IL-8

Species Cat.# Product name Source (Host) Tag Protein Length Price
Cynomolgus IL-8-1023C Active Recombinant Cynomolgus IL-8 protein, His-tagged HEK293 His Ala 23 - Pro 101
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFSF12;TNFRSF9;CCL3L3;TGFB3;IL17RB;IFNPHI3;CD40;PRP2;CCL27
Chemokine signaling pathwayPIK3R3;RHOA;JAK2;VAV2;GM2506;CCL5;CCL28;GNAI1;CCL3
NF-kappa B signaling pathwayNFKB2;CCL4;CXCL2;IL1R1;IRAK4;SYK;TLR4;TRIM25;Bcl2a1b
Phospholipase D signaling pathwayDGKD;TSC2;PDGFA;GAB2;GRM2;SHC2;GRM1;PLCB2;INS2
Toll-like receptor signaling pathwayPIK3R5;MAP2K4B;CD14;TLR2-2;STAT1B;PIK3R3;MAPK12;MAP2K3;IFNA1
NOD-like receptor signaling pathwayMAPK14A;BIRC2;CASP5;CCL5;NFKBIA;SUGT1;NAIP1;HSP90B1;NFKBIAA
RIG-I-like receptor signaling pathwayMAPK10;TBK1;TANK;IFNE;NFKBIA;ATG12;IKBKE;SIKE1;NLRX1
Non-alcoholic fatty liver disease (NAFLD)SREBF1;Fasl;IKBKB;NDUFA3;MAPK10;PPARA;NDUFAB1;NFKB1;CEBPA
Epithelial cell signaling in Helicobacter pylori infectionATP6V1D;ATP6V1B2;MAPK8;PLCG2;ATP6V1B1;CDC42;JAM2;ATP6V0A2;CXCR1
ShigellosisU2AF1;MAPK1;RELA;ATG5;DIAPH1;MAPK3;IKBKG;MAPK13;ELMO1
Salmonella infectionCDC42;NOS2A;ARPC4L;IL-8;ARPC5LB;FOS;TLR5;ACTB;IL6
PertussisIL1B;TICAM2;MYD88;ITGB2;C3;CALM3;Itgam&Itgb2;CALM4;C4BPB
LegionellosisC3;CLK1;HSF1;SEC22B;EEF1A2;NFKBIA;EEF1A1;EEF1G;CASP7
Chagas disease (American trypanosomiasis)IL-8;MAPK12;SMAD2;PPP2R2C;TGFB2;IL1B;C3;MAPK1;PIK3R2
MalariaIFNG;TGFB3;SELE;CD81;MYD88;VCAM1;ITGAL;GYPB;ICAM1
AmoebiasisCXCL8;IL12A;PRKCB;PIK3CD;IL1R1;PIK3CB;PRKCA;IL12B;RAB7A
Hepatitis CARAF;MAPK10;OAS2;IFNA10;IFNAR2;KRAS;RNASEL;CLDN17;PPP2R2B
Hepatitis BAKT1;IL6;PIK3R5;MAP2K1;CASP10;BAX;TP53;PTEN;TLR4
Influenza AIFNB1;BLB2;HLA-DQB1;IFNAR1;TMPRSS4;IL6;ACTG1;NXF3;IRF9
Pathways in cancerRXRG;RALGDS;HGF;TGFB2;SOS1;LAMA4;KIT;AGTR1A;MMP2
Transcriptional misregulation in cancerPROM1;ETV1;PAX8;CD86;RUNX1T1;DEFA3;IGFBP3;JMJD1C;ELK4
Bladder cancerFGFR3;MDM2;RASSF1;NRAS;MYC;DAPK2;ERBB2;CCND1;MMP1
Rheumatoid arthritisATP6V1D;HLA-DRB3;ATP6V1G1;CCL3;TNFSF13;Il23a;IL23;TNFSF13B;ANGPT1

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.

Function Related Protein
chemokine activityXCL2;CCL35.1;CCL18;CCL26;CCL19B;CCL35.2;CCL39.1;CCL8;CCL33.2
interleukin-8 receptor bindingMADD;YARS;IL-8
protein bindingPOU3F2;DSTN;PGBD1;NCKIPSD;PCDHA4;Clec4n;SPATA13;IRF1;HSPD1

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.

CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3

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Customer Reviews (3)

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Reviews
06/24/2022

    Good stability in vivo.

    04/14/2020

      Can enhance the effectiveness of the body's immune response.

      12/26/2019

        It has high biological activity and stability.

        Q&As (6)

        Ask a question
        How relationship between IL-8 and inflammatory response? 07/22/2022

        It is a pro-inflammatory factor, which can promote neutrophils' chemotaxis and adhesion to inflammatory sites, thus participating in the inflammatory response process.

        What is the inflammatory response mechanism of IL-8? 05/19/2022

        IL-8 promotes chemotaxis and adhesion of neutrophils to inflammatory sites by acting on CXCR1 and CXCR2 receptors on the surface of neutrophils.

        Through which signaling pathways does IL-8 function? 08/08/2020

        Plays its role mainly through JNK, ERK, p38 and NF-κB signaling pathways.

        What is the relationship between IL-8 and other cytokines? 03/09/2020

        The relationship between IL-8 and other cytokines is complex, and it may interact with IL-6, TNF-α and other cytokines in inflammatory response.

        Are there have any clinical applications of IL-8? 10/06/2019

        Recombinant IL-8 protein can be used to treat certain inflammatory diseases. For example, it can be used to treat asthma, chronic obstructive pulmonary disease, and so on.

        Which application prospect of IL-8 in lung cancer treatment? 09/15/2019

        It may have a certain application prospect in the treatment of lung cancer, which can be treated by regulating tumor microenvironment and promoting immune response.

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