IL-8
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Cynomolgus | IL-8-1023C | Active Recombinant Cynomolgus IL-8 protein, His-tagged | HEK293 | His | Ala 23 - Pro 101 |
|
- Involved Pathway
- Protein Function
- Interacting Protein
- IL-8 Related Research Area
IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | TNFRSF1A;FAS;CXCL2;Flt3l;Ccl9;IL12B;BMPR1BA;HGF;Ccl21c |
| Chemokine signaling pathway | RLN1;Ccl21a;RAP1B;RAF1;CRKL;CCR1;XCR1;Ccl9;CCL11 |
| NF-kappa B signaling pathway | TNFSF11;IKBKB;LYN;TNFRSF13C;CCL13;PLCG1;VCAM1;MAP3K14;IKBKG |
| Phospholipase D signaling pathway | GNAS;PPAP2B;CYTH4;LPAR4;PLCG2;AVPR2;FYN;GRM5;LPAR3 |
| Toll-like receptor signaling pathway | STAT1;MAPK8B;IFNA6;TLR5B;TOLLIP;RAC1;MAPK13;TLR9;TLR3 |
| NOD-like receptor signaling pathway | NLRP1;MAP3K7IP3;NFKB1;MAP3K7;NFKBIA;CASP5;MAPK9;MAPK1;IL18 |
| RIG-I-like receptor signaling pathway | NT5C3;TANK;IKBKE;MAVS;IFNA5;IFIH1;IFNB1;IKBKG;AZI2 |
| Non-alcoholic fatty liver disease (NAFLD) | CASP8;ADIPOR1;MLXIPL;INS1;COX7A2;MAPK9;SDHA;ERN1;PRKAA1 |
| Epithelial cell signaling in Helicobacter pylori infection | ATP6V1E2;TJP1;TCIRG1;CDC42;RELA;MAPK10;ADAM17;ATP6V0B;MAPK9 |
| Shigellosis | ITGB1;PFN4;ARPC5L;MAPK8;WAS;CDC42;IL-8;WASF1;MAPK9 |
| Salmonella infection | MYD88;NOS2;KLC1B;IL1B;ACTB1;PFN2L;PFN3;ARPC5LA;MAPK12 |
| Pertussis | C1QA;CFL2;CASP7;IL6;RELA;IL-8;C3;IRAK4;ITGB2 |
| Legionellosis | NFKBIA;CD14;NFKB2;SAR1A;SEC22B;TLR4;ITGB2L;CASP1;IL18 |
| Chagas disease (American trypanosomiasis) | CXCL8;PPP2R2B;TNF;PIK3R3;MAPK11;IFNB1;BDKRB2;PIK3R5;CD3E; CD3D |
| Malaria | KLRC4-KLRK1;IFNG;CD40;HBB-B1;CD81;TLR4;HBB-B2;HBA1;THBS4 |
| Amoebiasis | IL1B2;COL24A1;C9;CD14;IL-8;PIK3CD;SERPINB3C;PIK3CB;ACTN3 |
| Hepatitis C | AKT2;PPP2CA;CXCL8;RXRA;GRB2;STAT3;MAPK11;IFNA8;TP53 |
| Hepatitis B | MYD88;TBK1;IFNA13;TLR2;FASLG;NFATC3;CCND1;STAT5B;TGFBR1 |
| Influenza A | HLA-DQB1;TLR7;NFKBIA;TRIM25;IFNA2;NXF3;AKT2;AGFG1;IL33 |
| Pathways in cancer | F2RL3;GNG13;IKBKB;IL6;SMAD4;XIAP;PIK3CG;BAD;PGF |
| Transcriptional misregulation in cancer | MAX;CD40;CDK14;SP1;HIST2H3C1;ZBTB17;ASPSCR1;MDM2;ITGAM |
| Bladder cancer | MDM2;CDKN2A;TRP53;MAPK1;CCND1;RB1;MAP2K1;TP53;E2F1 |
| Rheumatoid arthritis | TGFB1;MMP1;HLA-DMB;IFNG;ATP6V0D1;IL1B;CXCL5;LTB;IL18 |
IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine activity | CCL13;CCL34A.4;PPBP;CCL3L1;CCL19A.1;CCL44;PF4V1;CCL38A.4;XCL2 |
| interleukin-8 receptor binding | MADD;YARS;IL-8 |
| protein binding | APBB2;SPRR1A;FAM71C;CD93;TTYH2;SPHK2;RFX3;ZNF514;ARPIN |
IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3
- Q&As
- Reviews
Q&As (6)
Ask a questionIt is a pro-inflammatory factor, which can promote neutrophils' chemotaxis and adhesion to inflammatory sites, thus participating in the inflammatory response process.
IL-8 promotes chemotaxis and adhesion of neutrophils to inflammatory sites by acting on CXCR1 and CXCR2 receptors on the surface of neutrophils.
Plays its role mainly through JNK, ERK, p38 and NF-κB signaling pathways.
The relationship between IL-8 and other cytokines is complex, and it may interact with IL-6, TNF-α and other cytokines in inflammatory response.
Recombinant IL-8 protein can be used to treat certain inflammatory diseases. For example, it can be used to treat asthma, chronic obstructive pulmonary disease, and so on.
It may have a certain application prospect in the treatment of lung cancer, which can be treated by regulating tumor microenvironment and promoting immune response.
Customer Reviews (3)
Write a reviewGood stability in vivo.
Can enhance the effectiveness of the body's immune response.
It has high biological activity and stability.
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