igf2bp2

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igf2bp2

Official Full Name Insulin-like growth factor 2 mRNA binding protein 2
Background Insulin-like growth factors (IGFs) regulate the proliferation, differentation, apoptose, cell adhesion and metabolism in various tissues and cell types. The IGF-I, which is produced mainly in liver under the influence of Growth Hormone (GH), regulates as hormone the linear growth of the bones and the process of sexual maturity, while IGF-II is mainly a growth factor of foetal tissue. The biological actions of IGF over the IGF-Type-I receptor are modulated variably through the IGF binding proteins (IGFBP-1 to-6). IGFBP-2 is, after IGFBP-3, the second most frequent IGFBP in the human blood. IGFs, especially tumor typical pro-IGF-forms and hormones regulate the expression of IGFBP-2, GH effect is thereby inhibiting. At cellular level IGFBP-2 seems to stimulate the proliferation and dissemination of solid tumors via an IGF-independent mechanism. IGFBP-2 is an unglycosylated polypetide of 31.3 kDa, which forms binary IGF-complexes and shows no circadian rhythm in the circulation. The serum concentration of IGFBP-2 increases in fasting, after major surgery and after trauma, but the increasing of the concentration is most intensive in malignant diseases. The correlation of the IGFBP-2 level to the degree of progression is a striking feature in various tumor types as is the normalization of the IGFBP-serum levels after remission. During the GH-therapy, e.g. in short stature and in GH-abuse (doping) the IGFBP-2 level decreases. In Trisomy 18 IGFBP-2 in maternal serum is decreased and IGFBP-1 is increased; therefore the ratio IGFBP-2 /IGFBP-1 is a marker for this chromosome abnormality. Transgenic organisms are a good opportunity to investigate the function of genes or proteins. The mouse model is a well-suited system for investigation of the relevance of IGFBP-2 in physiological and pathological processes. Over expression of the IGFBP-2 gene in mice results in a weight reduction of 30% in spleen and moderately reduced weight in other organs. Effects of IGFBP-2 on the organism can be compensated through the modified expression of other IGF-Binding proteins. Especially in tumor biology the mouse system enables investigation of the systemic relevance of IGFBP-2. IGFBP-2 influences tumor cells as it induces catalase activity in adrenocortical cells. Furthermore IGFBP-2 interacts with tumor cells via its RGD-amino acid sequence and seems to stimulate cell invasion of glioma cells.
Synonyms RP23-50H13.1; C330012H03Rik; IMP-2; Imp2; Neilsen; IGF-II mRNA-binding protein 2; IGF2 mRNA-binding protein 2; VICKZ family member 2; insulin-like growth factor 2 mRNA-binding protein 2; insulin-like growth factor 2, binding protein 2
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IGF2BP2-1390H Recombinant Human IGF2BP2 Protein, His/T7-tagged E.coli His/T7
    Human IGF2BP2-1396H Recombinant Human IGF2BP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IGF2BP2-1862H Recombinant Human IGF2BP2 protein, His & T7-tagged E.coli His/T7
    Human IGF2BP2-3874H Recombinant Human IGF2BP2, His & GST tagged Insect Cell His/GST
    Human IGF2BP2-5150H Recombinant Human IGF2BP2 Protein, GST-tagged Wheat Germ GST
    Human IGF2BP2-639HCL Recombinant Human IGF2BP2 cell lysate Insect Cell N/A
    Mouse Igf2bp2-1863M Recombinant Mouse Igf2bp2 protein, His & T7-tagged E.coli His/T7
    Mouse IGF2BP2-8067M Recombinant Mouse IGF2BP2 Protein Mammalian Cell His

    igf2bp2 involved in several pathways and played different roles in them. We selected most pathways igf2bp2 participated on our site, such as Gene Expression, Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with igf2bp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Gene Expression HNRNPL; MED16; TRIM33; ZNF620; NR2E1; SMG8; LSM11; ZNF490; ZNF184; SETA
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA IGF2BP1; IGF2BP2; IGF2BP3

    igf2bp2 has several biochemical functions, for example, mRNA 3-UTR binding, mRNA 5-UTR binding, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igf2bp2 itself. We selected most functions igf2bp2 had, and list some proteins which have the same functions with igf2bp2. You can find most of the proteins on our site.

    Function Related Protein
    mRNA 3-UTR binding TARDBP; CPEB1; CPEB2; RNF40; TES; ZNF385A; PUM2; ELAVL4; IGF2BP2; CARHSP1
    mRNA 5-UTR binding DDX3X; IGF2BP2; IGF2BP1; MRPS11; LARP1; IGF2BP3; RPS14
    nucleotide binding SETD1B; FPGS; SYNCRIP; HNRNPH1; LTK; SMC2; VDAC3; RPS6KAL; AKT2L; NT5C1A
    poly(A) RNA binding CHERP; SURF6; BCLAF1; FUBP3; U2SURP; FAM103A1; FAM50A; UBAP2; FAM98C; GM5506
    protein binding IGF2; IPO7; RGS16; WDR24; LIPT2; ZNF124; GET4; SPATA24; PRR3; CCDC13
    translation regulator activity IGF2BP1; RPS14; IGF2BP3; RPS9; IGF2BP2; YBX2; AIRE

    igf2bp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igf2bp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of igf2bp2.

    YBX1; MYC; HNRNPD; 38mer; CNBP; PUF60; GSTK1; HNRNPD; pta; ssrna_ug

    Laggai, S; Kessler, SM; et al. The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis. JOURNAL OF LIPID RESEARCH 55:1087-1097(2014).
    Salem, SD; Saif-Ali, R; et al. IGF2BP2 Alternative Variants Associated with Glutamic Acid Decarboxylase Antibodies Negative Diabetes in Malaysian Subjects. PLOS ONE 7:-(2012).

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