Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-tagged
Cat.No. : | MAP3K11-1257H |
Product Overview : | Recombinanthuman full length MAP3K11, GST-tagged, is expressed in Insect cells. |
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Cat. No. : | MAP3K11-1257H | ||
Description : | MAP3K11is a serine/threonine kinase that activates both the p38 MAP kinase and c-Junkinase pathways. The protein encoded by this gene is a member of theserine/threonine kinase family. This kinase contains a SH3 domain and aleucine zipper-basic motif. This kinase preferentially activates MAPK8/JNKkinase, and functions as a positive regulator of JNK signaling pathway. Thiskinase can directly phosphorylate, and activates IkappaB kinase alpha andbeta, and is found to be involved in the transcription activity of NF-kappaBmediated by Rho family GTPases and CDC42. | ||
Source : | Insect cells | ||
Species : | Human | ||
Form : | Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol. | ||
Molecular Weight : | 120.1 kDa | ||
Specific Activity : | 43 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml. | ||
Concentration : | 0.15mg/ml | ||
Storage : | Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles. | ||
OfficialSymbol : | MAP3K11 | ||
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Gene Name : | MAP3K11 mitogen-activatedprotein kinase kinase kinase 11 [ Homo sapiens ] |
Synonyms : | MAP3K11; mitogen-activatedprotein kinase kinase kinase 11; MLK3; PTK1; SPRK; MLK-3; MEKK11;MGC17114; OTTHUMP00000233249; OTTHUMP00000233268; mixed lineage kinase 3; protein-tyrosinekinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3domain-containing proline-rich kinase; EC 2.7.11.25 |
Gene ID : | 4296 |
mRNA Refseq : | NM_002419 |
Protein Refseq : | NP_002410 |
MIM : | 600050 |
UniProt ID : | Q16584 |
Chromosome Location : | 11q13.1-q13.3 |
Pathway : | Insulin Signaling; MARKsignaling pathway; CDC42 signaling events; IFN-gamma pathway; RAC1 signalingpathway; Reelin signaling pathway; superpathway of gluconate degradation |
Products Types
◆ Recombinant Protein | ||
MAP3K11-2486R | Recombinant Rhesus Macaque MAP3K11 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP3K11-3220R | Recombinant Rat MAP3K11 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP3K11-5328M | Recombinant Mouse MAP3K11 Protein, His (Fc)-Avi-tagged | +Inquiry |
MAP3K11-3564R | Recombinant Rat MAP3K11 Protein | +Inquiry |
MAP3K11-2666R | Recombinant Rhesus monkey MAP3K11 Protein, His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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