LYN

  • Official Full Name

    v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  • Overview

    Lyn, one of the Src family members, is predominantly expressed in hematopoietic cells. Two tyrosine residues have been reported to play a crucial role in the regulation of protein tyrosine kinases of the Src family. Autophosphorylation of Tyr396 (equivale
  • Synonyms

    LYN;v-yes-1 Yamaguchi sarcoma viral related oncogene homolog;tyrosine-protein kinase Lyn;JTK8;lck/Yes-related novel protein tyrosine kinase;p53Lyn;p56Lyn;FLJ26625

Recombinant Proteins

  • Human
  • Zebrafish
  • Chicken
  • Rat
  • Mouse
  • E.coli
  • Insect Cells
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • Wheat Germ
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Flag
  • Myc&DDK
  • His&Fc&Avi
  • His&Myc
  • His&GST
Cat.# Product name Source (Host) Species Tag Protein Length Price
LYN-514H Recombinant Human LYN Protein, His-tagged E.coli Human His Val263~Pro491
LYN-252H Active Recombinant Human LYN Protein, GST-tagged Insect Cells Human GST 1-512 a.a.
LYN-1127H Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, GST-tagged Sf9 Cells Human GST
LYN-1254H Recombinant Human V-Yes-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog, His-tagged Insect Cells Human Non Full L.
LYN-1267Z Recombinant Zebrafish LYN Mammalian Cells Zebrafish His
LYN-1532C Recombinant Chicken LYN Mammalian Cells Chicken His
LYN-27984TH Recombinant Human LYN Human Non
LYN-28760TH Recombinant Human LYN E.coli Human Non 1-100 a.a.
LYN-3514R Recombinant Rat LYN Protein Mammalian Cells Rat His
LYN-61H Recombinant Human LYN protein, Flag-tagged, Biotinylated Insect Cells Human Flag 1-512 a.a.
LYN-643H Recombinant Human LYN protein, His-tagged E.coli Human His 1-100 a.a.
LYN-7218H Recombinant Human LYN, His-tagged E.coli Human His 1-512aa
LYN-9386M Recombinant Mouse LYN Protein Mammalian Cells Mouse His
LYN-656HCL Recombinant Human LYN cell lysate Insect Cells Human Non
LYN-0766H Recombinant Human LYN Protein (K233-P512), Tag Free Insect Cells Human Non K233-P512
LYN-0767H Recombinant Human LYN Protein (K233-P512), His tagged Insect Cells Human His K233-P512
LYN-12H Recombinant Human LYN Protein (Full Length), N-FLAG tagged Insect Cells Human Flag Full L. Full Length
LYN-1343H Recombinant Human LYN Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
LYN-2705H Recombinant Human LYN Protein (Met263-Asp491), His tagged E.coli Human His Met263-Asp491
LYN-3071HF Active Recombinant Full Length Human LYN Protein, GST-tagged Sf21 Cells Human GST Full L. 1-491(end)
LYN-3170R Recombinant Rat LYN Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
LYN-3170R-B Recombinant Rat LYN Protein Pre-coupled Magnetic Beads HEK293 Rat
Lyn-3194M Recombinant Mouse Lyn protein, His&Myc-tagged E.coli Mouse His&Myc 2-512aa
Lyn-3877M Recombinant Mouse Lyn Protein, Myc/DDK-tagged HEK293 Mouse Myc&DDK
LYN-4556H Recombinant Human LYN Protein, GST-tagged Wheat Germ Human GST
LYN-4557H Active Recombinant Human LYN Protein, GST/His-tagged Insect Cells Human His&GST
LYN-4696HF Active Recombinant Full Length Human LYN Protein, GST-tagged Sf21 Cells Human GST Full L. 1-512(end)
LYN-4990H Recombinant Human LYN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
LYN-5263M Recombinant Mouse LYN Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
LYN-5263M-B Recombinant Mouse LYN Protein Pre-coupled Magnetic Beads HEK293 Mouse
LYN-6237HF Recombinant Full Length Human LYN Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 512 amino acids
LYN-9787HF Active Recombinant Full Length Human LYN Protein, DDK-tagged, Biotinylated Sf21 Cells Human Flag Full L. 1-512(end)
LYNA-760H Active Recombinant Human LYNA Protein, His/GST-tagged Insect Cells Human His&GST Full L. 1-512 a.a.

