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How relationship between IL-8 and inflammatory response?
It is a pro-inflammatory factor, which can promote neutrophils' chemotaxis and adhesion to inflammatory sites, thus participating in the inflammatory response process.
What is the inflammatory response mechanism of IL-8?
IL-8 promotes chemotaxis and adhesion of neutrophils to inflammatory sites by acting on CXCR1 and CXCR2 receptors on the surface of neutrophils.
Through which signaling pathways does IL-8 function?
Plays its role mainly through JNK, ERK, p38 and NF-κB signaling pathways.
What is the relationship between IL-8 and other cytokines?
The relationship between IL-8 and other cytokines is complex, and it may interact with IL-6, TNF-α and other cytokines in inflammatory response.
Are there have any clinical applications of IL-8?
Recombinant IL-8 protein can be used to treat certain inflammatory diseases. For example, it can be used to treat asthma, chronic obstructive pulmonary disease, and so on.
Which application prospect of IL-8 in lung cancer treatment?
It may have a certain application prospect in the treatment of lung cancer, which can be treated by regulating tumor microenvironment and promoting immune response.