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Official Full Name mitogen-activated protein kinase kinase kinase 11
Background The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
Synonyms MAP3K11; mitogen-activated protein kinase kinase kinase 11; MLK3, PTK1; MEKK11; SPRK; mixed lineage kinase 3; protein-tyrosine kinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3 domain-containing proline-rich kinase; MLK3; PTK1; MLK-3
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP3K11-1039H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-Tagged Sf9 Insect Cell GST
    Human MAP3K11-1257H Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-tagged Insect Cell GST
    Mouse MAP3K11-9507M Recombinant Mouse MAP3K11 Protein Mammalian Cell His
    Rat MAP3K11-3564R Recombinant Rat MAP3K11 Protein Mammalian Cell His
    Rhesus Macaque MAP3K11-2666R Recombinant Rhesus monkey MAP3K11 Protein, His-tagged Mammalian Cell His

    map3k11 involved in several pathways and played different roles in them. We selected most pathways map3k11 participated on our site, such as MAPK signaling pathway, Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with map3k11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAPK14B; STMN1; GNG12; CDC42; CACNA2D4; CACNB4; TGFB3; MAP2K7; NRAS; PLA2G4D
    Non-alcoholic fatty liver disease (NAFLD) PIK3CD; NDUFS8; NDUFA4L2; NDUFA12; UQCR11; NDUFA1; SDHC; NDUFB11; NDUFC2; IL6

    map3k11 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map3k11 itself. We selected most functions map3k11 had, and list some proteins which have the same functions with map3k11. You can find most of the proteins on our site.

    Function Related Protein
    JUN kinase kinase kinase activity MAP3K10; MAP3K9; MAP3K11; MAP3K1; ALPK2
    Rac GTPase binding PAK3; PAK1; ITPKA; RAB7A; ARHGEF2; SRGAP2B; CAV1; SRGAP3; NCF2; PKN1
    identical protein binding ENTPD2; PKD2; CLDN15; SRPX2; PTS; IMPA1; ITGA2B; MMP9; CLDND; CUBN
    mitogen-activated protein kinase kinase binding ACE; BRAF; TAOK2; TRIB1; IGBP1; ARRB1; PIN1; MAP3K11; MAPK8IP3; TRIB3
    mitogen-activated protein kinase kinase kinase binding CDC42; TRAF2; MARVELD3; MAPK1; MAP2K1; DUSP19; MAPK9; TCF3; PPEF2; STK38
    protein binding KCNB1; WNT3A; B2M; C19orf47; VENTX; UQCC2; SAE1; BNIP2; CAMK1; JRK
    protein homodimerization activity SRF; KIAA1804; ALDH1A3; TBX18; MGST1; MYH9; MAPK4; NFS1; ABCD2; CER1
    protein kinase activity JAK2A; PTK2BB; EPHA2A; EPHB4B; MAP4K3; RPS6KB2; SIK2A; BMPR1AB; PDK2; DYRK3
    protein serine/threonine kinase activity PKN1; VRK3; STK3; PRKCA; KALRN; CDK12; DCLK1; CAMK2D2; SRPK3; LMTK2
    protein tyrosine kinase activity EGFRA; ROS1; WEE2; PTK2AB; EPHB2; PDGFRB; INSRA; EPHA4A; ABL2; TTN

    map3k11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map3k11 here. Most of them are supplied by our site. Hope this information will be useful for your research of map3k11.

    NF2; q99ib8-pro_0000045602; CDC42; Map4k1; PIK3R1; saicar; PKM

    Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
    Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).

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