Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

IGF2BP2

  • Official Full Name

    Insulin-like growth factor 2 mRNA binding protein 2

  • Overview

    Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of Growth Hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of foetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism. IGFBP-2 is an unglycosylated polypetide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. The serum concentration of IGFBP-2 increases in fasting, after major surgery and after trauma, but the increasing of the concentration is most intensive in malignant diseases. The correlation of the IGFBP-2 level to the degree of progression is a striking feature in various tumor types as is the normalization of the IGFBP-serum levels after remission. During the GH-therapy, e.g. in short stature and in GH-abuse (doping) the IGFBP-2 level decreases. In Trisomy 18 IGFBP-2 in maternal serum is decreased and IGFBP-1 is increased; therefore the ratio IGFBP-2 /IGFBP-1 is a marker for this chromosome abnormality. Transgenic organisms are a good opportunity to investigate the function of genes or proteins. The mouse model is a well-suited system for investigation of the relevance of IGFBP-2 in physiological and pathological processes. Over expression of the IGFBP-2 gene in mice results in a weight reduction of 30% in spleen and moderately reduced weight in other organs. Effects of IGFBP-2 on the organism can be compensated through the modified expression of other IGF-Binding proteins. Especially in tumor biology the mouse system enables investigation of the systemic relevance of IGFBP-2. IGFBP-2 influences tumor cells as it induces catalase activity in adrenocortical cells. Furthermore IGFBP-2 interacts with tumor cells via its RGD-amino acid sequence and seems to stimulate cell invasion of glioma cells.
  • Synonyms

    RP23-50H13.1; C330012H03Rik; IMP-2; Imp2; Neilsen; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; VICKZ family member 2; insulin-like growth factor 2 mRNA-binding protein 2; insulin-like growth factor 2, binding protein 2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
  • C
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IGF2BP2-3874H Recombinant Human IGF2BP2 protein, His&GST-tagged Insect Cells His/GST Met1-Lys599
Human IGF2BP2-639HCL Recombinant Human IGF2BP2 cell lysate Insect Cell N/A
Human IGF2BP2-92HFL Recombinant Full Length Human IGF2BP2 Protein, C-Flag-tagged Mammalian cells Flag
Human IGF2BP2-1862H Recombinant Human IGF2BP2 protein, His & T7-tagged E.coli His/T7 Ser141~Pro384 (Accession # Q9Y6M1)
Human IGF2BP2-1390H Recombinant Human IGF2BP2 Protein, His/T7-tagged E.coli His/T7
Human IGF2BP2-1155H-B Recombinant Human IGF2BP2 Protein Pre-coupled Magnetic Beads HEK293
Human IGF2BP2-2618H Recombinant Human IGF2BP2 Protein (Met1-Thr220), N-T7 and C-His tagged E.coli N-T7 and C-His Met1-Thr220
Human IGF2BP2-1155H Recombinant Human IGF2BP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IGF2BP2-5805HF Recombinant Full Length Human IGF2BP2 Protein, GST-tagged In Vitro Cell Free System GST 598 amino acids
Human IGF2BP2-5150H Recombinant Human IGF2BP2 Protein, GST-tagged Wheat Germ GST
Human IGF2BP2-2619H Recombinant Human IGF2BP2 Protein (Ser141-Pro384), N-His tagged E.coli N-His Ser141-Pro384
Human IGF2BP2-1396H Recombinant Human IGF2BP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse IGF2BP2-8067M Recombinant Mouse IGF2BP2 Protein Mammalian Cell His
Mouse Igf2bp2-1863M Recombinant Mouse Igf2bp2 protein, His & T7-tagged E.coli His/T7 Ile293~His557 (Accession # Q5SF07)
Mouse IGF2BP2-4463M-B Recombinant Mouse IGF2BP2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Igf2bp2-3489M Recombinant Mouse Igf2bp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IGF2BP2-4463M Recombinant Mouse IGF2BP2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IGF2BP2 Related Articles
  • IGF2BP2 Related Research Area

IGF2BP2 involved in several pathways and played different roles in them. We selected most pathways IGF2BP2 participated on our site, such as Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Gene ExpressionZNF625;SPCS3;USP9;ZNF544;EEF1B2;GTF3C5;XPOT;MYBL1;SNUPN
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNAIGF2BP3;IGF2BP1;IGF2BP2

IGF2BP2 has several biochemical functions, for example, mRNA 3-UTR binding, mRNA 5-UTR binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP2 itself. We selected most functions IGF2BP2 had, and list some proteins which have the same functions with IGF2BP2. You can find most of the proteins on our site.

Function Related Protein
mRNA 3-UTR bindingCPEB4;PUM2;RBMS3;RBM24;TES;YBX2;CSDA;TUT1;ELAVL1
mRNA 5-UTR bindingDDX3X;MRPS11;IGF2BP1;RPS14;LARP1;IGF2BP3;IGF2BP2
nucleotide bindingNCL;TDRD12;Fert2;ZNF143B;SMYHC1;NCBP2;CPEB3;ATP13A3;ENOX2
poly(A) RNA bindingRBM47;FKBP4;PPIL4;ALDOA;VCP;NOL11;PTCD1;PPIE;CASC3
protein bindingPVRL1;NXT2;TPPP;HPS4;MAVS;MFN2;MPP5;SPON1;NEU4
translation regulator activityAIRE;RPS9;RPS14;YBX2;IGF2BP3;IGF2BP2;IGF2BP1

IGF2BP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP2.

YBX1; MYC; HNRNPD; 38mer; CNBP; PUF60; GSTK1; HNRNPD; pta; ssrna_ug

Laggai, S; Kessler, SM; et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. JOURNAL OF LIPID RESEARCH 55:1087-1097(2014).
Salem, SD; Saif-Ali, R; et al. IGF2BP2 Alternative Variants Associated with Glutamic Acid Decarboxylase Antibodies Negative Diabetes in Malaysian Subjects. PLOS ONE 7:-(2012).
  • Q&As
  • Reviews

Q&As (0)

Ask a question

Customer Reviews (0)

Write a review

Ask a Question for All IGF2BP2 Products

Required fields are marked with *

My Review for All IGF2BP2 Products

Required fields are marked with *

logo

FOLLOW US

Terms and Conditions        Privacy Policy

Copyright © 2024 Creative BioMart. All Rights Reserved.

Contact Us

  • /

Stay Updated on the Latest Bioscience Trends