes simplex infection | HLA-C,CASP8,PVRL1,NXF2,PPP1CB,C3,CFP,SRSF1A,SRSF1B,IRF7 |
| Type I diabetes mellitus | H2-AA,H2-AB1,IL1B,GAD1,HLA-DQA2,HLA-DMA,HLA-DRB4,INS2,HLA-B,HLA-DOB |
| HTLV-I infection | SLC25A31,STAT5B,ATF4,POLE3,PDGFRA,NFKB1,FZD9,TCF3,TGFBR1,HLA-DQA2 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| TAP1 binding | TAPBP,TAP1,TAP2 |
| TAP2 binding | TAPBP,TAP1 |
| peptide antigen binding | H2-AA,HLA-DRA,HLA-DPB1,MHC1UDA,HLA-G,HLA-DRB1,H2-AB1,MHC1UXA2,MHC1ZHA,MR1 |
| receptor binding | GLA,CD58,GIPC1,HNF4A,MTSS1,PTK2AA,ABL1,IFNL3,WNT4B,PVR |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
