Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 11, GST-tagged

• Cat.No.: MAP3K11-1257H
• Product Overview: Recombinanthuman full length MAP3K11, GST-tagged, is expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: GST
• Protein Length: 1-847 aa
• Description: MAP3K11is a serine/threonine kinase that activates both the p38 MAP kinase and c-Junkinase pathways. The protein encoded by this gene is a member of theserine/threonine kinase family. This kinase contains a SH3 domain and aleucine zipper-basic motif. This kinase preferentially activates MAPK8/JNKkinase, and functions as a positive regulator of JNK signaling pathway. Thiskinase can directly phosphorylate, and activates IkappaB kinase alpha andbeta, and is found to be involved in the transcription activity of NF-kappaBmediated by Rho family GTPases and CDC42.
• Form: Liquid in50 mM Tris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mMDTT + 50% glycerol.
• Molecular Weight: 120.1 kDa
• Specific Activity: 43 nmoleof phosphate transferred to myelin basic protein (MBP) per minute per mg of totalprotein at 30°C. Activity determined at a final protein concentration of 8.33μg/ml.
• Concentration: 0.15mg/ml
• Storage: Stablefor 6 months in working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: MAP3K11
• Function: ATP binding; JUNkinase kinase kinase activity; Eac GTPase binding; identical protein binding;mitogen-activated protein kinase kinase kinase binding; mitogen-activatedprotein kinase kinase binding; protein kinase activity; nucleotide binding; proteinserine/tyreonine kinase activity; protein homodimerization activity; proteintyrosine kinase activity
• Full Length: Full L.

Gene Information

• Gene Name: MAP3K11 mitogen-activatedprotein kinase kinase kinase 11 [ Homo sapiens ]
• Synonyms: MAP3K11; mitogen-activatedprotein kinase kinase kinase 11; MLK3; PTK1; SPRK; MLK-3; MEKK11;MGC17114; OTTHUMP00000233249; OTTHUMP00000233268; mixed lineage kinase 3; protein-tyrosinekinase PTK1; SH3 domain-containing proline-rich kinase; src-homology 3domain-containing proline-rich kinase; EC 2.7.11.25
• Gene ID: 4296
• mRNA Refseq: NM_002419
• Protein Refseq: NP_002410
• MIM: 600050
• UniProt ID: Q16584
• Chromosome Location: 11q13.1-q13.3
• Pathway: Insulin Signaling; MARKsignaling pathway; CDC42 signaling events; IFN-gamma pathway; RAC1 signalingpathway; Reelin signaling pathway; superpathway of gluconate degradation