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Official Full Name membrane associated guanylate kinase, WW and PDZ domain containing 2
Background The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.
Synonyms MAGI2; membrane associated guanylate kinase, WW and PDZ domain containing 2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2; ACVRIP1; AIP1; ARIP1; KIAA0705; MAGI 2; WW and PDZ domain-containing protein 2; Activin receptor interacting protein 1; Acvri1; Acvrinp1; AIP 1; Aip-1; Atrophin 1 interacting protein 1; Atrophin 1 interacting protein A; Atrophin-1-interacting protein 1; Atrophin-1-interacting protein A; MAGI-2; MAGI2_HUMAN; Membrane associated guanylate kinase 2; Membrane associated guanylate kinase inverted 2; Membrane associated guanylate kinase WW and PDZ domain containing 2; Membrane associated guanylate kinase WW and PDZ domain containing protein 2; Membrane-associated guanylate kinase; Membrane-associated guanylate kinase inverted 2; S SCAM; SSCAM
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAGI2-334H Recombinant Human MAGI2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human MAGI2-5578H Recombinant Human MAGI2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAGI2-709H Recombinant Human MAGI2, GST-tagged E.coli GST
    Mouse Magi2-3905M Recombinant Mouse Magi2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAGI2-9462M Recombinant Mouse MAGI2 Protein Mammalian Cell His
    Rat MAGI2-3542R Recombinant Rat MAGI2 Protein Mammalian Cell His
    Chicken MAGI2-4374C Recombinant Chicken MAGI2 Mammalian Cell His
    Zebrafish MAGI2-6569Z Recombinant Zebrafish MAGI2 Mammalian Cell His

    magi2 involved in several pathways and played different roles in them. We selected most pathways magi2 participated on our site, such as Rap signaling pathway, Tight junction, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with magi2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway IGF1; FGF13; CDC42; VAV2; RRAS; MAPK3; KRIT1; PGF; P2RY1; PRKD2
    Tight junction OCLNA; PPP2R1A; KRAS; JAM3B; EPB41L3B; CLDN15; MRAS; MYH1B; LLGL1; MYH11A
    TNF signaling pathway CXCL5; MAPK8; IL6; TRADD; MMP3; VCAM1; SELE; TRAF3; BIRC2; CFLAR

    magi2 has several biochemical functions, for example, SMAD binding, beta-1 adrenergic receptor binding, phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by magi2 itself. We selected most functions magi2 had, and list some proteins which have the same functions with magi2. You can find most of the proteins on our site.

    Function Related Protein
    beta-1 adrenergic receptor binding DLG4; MAGI2
    phosphatase binding MAPK3; SH3YL1; PPP1R21; CNST; PPP1R37; SH3GL1; TPRN; TSC2; MAST2; CSRNP2
    protein binding PEX11A; TLX2; LSM6; BCL2L16; TACR1; BCAR3; RXRB; APOBEC3F; EIF4E2; KLRC4-KLRK1
    receptor signaling complex scaffold activity MAGI2; SHANK1; GRIP1; AXIN1; CARD10; G3BP2; LDLRAP1; RGS14; LRRK2; ROPN1B
    signal transducer activity OLFR481; RGRB; TAS2R138; TAAR10A; VMN1R46; TAAR14I; CANT1; MRGPRA7; TRHRB; GNGT2B
    type II activin receptor binding INHBA; MAGI2

    magi2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with magi2 here. Most of them are supplied by our site. Hope this information will be useful for your research of magi2.


    Wolters, VM; Alizadeh, BZ; et al. Intestinal barrier gene variants may not explain the increased levels of antigliadin antibodies, suggesting other mechanisms than altered permeability. HUMAN IMMUNOLOGY 71:392-396(2010).
    McGovern, DPB; Taylor, KD; et al. MAGI2 Genetic Variation and Inflammatory Bowel Disease. INFLAMMATORY BOWEL DISEASES 15:75-83(2009).


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