Official Full Name
mitogen-activated protein kinase kinase kinase 11
BackgroundThe protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
SynonymsMAP3K11; mitogen-activated protein kinase kinase kinase 11; MLK3, PTK1; MEKK11; SPRK; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase; MLK3; PTK1; MLK-3;