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ITPR2

  • Official Full Name

    inositol 1,4,5-trisphosphate receptor, type 2

  • Synonyms

    ITPR2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5 triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; IP3R2; 4; 5-trisphosphate receptor; Inositol 1 4 5 trisphosphate receptor type 2; Inositol 145 trisphosphate receptor type 2; InsP3 R2; InsP3R2; IP3 R2; IP3 receptor isoform 2; IP3R 2; ITPR 2; ITPR2_HUMAN; Type 2 inositol 1 4 5 trisphosphate receptor; Type 2 inositol 1; Type 2 inositol 145 trisphosphate receptor; Type 2 InsP3 receptor; IP3 receptor; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ITPR2-463H Recombinant Human ITPR2 Mammalian Cell His
Human ITPR2-3180H-B Recombinant Human ITPR2 Protein Pre-coupled Magnetic Beads HEK293
Human ITPR2-2347H Recombinant Human ITPR2 Protein, His-tagged E.coli N-His Met1-Val287
Human ITPR2-3180H Recombinant Human ITPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ITPR2-3126R Recombinant Rat ITPR2 Protein Mammalian Cell His
Rat ITPR2-2782R-B Recombinant Rat ITPR2 Protein Pre-coupled Magnetic Beads HEK293
Rat ITPR2-2782R Recombinant Rat ITPR2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ITPR2 Related Articles

ITPR2 involved in several pathways and played different roles in them. We selected most pathways ITPR2 participated on our site, such as Adaptive Immune System, Aldosterone synthesis and secretion, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemASB7;RNF182;IGKV1-5;IGLC2;FGFR1B;SPSB2;TPP2;SEC23A;GM11711
Aldosterone synthesis and secretionITPR2;SCARB1;PRKCB;CALM3;CAMK1D;ATF6B;CYP11A1;CREB3L4;CREB3L2
Alzheimers diseaseNDUFA13;NDUFS1;CASP9;APBB1;SDHC;NDUFA4;Atp5g2;NDUFS8;NCSTN
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersPIK3AP1;IGKC;STIM1B;IGKV1-5;IGHM;AHCYL1;SRMS;AKR1C1;BLK
B Cell Receptor Signaling PathwayDOK1;cgr2b;NFATC2;LYN;AKT1;IFITM1;GSK3B;HDAC5;MALT1
Beta-catenin independent WNT signalingAP2B1;CLTB;MOV10;ITPR2;DVL3;CLTC;ROR1;AP2A1;ROR2
C-type lectin receptors (CLRs)TAB1;CLEC4A;UBE2V1;CLEC4D;CREBBP;ITPR2;AHCYL1;CLEC6A;MALT1

ITPR2 has several biochemical functions, for example, calcium ion transmembrane transporter activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity, phosphatidylinositol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR2 itself. We selected most functions ITPR2 had, and list some proteins which have the same functions with ITPR2. You can find most of the proteins on our site.

Function Related Protein
calcium ion transmembrane transporter activity
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityITPR1;AKR1C1;ITPR3;ITPR2
phosphatidylinositol bindingSNX15;SNX32;NISCH;SNX9B;HIP1RB;SNX1A;PIK3C2A;TULP4;SNX8

ITPR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR2.

TRPC4; q81ye8_bacan; MYH9; CAPZA2; NUP107; Lima1; Myo1c; Sumo3

Zhang, ZJ; Tian, JL; et al. The Analysis of Expression of CCK and IP3 Receptors in Gallstones Patients with Type 2 Diabetes Mellitus. HEPATO-GASTROENTEROLOGY 61:2173-2176(2014).
Wang, JB; Wang, DL; et al. Tumor necrosis factor-alpha-induced reduction of glomerular filtration rate in rats with fulminant hepatic failure. LABORATORY INVESTIGATION 94:740-751(2014).
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