Recombinant Human ITPR2 Protein, His-tagged

• Cat.No.: ITPR2-2347H
• Product Overview: Recombinant Human ITPR2 Protein (Met1-Val287) with a N-His tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 36.2 kDa
  Accurate Molecular Mass: 38 kDa
• Protein length: Met1-Val287
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 [ Homo sapiens (human) ]
• Official Symbol: ITPR2
• Synonyms: ITPR2; inositol 1,4,5-trisphosphate receptor, type 2; inositol 1,4,5 triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; IP3R2; IP3R 2; insP3R2; IP3 receptor; type 2 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor
• Gene ID: 3709
• mRNA Refseq: NM_002223
• Protein Refseq: NP_002214
• MIM: 600144
• UniProt ID: Q14571