    Involved Pathway

    LYN involved in several pathways and played different roles in them. We selected most pathways LYN participated on our site, such as Chemokine signaling pathway,NF-kappa B signaling pathway,Platelet activation, which may be useful for your reference. Also, other proteins which involved in the same pathway with LYN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Epithelial cell signaling in Helicobacter pylori infection IKBKB,ATP6V0A1,IKBKG,MAPK12,RAC1,ATP6V0C,MAP2K4,SRC,CDC42,ATP6V1A
    Fc epsilon RI signaling pathway GM-CSF,MAP2K6,MAPK12,RAC2,IL5,PIK3R1,PIK3CB,MAPK11,MAP2K3,SYK
    B Cell Receptor Signaling Pathway PILRB,DUSP4,PLEKHA2,RASGRP3,CD79A,CRKL,VAV3,PDK2,PIK3CG,LCP2A
    Long-term depression HRAS,PRKG2,PLCB1,ITPR1,BRAF,ITPR3,GNAI2,KRAS,MAPK1,GRIA2
    Chemokine signaling pathway SHC2,HRAS,VAV1,Adcy4,FOXO3,GNG10,CXCL5,PARD3,GNG4,JAK3
    Epstein-Barr virus infection IKBKG,ENTPD3,AKAP8L,STAT3,POLR3F,TBPL1,CD44,SKP2,POLR2H,HLA-DPA1
    Viral carcinogenesis HIST1H2BG,BAD,TRAF1,DLG1,HLA-A,HDAC10,HLA-C,CREB5,CDC20,MAPK1
    NF-kappa B signaling pathway BLNK,VCAM1,BTK,CCL13,ZAP70,TNFSF11,BCL2A1A,ICAM1,IL-8,CCL19
    Platelet activation PRKG1,PLCG2,PRKG2,PRKCI,TBXA2R,MYL12A,PLCB1,ARHGEF12,PTGS1,VWF

    Protein Function

    LYN has several biochemical functions, for example, ATP binding,SH3 domain binding,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LYN itself. We selected most functions LYN had, and list some proteins which have the same functions with LYN. You can find most of the proteins on our site.

    Function Related Protein
    ion channel binding SNTA1,RIMS1,AKAP9,RYR2,PACS1,RNF207,KCNH5,PPP1R9B,EPN1,KCNE4
    glycosphingolipid binding SELL,SELP,Cel,LAMB1,Il2,LAMA1,LAMC1
    platelet-derived growth factor receptor binding PTEN,Pdgfa&Pdgfb,PDGFAA,IL1R1,TYMP,PDGFAB,PDGFRA,ITGA5,PDGFRB,ITGB3
    SH3 domain binding CCDC6,ABI2,SH3BGRL,PLSCR3,ADAM10,NCF1,EPS15,ITM2B,EVL,SH3BP1
    protein binding ETS2,ALG2,RCN2,SUGP1,ARL6IP4,DCLRE1B,ADD1,HDGFRP2,PROCR,DCP1A
    receptor binding TNFSF15,FRK,CHRNA10,APLN,PRDX5,CD72,FGF24,TNFSF18,DAO1,CNPY3
    gamma-tubulin binding FEZ1,NDRG1,CEP57L1,BLOC1S2A,BLOC1S2,TUBGCP4,RACGAP1,TUBGCP3,BRCA2,RAD51D
    integrin binding ITGA3,MMP14,ADAM22,ITGB1BP2,NIPAL1,DST,ANXA7,WISP1B,CTGFA,ICAM2
    enzyme binding ATF7,GSTM1,APOA5,MLEC,CAD,CREB1,THRB,WWOX,PEBP1,GSTM4

    Interacting Protein

    LYN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LYN here. Most of them are supplied by our site. Hope this information will be useful for your research of LYN.

    EGFR;polg_hcvh;polg_hcvco;KHDRBS1;polg_hcvj4;PTK2;tip_shv2c

    Resources

    References

    • Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
    • Xiao, ZG; Sperl, B; et al. Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. ONCOTARGET 5:12877-12890(2014).

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