il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IRX1; IL17A; IL2RGB; CXCL2; NT5C3; VEGFAA; CSF1RA; CRFB16; BMPR1AA; PRLR
Chemokine signaling pathway
CX3CR1; FOXO3; PREX1; ADRBK2; CCL24; STAT3; VAV1; IL-8; CXCL12; CXCL3
NF-kappa B signaling pathway
LRDD; LBP; LTBR; CCL4; SYK; PLAU; XIAP; TRAF6; PRKCB; LTB
Phospholipase D signaling pathway
RALGDS; Pdgfa&Pdgfb; PLA2G4D; PIK3CG; LPAR2; AGPAT4; MS4A2; Kitl; HRAS; NRAS
Toll-like receptor signaling pathway
MAPK8; RIPK1L; IFNA4; CXCL11; PIK3CG; LY96; FADD; IL12B; IL12A; CCL3L1
NOD-like receptor signaling pathway
PSTPIP1B; TNF; MAPK12B; MAPK3; HSP90B1; NAIP6; MAPK14A; HSP90AA1.2; MAPK12; NFKBIB
RIG-I-like receptor signaling pathway
TRAF6; CASP10; IFIH1; MAPK8B; RNF207B; TBK1; MAPK12A; MAPK8; IRF3; MAPK8A
Non-alcoholic fatty liver disease (NAFLD)
NDUFS5; CEBPA; NDUFB1; PIK3R1; AKT1; NDUFB3; COX7B; COX7A2L; NDUFS7; ADIPOR1
Epithelial cell signaling in Helicobacter pylori infection
MAP2K4; ATP6V1B1; IL-8; ATP6V1E2; PLCG2; NOD1; LYN; PTPN11; TJP1; MAPK10
Shigellosis
CDC42; ABL1; ATG5; RIPK2; IKBKB; ROCK1; MAPK10; NFKB1; RAC1; FBXW11
Salmonella infection
PKN3; FLNA; TLR4BA; CCL4; CXCL8B.3; DYNC1LI2; MAPK1; IFNGR2; ARPC5A; IFNG
Pertussis
NLRP3; IL6; RELA; C4BPA; RHOA; MAPK11; CALML3; C3; C1S; IRF8
Legionellosis
APAF1; NFKB2; BNIP3; IL12A; TLR4; IL6; MYD88; ITGB2L; IL1B; Casp3
Chagas disease (American trypanosomiasis)
TLR6; PPP2R2B; C1QC; CCL3; SMAD3; PPP2R2D; IFNG; PPP2CB; TNFRSF1A; TGFBR2
Malaria
SDC1; ICAM1; HBB; CCL2; ITGB2; Ccl12; TLR2; GYPA; TNF; GYPC
Amoebiasis
ITGB2; COL2A1; GNAL; LAMA1; LAMA3; LAMC1; COL5A1; LAMC2; ITGAM; CSF2
Hepatitis C
IFNA6; RIPK1; PIK3R5; TRAF3; CLDN1; CLDN14; MAPK8; CLDN3; TLR3; CLDN6
Hepatitis B
EGR2; PIK3CD; MAPK3; PIK3R5; CCNA1; PCNA; MAPK1; MMP9; CREB3L3; AKT2
Influenza A
TBK1; IL1A; PIK3R2; ACTB; RAE1; IFNA1; MAP2K4; IFNA7; TLR7; BLB2
Pathways in cancer
PIK3CB; FGF18; PPARG; RUNX1T1; Ar; CDC42; CCDC6; LAMA5; LAMC1; PTGER1
Transcriptional misregulation in cancer
MLF1; MLLT1; FLI1; HDAC2; JMJD1C; HIST1H3A; HIST1H3C; PROM1; RUNX1; LDB1
Bladder cancer
NRAS; E2F3; ERBB2; RASSF1; MAPK3; MMP9; MAP2K2; THBS1; EGF; E2F1
Rheumatoid arthritis
ATP6V1C2; HLA-DPA1; ATP6V0E; ATP6V1G2; H2-AB1; FLT1; TNFSF11; HLA-DRB1; HLA-DRB4; Ctsl

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CCL18; Ccl21c; CCL38A.5; CCL4; CCL5; CKLF; XCL1; CXCL5; CCL3L1; CXCL11.8
Function interleukin-8 receptor binding
Related Protein YARS; MADD; IL-8
Function protein binding
Related Protein TRAFD1; RUSC2; AGBL4; RNF135; MGST1; SOCS7; SULT1A1; CD8B1; PIK3IP1; SPATA13

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3