Recombinant Human Mitogen-Activated Protein Kinase Kinase Kinase 9, GST-Tagged
Cat.No. : | MAP3K9-1040H |
Product Overview : | Recombinant human MAP3K9 (1-433) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
ProteinLength : | 1-433 a.a. |
Description : | MAP3K9 or Mixed-Lineage Kinase 1 is a mitogen-activated protein kinase kinase kinase capable of activating the c-Jun NH(2)-terminal kinase (JNK) pathway. The catalytic domain of MAP3K9 has amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition, MAP3K9 contain 2 leu/ile-zipper motifs and a basic sequence near its C-termini. MAP3K9 is threonine (and possibly serine) phosphorylated at multiple sites in the activation loop, with phosphorylation of Thr312 required for full activation. |
Applications : | Kinase Assay, Western Blot |
Molecular Weight : | 77 kDa |
Expression System : | Sf9 insect cells using baculovirus. |
Form : | Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10mM glutathione, 0.25 mM DTT, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol. |
Specific Activity : | 116 nmol/min/mg |
Purity : | > 85 % |
Concentration : | 0.1 ug/ul |
Sequences : | 1-433 |
Storage : | Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Pathways : | Insulin Signaling; p38 MAPK Signaling Pathway |
Gene Name | MAP3K9 mitogen-activated protein kinase kinase kinase 9 [ Homo sapiens ] |
Official Symbol | MAP3K9 |
Synonyms | MAP3K9; MLK1; MEKK9; PRKE1; mitogen-activated protein kinase kinase kinase 9; EC 2.7.11.25; mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 1; EC 2.7.11 |
Gene ID | 4293 |
mRNA Refseq | NM_033141 |
Protein Refseq | NP_149132 |
MIM | 600136 |
UniProt ID | P80192 |
Chromosome Location | 14q24.3-q31 |
Function | ATP binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; nucleotide binding; protein homo- dimerization activity; protein serine/threonine kinase activity; protein tyrosine kinase activity |
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Not For Human Consumption!
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