MAP3K9

Official Full Name

mitogen-activated protein kinase kinase kinase 9
Overview

Mixed-lineage kinases (MLKs) belong to the mitogen activated kinase kinase kinase (MAPKKK) family of dual-specificity protein kinases. While not particularly well conserved at the sequence level, MLK1, 2 and 3 share a conserved domain structure consisting
Synonyms

MAP3K9; mitogen-activated protein kinase kinase kinase 9; MLK1; MEKK9; PRKE1; mixed lineage kinase 1 (tyr and ser/thr specificity);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Mouse

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Sf21
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MAP3K9-152H	Active Recombinant Human MAP3K9(134-414) Protein, N-His-tagged	Sf21	His	134-414 aa	Inquiry
Human	MAP3K9-1040H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-Tagged	Sf9 Insect Cell	GST	1-433	Inquiry
Human	MAP3K9-1262H	Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-tagged	Insect Cell	GST	1-500	Inquiry
Human	MAP3K9-3052H	Recombinant Human MAP3K9 protein, His-tagged	E.coli	His	575-821 aa	$319 / 25μg
Mouse	MAP3K9-9519M	Recombinant Mouse MAP3K9 Protein	Mammalian Cell	His		Inquiry
Mouse	MAP3K9-5336M-B	Recombinant Mouse MAP3K9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MAP3K9-5336M	Recombinant Mouse MAP3K9 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MAP3K9 involved in several pathways and played different roles in them. We selected most pathways MAP3K9 participated on our site, such as Insulin Signaling, p38 MAPK Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP3K9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Insulin Signaling	STXBP3A;RHOJ;CAP1;KIF5B;MAPK6;SNAP25A;MAP3K10;STXBP3;MAPK4
p38 MAPK Signaling Pathway	MAP3K10;MAP3K9;GADD45G

MAP3K9 has several biochemical functions, for example, ATP binding, JUN kinase kinase kinase activity, MAP kinase kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP3K9 itself. We selected most functions MAP3K9 had, and list some proteins which have the same functions with MAP3K9. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	YME1L1;CAMK1;PHKG2;DDX59;BMPR1AA;AURKA;MLH3;IRAK1;CBWD1
JUN kinase kinase kinase activity	MAP3K11;MAP3K10;MAP3K1;MAP3K9;ALPK2
MAP kinase kinase activity	MAP2K2;MAPK10;PAK3;MAP2K7;SBK3;ALPK2;MAPK14;LRRK2;MAP3K9
protein binding	SUV420H2;GH1;S100P;RWDD2B;TREX1;NLRC5;RPS27L;SHROOM2;WDR48
protein homodimerization activity	PDGFB;HM13;NTRK1;UGT1A3;HPGDS;GRPEL2;TYMS;TFAP2A;PAFAH1B1
protein serine/threonine kinase activity	PBK;BCR;PHKG1A;PHKG1B;PAK4;BMPR1A;SMG1;STK10;PRKACBB
protein tyrosine kinase activity	LTK;KIT;EPHA4A;TNK2;DSTYK;KITB;BAZ1B;PTK2B;FGFR4

MAP3K9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP3K9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP3K9.

HSP90AB1; abl-tide

Research Area

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).

Jeon, JH; Kim, YH; et al. Bacillus anthracis genomic DNA enhances lethal toxin-induced cytotoxicity through TNF-alpha production. BMC MICROBIOLOGY 14:-(2014).