il-8
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  • Official Full Name
  • Synonyms

Involved Pathway

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
LEPR; KIT; Il23a; Il12b; IL3; ACVR2AA; MET; CD40LG; IL20; IL17A; ACVR1B
Chemokine signaling pathway
HCK; CCL13; PRKCD; PTK2B; NCF1; PRKACG; RELA; Ccl21c; GNAI3; CCL20
NF-kappa B signaling pathway
PRKCB; NFKB1; CARD11; MAP3K7; CD14; CCL21; CXCL2; UBE2I; IL1R1; LTA
Phospholipase D signaling pathway
RAF1; AGTR1B; AVPR1B; AGTR1A; PLD1; RALB; CYTH2; PIK3R2; LPAR6; GRM4
Toll-like receptor signaling pathway
TRAF6; TLR1LA; PIK3R3B; CD86; FOS; CCL4L2; AKT2; CCL3; IFNAR1; MAPK14B
NOD-like receptor signaling pathway
LOC100033925; MAPK12A; CXCL8B.3; MAPK14A; IKBKG; MAP3K7; PYCARD; NFKBIAB; Ccl12; CARD18
RIG-I-like receptor signaling pathway
RIPK1; IFNA7; IFNE; IL-8; PL10; IFNPHI3; IFNB1; RELA; DDX3X; MAP3K7
Non-alcoholic fatty liver disease (NAFLD)
MAPK10; PRKAG2; LEP; UQCRC1; NDUFB2; NDUFV3; ADIPOR1; INSR; SOCS3; NDUFB5
Epithelial cell signaling in Helicobacter pylori infection
ATP6V1G3; ATP6V0D1; NFKB1; MAPK11; IKBKG; MET; ATP6V1C1; PLCG2; ATP6V1E1; TCIRG1
Shigellosis
MAPK3; RHOG; MAPK9; MAPK10; ATG5; PFN2; ELMO3; ACTB; MAPK8; MAD2L2
Salmonella infection
IL18; MAPK14B; CASPA; WASLA; WAS; KLC1A; ROCK2A; IFNGR2; ACTG1; MAPK13
Pertussis
CXCL6; C1S; NLRP3; Il23a; Il12b; GNAI1; ITGAM; CALM3; C4A; MAPK11; ITGA5
Legionellosis
HSPA2; Itgam&Itgb2; HSPA8; CR1; IL-8; ITGB2; RAB1B; Casp3; IL6; HSPA1B
Chagas disease (American trypanosomiasis)
GNAQ; PPP2R1A; MAPK11; CCL2; CCL3; CASP8; PPP2R2D; MAP2K4; NOS2; PIK3CD
Malaria
SELE; HBA2; KLRC4-KLRK1; HBB-B1; IL18; TNF; TGFB2; SDC2; MET; HBA1
Amoebiasis
SERPINB4; COL4A3; LAMC3; IL1R2; NOS2; IL12B; PLCB4; COL4A6; PRKCG; COL27A1
Hepatitis C
CXCL8; NFKBIA; PPP2R2C; IFNA7; KRAS; IFNA10; EIF2AK2; TNF; RXRA; MAPK8
Hepatitis B
Ifna11; IFNA1; BCL2; IFNA14; MAP3K1; PCNA; BAX; IFN-a; YWHAZ; TLR3
Influenza A
GSK3B; HSPA6; IFNA12; MAP2K3; PRSS3; NFKB1; VDAC1; HLA-DPB1; NFKBIA; TLR4
Pathways in cancer
BCR; STAT5B; MITF; ITGA2B; KIT; FGF5; LAMA1; FZD7; RXRB; NFKB2
Transcriptional misregulation in cancer
EWSR1; NGFR; FCGR1A; MLLT3; MEF2C; ETV5; MEN1; BCL6; FOXO1; FCGR1
Bladder cancer
CDKN2A; TP53; RB1; RAF1; MMP1; MMP1A; UPK3A; VEGFA; DAPK3; CCND1
Rheumatoid arthritis
ICAM1; ATP6V1G1; TLR2; ATP6V0D2; HLA-DQA1; HLA-DRA; ATP6V0A1; ATP6AP1; FOS; LTB

Protein Function

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.
Function
Related Protein
Function chemokine activity
Related Protein CCL34A.4; CXCL6; CCL23; CCL35.1; CCL20B; CCL16; CCL38.1; PF4; Ccl12; CXCL32B.1
Function interleukin-8 receptor binding
Related Protein IL-8; MADD; YARS
Function protein binding
Related Protein TBX5A; BTRC; DAO; pab1; GORAB; CPEB3; IRAK1; C16orf45; SERPINB5; CD2

Interacting Protein

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.
CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3