KCNQ2

  • Official Full Name

    potassium voltage-gated channel, KQT-like subfamily, member 2

  • Overview

    The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

  • Synonyms

    KCNQ2;potassium voltage-gated channel, KQT-like subfamily, member 2;EBN;BFNC;EBN1;ENB1;BFNS1;EIEE7;HNSPC;KV7.2;KCNA11;KVEBN1;potassium voltage-gated channel subfamily KQT member 2;KQT-like 2;voltage-gated potassium channel subunit Kv7.2;neuroblastoma-specific potassium channel protein;neuroblastoma-specific potassium channel subunit alpha KvLQT2
Cat.# Product name Source (Host) Species Tag Protein Length Price
KCNQ2-3222R Recombinant Rat KCNQ2 Protein Mammalian Cells Rat His
KCNQ2-5019HCL Recombinant Human KCNQ2 293 Cell Lysate HEK293 Human Non
KCNQ2-2878R Recombinant Rat KCNQ2 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
KCNQ2-2878R-B Recombinant Rat KCNQ2 Protein Pre-coupled Magnetic Beads HEK293 Rat
KCNQ2-301222H Recombinant Human KCNQ2 protein, GST-tagged E.coli Human GST Met1-Leu81

    Involved Pathway

    KCNQ2 involved in several pathways and played different roles in them. We selected most pathways KCNQ2 participated on our site, such as Axon guidance,Cholinergic synapse,Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KCNQ2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Interaction between L1 and Ankyrins NADL1.1,ANK2B,KCNQ3,SCN2B,SCN9A,SCN4A,SCN8A,SCN3A,SCN2A,SCN3B
    Potassium Channels KCNK7,KCND1,KCNG4A,KCNH1B,KCNN1B,KCNS3A,KCNQ2A,KCNJ1A.5,KCNK6,DDX1
    Neuronal System ABCC9,PPFIA2,KCNQ2A,KCNK7,MYO6,SNAP25A,KCNK6,KCNK18,CACNG2B,KCNK13A
    Cholinergic synapse KCNQ1,NRAS,CHRNA7,CAMK4,CREB3L4,CAMK2A,GNAI1,AKT1,PLCB1,GNB1
    Developmental Biology EFNB3B,EFNB2,DNM1,PAK4,MED6,SCN9A,LGI2A,EPHB3A,JAK3,CLASP1
    Voltage gated Potassium channels KCNH6,KCNG3,KCNA5,KCNAB1,KCNB2,KCNA10,KCNV2,KCNF1A,KCNQ3,KCNH1
    L1CAM interactions CD24,DPYSL2B,KIF4,DPYSL2,RANBP9,DLG3,CHL1,NRP1A,KCNQ3,NRP2
    Axon guidance FRS3,EPHB2,CHL1,FRS2A,RHOC,PTPRA,CLTB,KALRN,COL4A4,RGMA

    Protein Function

    KCNQ2 has several biochemical functions, for example, ankyrin binding,delayed rectifier potassium channel activity,potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KCNQ2 itself. We selected most functions KCNQ2 had, and list some proteins which have the same functions with KCNQ2. You can find most of the proteins on our site.

    Function Related Protein
    potassium channel activity KCNC2,KCNIP4,KCNK5A,KCNC3A,KCNC1B,KCNK7,KCNK10B,KCNS3A,KCNK3A,KCNH6A
    ankyrin binding SLC4A1,SLC8A1,FLNC,RHBG,PTBP3,SCN5A,CDH1,RHAG,NRCAM,RHCG
    delayed rectifier potassium channel activity KCNQ5,KCNG4A,KCNQ2A,KCNH1,KCNQ3,KCNA10,KCNF1A,KCNA1,KCNA5,KCNB2
    protein N-terminus binding DAXX,NBN,STX5A,SDCBP,EXOC5,RPS21,TSC1,SMARCE1,GTF2H2,HESX1
    voltage-gated potassium channel activity KCNH1B,KCNA1,HCN4,KCNV2B,CNGA1,KCNQ5,KCNH2A,KCNQ1,KCNA2,KCNE4

    Interacting Protein

    KCNQ2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KCNQ2 here. Most of them are supplied by our site. Hope this information will be useful for your research of KCNQ2.

    ARIH2

    Resources

    References

    • Bocksteins, E; Van de Vijver, G; et al. K(v)3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C406-C415(2012).
    • Pulkes, T; Dejthevaporn, C; et al. Paroxysmal neuromyotonia: A new sporadic channelopathy. NEUROMUSCULAR DISORDERS 22:479-482(2012).

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