MAGI2

  • Official Full Name

    membrane associated guanylate kinase, WW and PDZ domain containing 2

  • Overview

    The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
  • Synonyms

    MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; ACVRIP1; AIP1; ARIP1; KIAA0705; MAGI 2; WW and PDZ domain-containing protein 2; Activin receptor interacting protein 1; Acvri1; Acvrinp1; AIP 1; Aip-1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAGI2-709H Recombinant Human MAGI2, GST-tagged E.coli GST
Human MAGI2-1347H Recombinant Human MAGI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAGI2-5578H Recombinant Human MAGI2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAGI2-1347H-B Recombinant Human MAGI2 Protein Pre-coupled Magnetic Beads HEK293
Human MAGI2-334H Recombinant Human MAGI2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAGI2-333HFL Recombinant Full Length Human MAGI2 Protein, C-Flag-tagged Mammalian cells Flag
Mouse MAGI2-9462M Recombinant Mouse MAGI2 Protein Mammalian Cell His
Mouse Magi2-3905M Recombinant Mouse Magi2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAGI2-5302M-B Recombinant Mouse MAGI2 Protein Pre-coupled Magnetic Beads HEK293
Mouse MAGI2-5302M Recombinant Mouse MAGI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAGI2-3542R Recombinant Rat MAGI2 Protein Mammalian Cell His
Rat MAGI2-3198R-B Recombinant Rat MAGI2 Protein Pre-coupled Magnetic Beads HEK293
Rat MAGI2-3198R Recombinant Rat MAGI2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish MAGI2-6569Z Recombinant Zebrafish MAGI2 Mammalian Cell His
Chicken MAGI2-4374C Recombinant Chicken MAGI2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAGI2 Related Articles
  • MAGI2 Related Gene Family

MAGI2 involved in several pathways and played different roles in them. We selected most pathways MAGI2 participated on our site, such as Rap signaling pathway, Tight junction, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAGI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Rap signaling pathwayGNAQ;FGF3;PRKCG;MET;VEGFA;KLK1B4;GRIN1;FIGF;RAP1A
Tight junctionCLDN10A;CLDN4;PARD3;CASKB;LLGL2;KRAS;PRKCZ;RHOAA;PRKCDA
TNF signaling pathwayFAS;TRAF5;BIRC2;CASP7;IKBKB;MAP3K7;NFKB1;IL15;CXCL3

MAGI2 has several biochemical functions, for example, SMAD binding, beta-1 adrenergic receptor binding, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAGI2 itself. We selected most functions MAGI2 had, and list some proteins which have the same functions with MAGI2. You can find most of the proteins on our site.

Function Related Protein
SMAD bindingCOL5A2;SKILB;SKIA;TGFBRAP1;COL3A1;SKOR1A;SNW1;STUB1;DAB2
beta-1 adrenergic receptor bindingMAGI2;DLG4
phosphatase bindingPPP1R32;CSRNP2;CTSC;WNK1;TPRN;SH3YL1;PPARA;ELFN1;PPP1R37
protein bindingKRTAP19-7;NR2F1;RAD51D;RUFY4;RFC4;GSK3A;POU1F1;CRYBA1;DIS3L2
receptor signaling complex scaffold activitySHANK1;NCK1;CARD10;ROPN1B;NCK2;G3BP2;GRIP2A;MAGI2;MAPK8IP3
signal transducer activityTRHRB;GRM6A;GPR25;TAAR12J;S1PR3A;CHRM5A;ECT2;OLFR1002;GNG7
type II activin receptor bindingINHBA;MAGI2

MAGI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAGI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAGI2.

ADRB1; RAPGEF2; TGFA; POLR2A; POLR2B; AMOTL1; q8clu2_yerpe; DSCAML1; PLXNB3

Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
McGovern, DPB; Taylor, KD; et al. MAGI2 Genetic Variation and Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES 15:75-83(2009).
TGF
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