IL-8

Species Cat.# Product name Source (Host) Tag Protein Length Price
Cynomolgus IL-8-1023C Active Recombinant Cynomolgus IL-8 protein, His-tagged HEK293 His Ala 23 - Pro 101
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL-8 Related Research Area

IL-8 involved in several pathways and played different roles in them. We selected most pathways IL-8 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL-8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionFIGF;TNFRSF10B;CCL4L2;CXCR4A;ACVR1;TNFRSF9;CXCL10;CCR9;CXCR6
Chemokine signaling pathwayGNAI2;RHOA;GRK4;GRK5;Ccl21c;GSK3A;ROCK2;CCL20;CRKL
NF-kappa B signaling pathwayNFKB2;CXCL2;Bcl2a1b;IL1B;LAT;PTGS2;Ccl21a;CCL21B;TNFRSF13C
Phospholipase D signaling pathwayINS1;AKT1;PRKCA;GRM6;PIK3CA;PIK3R1;GRM7;CYTH3;FCER1A
Toll-like receptor signaling pathwayTLR2;TRAF3;AKT1;CCL3;RAC1B;IFNB;AKT3A;MAP2K3;CCL5
NOD-like receptor signaling pathwayMAPK1;MAPK8;CARD8;PSTPIP1B;NFKBIAA;MAPK12B;NFKBIAB;PYDC1;BIRC3
RIG-I-like receptor signaling pathwayTANK;MAPK14A;IFNA5;TNF;TRAF2;DAK;DDX3;TRAF6;IFNA4
Non-alcoholic fatty liver disease (NAFLD)NDUFB2;GSK3B;SDHB;RELA;ATF4;CDC42;COX6A2;UQCRC2;PIK3CG
Epithelial cell signaling in Helicobacter pylori infectionMAPK13;ATP6V1H;ATP6V0A2;ATP6V1B2;MAPK8;ATP6V1E1;JAM2;CXCL1;PLCG2
ShigellosisACTB;MAPK11;MAPK10;ELMO2;ARPC5L;SRC;PFN2;CDC42;ELMO1
Salmonella infectionFLNA;ROCK2A;FOS;ACTB1;RILP;CCL4;TLR4BB;DYNC1I2A;MAPK12
PertussisITGB1;Itgam&Itgb2;IL1A;ITGAM;IL12A;CALM3;IL-8;ITGA5;TLR4
LegionellosisITGB2;CASP1;CXCL2;RAB1A;IL18;VCP;TLR4;RELA;BCL2L13
Chagas disease (American trypanosomiasis)TNFRSF1A;TGFB2;PPP2R2C;CD247;Fasl;Il2;GNAI1;SMAD2;CD3D
MalariaSDC2;IL12A;CD40LG;LRP1;TLR2;ITGB2L;HBB;KLRB1;THBS3
AmoebiasisPTK2;PLCB1;COL4A4;IL1R2;IL1R1;IFNG;ITGB2;SERPINB1A;ITGAM
Hepatitis CLDLR;OCLN;PPARA;BAD;IFNA7;EIF2AK1;MAPK3;CLDN17;CLDN16
Hepatitis BMAP2K4;IFN-a;IFNA14;AKT2;FOS;Ifna11;IRF3;IKBKE;YWHAB
Influenza AICAM1;Ccl12;CASP9;NXT2;MAP2K7;TLR3;ACTB;MAPK8;PLG
Pathways in cancerLAMB1;FAS;BMP4;RAC1;BAX;ROCK2;LPAR5;FZD3;GNA11
Transcriptional misregulation in cancerAff1;PML;IL6;CD86;NR4A3;ETV7;HOXA10;SIX1;ETV4
Bladder cancerE2F1;BRAF;EGF;UPK3A;MMP1;HRAS;DAPK3;MMP1A;FGFR3
Rheumatoid arthritisTNFRSF11A;ATP6V0D1;MMP3;Ccl12;CCL3L3;Ctsl;CD80;CD28;HLA-DQA2

IL-8 has several biochemical functions, for example, chemokine activity, interleukin-8 receptor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL-8 itself. We selected most functions IL-8 had, and list some proteins which have the same functions with IL-8. You can find most of the proteins on our site.

Function Related Protein
chemokine activityCCL38A.5;CCL26;CXCL14;CCL20;Ccl21c;CXL34B.11;CCL35.1;CCL7;PF4
interleukin-8 receptor bindingYARS;MADD;IL-8
protein bindingTAF13;SH3BP4;TPPP;CSF1;LIG3;B2M;DDC;ASAP3;ARMCX1

IL-8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL-8 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL-8.

CXCR2; SGTA; BAG6; POMGNT1; ARFGAP3

  • Q&As
  • Reviews

Q&As (6)

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How relationship between IL-8 and inflammatory response? 07/22/2022

It is a pro-inflammatory factor, which can promote neutrophils' chemotaxis and adhesion to inflammatory sites, thus participating in the inflammatory response process.

What is the inflammatory response mechanism of IL-8? 05/19/2022

IL-8 promotes chemotaxis and adhesion of neutrophils to inflammatory sites by acting on CXCR1 and CXCR2 receptors on the surface of neutrophils.

Through which signaling pathways does IL-8 function? 08/08/2020

Plays its role mainly through JNK, ERK, p38 and NF-κB signaling pathways.

What is the relationship between IL-8 and other cytokines? 03/09/2020

The relationship between IL-8 and other cytokines is complex, and it may interact with IL-6, TNF-α and other cytokines in inflammatory response.

Are there have any clinical applications of IL-8? 10/06/2019

Recombinant IL-8 protein can be used to treat certain inflammatory diseases. For example, it can be used to treat asthma, chronic obstructive pulmonary disease, and so on.

Which application prospect of IL-8 in lung cancer treatment? 09/15/2019

It may have a certain application prospect in the treatment of lung cancer, which can be treated by regulating tumor microenvironment and promoting immune response.

Customer Reviews (3)

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Reviews
06/24/2022

    Good stability in vivo.

    04/14/2020

      Can enhance the effectiveness of the body's immune response.

      12/26/2019

        It has high biological activity and stability.

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