il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
CXCR1; GM-CSF; LEPR; CXCL13; IL2RGA; Ifna15; TNFRSF21; TP-1; IL21R; CXCR2
Chemokine signaling pathway
GNB3; GNG13; STAT3; RELA; IKBKG; GNAI3; PARD3; GNG12; GRK1; CXCL2
NF-kappa B signaling pathway
XIAP; PLCG1; IRAK1; ZAP70; LRDD; RELA; Ccl21a; BIRC2; TNFAIP3; BCL2A1
Phospholipase D signaling pathway
PTGFR; PDGFRB; DGKE; Pdgfa&Pdgfb; GRM6; PIP5K1C; PRKCA; CXCR2; PIK3R5; RALB
Toll-like receptor signaling pathway
TRAF3; IFNB1; NFKBIAA; NFKBIA; STAT1B; MAP2K4A; IL12A; IFNA13; TMED7-TICAM2; TLR7
NOD-like receptor signaling pathway
MAPK3; TAB2; PSTPIP1B; MAPK9; SUGT1; NFKBIAB; IL6; CXCL1; IKBKG; CXCL2
RIG-I-like receptor signaling pathway
MAPK13; RNF207B; IFNA21; IFNA6; IKBKB; NLRX1; TP-1; MAPK8A; IL12B; MAP3K7
Non-alcoholic fatty liver disease (NAFLD)
NDUFB4; NDUFA3; SDHA; NDUFB7; TNF; IL1A; AKT2; INS1; MAPK10; UQCR10
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1H; NFKB1; CCL5; PAK1; SRC; ATP6V1D; ATP6V1A; CXCR1; ATP6V1E2; MAPK9
Shigellosis
PFN4; PFN2; MAPK1; IKBKB; WAS; CDC42; MAPK10; ITGA5; NFKBIB; ROCK2
Salmonella infection
ACTG1; MAPK3; WASF1; IFNG; IFNGR2; NOS2; MAPK8; TLR5B; CXCL2; CCL4
Pertussis
C5; C1R; CXCL5; IRF3; MAPK13; PYCARD; C4BPA; MYD88; MAPK9; Casp3
Legionellosis
HSPA1B; NAIP6; NFKBIA; ITGB2; EEF1A2; CASP8; IL1B; Itgam&Itgb2; IL-8; TLR2
Chagas disease (American trypanosomiasis)
IKBKG; GNAI2; PIK3CG; CFLAR; AKT1; TLR2; PPP2CA; ACE; C3; MAPK3
Malaria
VCAM1; IFNG; CCL2; TGFB2; HBB-B1; HBB-B2; ITGB2L; Ccl12; IL6; MYD88
Amoebiasis
SERPINB10; COL4A1; ITGB2L; COL1A2; PIK3R3; IL10; SERPINB3C; IL1R2; CXCL8; C8A
Hepatitis C
CLDN3; IRF3; CLDN22; LDLR; IFNA5; IFNA16; NFKBIA; PPP2R2B; PIK3CB; IFNA8
Hepatitis B
OSTN; PTK2B; FAS; IKBKE; RB1; PIK3R2; TRP53; TLR4; MAP2K1; YWHAZ
Influenza A
IFNA6; OAS1; LOC100033925; MAP2K3; IFNAR1; IFIH1; IFNAR2; PLG; EIF2AK4; GSK3B
Pathways in cancer
BIRC2; FGF16; PLCG1; PIK3R5; FGF6; CUL2; GNGT2; TP53; WNT8A; COL4A1
Transcriptional misregulation in cancer
ERG; H3F3A; RXRA; PTCRA; H3F3B; MLLT3; ITGB7; SSX2; RXRG; CCND2
Bladder cancer
CDKN2A; MMP1A; MAPK3; HRAS; MMP1; CDK4; E2F1; CXCL8; DAPK1; VEGFA
Rheumatoid arthritis
IL23; ATP6V0D1; ATP6AP1; FOS; CD86; HLA-DPA1; CD28; HLA-DRB5; ATP6V1C2; TNFRSF11A

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein IL8L2; CCL35.1; Cxcl15; CXCL20; CCL35.2; CCL16; CCL5; CCL33.3; CCL21B; CCL27B
Function interleukin-8 receptor binding
Related Protein MADD; IL-8; YARS
Function protein binding
Related Protein GAK; CRYBA1; NOS3; TAPBP; PADI4; ZNF496; CLN5; PLEKHG2; MOV10; IRAK4

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3