MAP3K11
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Official Full Name
mitogen-activated protein kinase kinase kinase 11 -
Overview
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. -
Synonyms
MAP3K11;mitogen-activated protein kinase kinase kinase 11;MLK3, PTK1;MEKK11;SPRK;mixed lineage kinase 3;protein-tyrosine kinase PTK1;SH3 domain-containing proline-rich kinase;src-homology 3 domain-containing proline-rich kinase;MLK3;PTK1;MLK-3
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
Involved Pathway
MAP3K11 involved in several pathways and played different roles in them. We selected most pathways MAP3K11 participated on our site, such as MAPK signaling pathway,Non-alcoholic fatty liver disease (NAFLD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | CACNG4,IL1B,PPM1NB,PDGFRB,GADD45G,TGFB2,RAF1B,STMN1,TNFRSF1A,CDC42L2 |
| Non-alcoholic fatty liver disease (NAFLD) | PRKAB1,NDUFA4L2,PKLR,NDUFB2,NDUFA5,TGFB1,COX4I2,SOCS3,Il6ra,PIK3R2 |
Protein Function
MAP3K11 has several biochemical functions, for example, ATP binding,JUN kinase kinase kinase activity,Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K11 itself. We selected most functions MAP3K11 had, and list some proteins which have the same functions with MAP3K11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACSL1,SPS2,BBS10,EHD2,NTRK1,TTK,ERBB4A,MKNK2A,BLK,DHX32A |
| protein kinase activity | TRIOA,ACVR2AA,HIPK3B,SGK2A,NRBP1,PIK3CG,CAMK2G1,MAP2K5,BMPR1AB,NEK10 |
| mitogen-activated protein kinase kinase kinase binding | MARVELD3,CDC42,CDC37,STK38,MAP4K2,TCF3,MAPK9,PPEF2,MAP2K1,DUSP19 |
| protein tyrosine kinase activity | PTK2,EPHB4B,TESK1,DSTYK,CSK,FGFR4,ZAP70,IGF1RB,EPHA2A,EPHA4B |
| JUN kinase kinase kinase activity | MAP3K10,MAP3K1,ALPK2,MAP3K9 |
| Rac GTPase binding | PAK4,PKN1,NOXA1,PAK1,ARHGAP4A,PAK6,NCF2,DVL1,EPS8,ITPKA |
| protein homodimerization activity | UGT1A2,HPRT1,UPK1A,GREM2,NTSR1,VPS25,HMGCR,IL12B,TRIM9,HNF4A |
| protein binding | WASH1,CD33,VLDLR,UBE2N,SOCS6,CNOT2,PIP4K2B,EXOSC1,CHMP4B,FAM113B |
| protein serine/threonine kinase activity | CIT,PRKCQ,SBK3,MAPK8,STK40,TGFBR1,SLC14A2,TNK2,KALRN,CSNK1G2 |
Interacting Protein
MAP3K11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K11.
NF2;q99ib8-pro_0000045602;CDC42;Map4k1;PIK3R1;saicar;PKM
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References
- Kimura, M; Moteki, H; et al. Involvement of endogenous transforming growth factor-alpha in signal transduction pathway for interleukin-1 beta-induced hepatocyte proliferation. EUROPEAN JOURNAL OF PHARMACOLOGY 745:223-233(2014).
- Liu, SQ; Jia, H; et al. Recombinant TB10.4 of Mycobacterium bovis induces cytokine production in RAW264.7 macrophages through activation of the MAPK and NF-kappa B pathways via TLR2. MOLECULAR IMMUNOLOGY 62:227-234(2014).
