kcnq2 Protein, potassium voltage-gated channel, KQT-like subfamily, member 2

kcnq2

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kcnq2

Official Full Name potassium voltage-gated channel, KQT-like subfamily, member 2
Background The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms KCNQ2; potassium voltage-gated channel, KQT-like subfamily, member 2; EBN; BFNC; EBN1; ENB1; BFNS1; EIEE7; HNSPC; KV7.2; KCNA11; KVEBN1; potassium voltage-gated channel subfamily KQT member 2; KQT-like 2; voltage-gated potassium channel subunit Kv7.2; neuroblastoma-specific potassium channel protein; neuroblastoma-specific potassium channel subunit alpha KvLQT2;
    • Species :
    • Human
    • Rat
    • Source :
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KCNQ2-5019HCL Recombinant Human KCNQ2 293 Cell Lysate HEK293 N/A
    Rat KCNQ2-3222R Recombinant Rat KCNQ2 Protein Mammalian Cell His

    kcnq2 involved in several pathways and played different roles in them. We selected most pathways kcnq2 participated on our site, such as Axon guidance, Cholinergic synapse, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with kcnq2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Axon guidance LRRC4; DUSP6; RHOA; FRS2A; NFATC3; CNTN6; KCNQ2; CXCR4; EFNA1B; PAK7
    Cholinergic synapse GNG5; CHRM5; PIK3R1; GNG12; BCL2; KCNJ6; KRAS; PIK3R2; CAMK2G; CHRNA7
    Developmental Biology SPTA1; CNTN1; WDR83; PLXNC1; COL9A1; DPYSL2B; NR5A1; KCNQ3; NR6A1; FRS3
    Interaction between L1 and Ankyrins SCN9A; KCNQ2; NADL1.1; KCNQ3; SCN2B; SCN4A; SCN8A; ANK2B; SCN2A; SCN3A
    L1CAM interactions RANBP9; DPYSL2B; SCN2B; SCN3A; ANK2B; KIF4; DLG3; DPYSL2; NRP2; KCNQ2
    Neuronal System KCNK7; KCNB2; ARL6IP5B; KCNJ1A.4; KCNH1B; PPFIA4; LIN7B; KCNK4; RAB3AA; NCALDA
    Potassium Channels KCNV1; KCNS2; KCNH5; KCNG3; DDX1; KCNQ1; KCNA1; ABCC9; KCNH1; KCNB2
    Voltage gated Potassium channels KCNH6A; KCNV2; KCNA7; KCNC1B; KCND1; KCNA6; KCNH2; KCNQ2; KCNS3A; KCNC1

    kcnq2 has several biochemical functions, for example, ankyrin binding, delayed rectifier potassium channel activity, potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kcnq2 itself. We selected most functions kcnq2 had, and list some proteins which have the same functions with kcnq2. You can find most of the proteins on our site.

    Function Related Protein
    ankyrin binding KCTD6; SLC4A1; SPTBN1; RHAG; SCN5A; SLC8A1; PTBP3; OBSCN; ATP1A1; RHBG
    delayed rectifier potassium channel activity KCNG2; KCNF1A; KCNA2; KCNF1; KCNA2B; KCNA6A; KCNQ4; KCNS3; KCNQ3; KCNV2
    potassium channel activity KCNQ4; KCNK10B; KCNK1A; KCNH5; KCNV2B; KCNK5A; KCNC3B; PKD2; KCNC4; KCNC3A
    protein N-terminus binding RND2; THAP7; TDRD7; HDAC1; MAU2; CSNK2A1; BIRC2; EIF3E; TAF11; ACOX1
    voltage-gated potassium channel activity KCNB2; KCNH8; KCNC3B; KCNK9; KCNQ5; KCNS3A; CNGA1; KCNQ3; KCNE3; KCNH6A

    kcnq2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kcnq2 here. Most of them are supplied by our site. Hope this information will be useful for your research of kcnq2.

    ARIH2

    Bocksteins, E; Van de Vijver, G; et al. K(v)3 channels contribute to the delayed rectifier current in small cultured mouse dorsal root ganglion neurons. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 303:C406-C415(2012).
    Pulkes, T; Dejthevaporn, C; et al. Paroxysmal neuromyotonia: A new sporadic channelopathy. NEUROMUSCULAR DISORDERS 22:479-482(2012).

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