Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-Tagged
Cat.No. : | MAP3K9-1040H |
Product Overview : | Recombinant human MAP3K9 (1-433) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
- Specification
- Gene Information
- Related Products
Cat. No. : | MAP3K9-1040H |
Description : | MAP3K9 or Mixed-Lineage Kinase 1 is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH(2)-terminal kinase (JNK) pathway. The catalytic domain of MAP3K9 has amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition, MAP3K9 contain 2 leu/ile-zipper motifs and a basic sequence near its C-termini. MAP3K9 is threonine (and possibly serine) phosphorylated at multiple sites in the activation loop, with phosphorylation of Thr312 required for full activation. |
Applications : | Kinase Assay, Western Blot |
Molecular Weight : | 77 kDa |
Expression System : | Sf9 insect cells using baculovirus. |
Species : | Human |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 116 nmol/min/mg |
Purity : | > 85 % |
Concentration : | 0.1 ug/ul |
Sequences : | 1-433 |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Insulin Signaling; p38 MAPK Signaling Pathway |
Gene Name : | MAP3K9 mitogen-activated protein kinase kinase kinase 9 [ Homo sapiens ] |
Official Symbol : | MAP3K9 |
Synonyms : | MAP3K9; MLK1; MEKK9; PRKE1; mitogen-activated protein kinase kinase kinase 9; EC 2.7.11.25; mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 1; EC 2.7.11 |
Gene ID : | 4293 |
mRNA Refseq : | NM_033141 |
Protein Refseq : | NP_149132 |
MIM : | 600136 |
UniProt ID : | P80192 |
Chromosome Location : | 14q24.3-q31 |
Function : | ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; nucleotide binding; protein homo- dimerization activity; protein serine/threonine kinase activity; protein tyrosine kinase activity |
Products Types
◆ Recombinant Protein | ||
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MAP3K9-1262H | Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-tagged | +Inquiry |
MAP3K9-152H | Active Recombinant Human MAP3K9(134-414) Protein, N-His-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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