HLA-F
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Official Full Name
major histocompatibility complex, class I, F -
Overview
This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. -
Synonyms
HLA-F;major histocompatibility complex, class I, F;HLA class I histocompatibility antigen, alpha chain F;alpha chain F;CDA12;HLA 5.4;HLA class I histocompatibility antigen;HLA F antigen;HLAF;HLAF_HUMAN;Leukocyte antigen F;MHC class I antigen F;HLA class I molecule;MHC class Ib antigen;HLA-5.4;HLA-CDA12
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| HLA-F-3439H | Recombinant Human HLA-F protein, His-tagged | E.coli | Human | His | 21-298 aa | |
| HLA-F-239H | Recombinant Human HLA-F, His-tagged | E.coli | Human | His | 22-305aa |
|
| HLA-F-331HCL | Recombinant Human HLA-F lysate | HEK293 | Human | Non |
|
Involved Pathway
HLA-F involved in several pathways and played different roles in them. We selected most pathways HLA-F participated on our site, such as Endocytosis,Phagosome,Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-F were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Viral carcinogenesis | NFKB2,HLA-C,HIST2H2BE,SP100,RBL2,KAT2A,HPN,PMAIP1,CCNA2,HDAC3 |
| Viral myocarditis | LAMA2,CCND1,HLA-DRB4,SGCB,HLA-DQA2,RAC2,BID,HLA-DPA1,ITGB2,HLA-DOA |
| Herpes simplex infection | BMA2,PVRL2,SRSF2,OAS1,HCFC2,CUL1,EIF2AK4,IFNA8,CRFB2,GTF2I |
| Phagosome | ATP6V1C1B,FCGR2A,HLA-A,PIK3C3,ITGA5,ATP6V1C1,TAP1,MHC2A,ATP6V1C1A,TUBA1L2 |
| ne thyroid disease | IFNA21,HLA-DMB,CD40LG,IFNA14,TPO,HLA-DOA,IFNA5,Ifna15,TSHR,CD40 |
| HTLV-I infection | NFATC3,TNF,EP300,IL2RG,FZD3,FDPS,WNT9A,HLA-DQA2,NFKB2,H2-AB1 |
| Type I diabetes mellitus | Il2,GZMB,INS,HLA-DOB,HLA-DRA,GAD2,IL12A,HLA-DQA2,HLA-A,HLA-DMA |
| Epstein-Barr virus infection | PSMD11,HLA-B,TYK2,MAP2K7,TP53,CCNA2,MDM2,HLA-DQA1,POLR2J3,PSMD6 |
| Cell adhesion molecules (CAMs) | NRXN3,BF2,OCLN,NEGR1,NLGN2A,PECAM1,HLA-DOA,ITGAL,SDC2,F11R.1 |
Protein Function
HLA-F has several biochemical functions, for example, TAP1 binding,TAP2 binding,peptide antigen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-F itself. We selected most functions HLA-F had, and list some proteins which have the same functions with HLA-F. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peptide antigen binding | HLA-A,MR1,HLA-DRB4,HLA-G,HLA-DRA,HLA-DRB5,CD209,BF2,MHC1ZKA,HLA-C |
| receptor binding | PPY,FGF1A,CRTAM,NTF7,MAP7,HCST,HMGCL,PVRL1A,RSPO2,ACOX2 |
| TAP2 binding | TAPBP,TAP1 |
| TAP1 binding | TAP2,TAPBP,TAP1 |
Interacting Protein
HLA-F has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-F here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-F.
q81nr7_bacan;ilvD
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References
- Guo, XC; Winkler, CA; et al. Evaluation and Integration of Genetic Signature for Prediction Risk of Nasopharyngeal Carcinoma in Southern China. BIOMED RESEARCH INTERNATIONAL :-(2014).
- Jabeen, A; Miranda-Sayago, JM; et al. Quantified Colocalization Reveals Heterotypic Histocompatibility Class I Antigen Associations on Trophoblast Cell Membranes: Relevance for Human Pregnancy. BIOLOGY OF REPRODUCTION 89:-(2013).
