MRPL23
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Official Full Name
mitochondrial ribosomal protein L23 -
Overview
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. The gene is biallelically expressed, despite its location within a region of imprinted genes on chromosome 11. -
Synonyms
MRPL23;mitochondrial ribosomal protein L23;RPL23L;39S ribosomal protein L23, mitochondrial;L23MRP;L23 mitochondrial-related protein;L23mt;MRP-L23;Ribosomal protein L23-like;ribosomal protein related to L23 (mitochondrial);RPL23
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
- GST
Involved Pathway
MRPL23 involved in several pathways and played different roles in them. We selected most pathways MRPL23 participated on our site, such as Ribosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with MRPL23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ribosome | RPL35A,MRPL19,RPS27A,RPL41,RPL4,RPS27L,RPLP0,MRPL32,RPL31,RPS17L |
Protein Function
MRPL23 has several biochemical functions, for example, RNA binding,nucleotide binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MRPL23 itself. We selected most functions MRPL23 had, and list some proteins which have the same functions with MRPL23. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| structural constituent of ribosome | MRPL12,RPS11,RPS26,RPS10,MRPS22,RPL35A,RPS27.1,RPS24,RPL23,RPS14 |
| nucleotide binding | DNM1A,ABCB6,PABPN1,SNRKA,SMYHC2,PABPC1,IGF2BP2,ABCB3L1,RTCB,ARL5C |
| protein binding | OCIAD1,ARL16,POLR3C,ISYNA1,Apba1,PEX13,AARSD1,UTP3,JAM3B,NR2C2 |
| RNA binding | RNASEN,ZNF385C,NOVA1,CRNKL1,CWC22,RPL22,PABPN1L,MIF4GDB,BARD1,CELF1 |
Interacting Protein
MRPL23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MRPL23 here. Most of them are supplied by our site. Hope this information will be useful for your research of MRPL23.
PNMA1;40038273;ATG12;C20orf24;USP44;NDUFAB1;ASB10;2_aha_camp;JAK3;YBX1;Ccser2;MRPL50;MRPL9;Cd2ap
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References
- Kaur, J; Stuart, RA; et al. Truncation of the Mrp20 protein reveals new ribosome-assembly subcomplex in mitochondria. EMBO REPORTS 12:950-955(2011).
- Haque, ME; Elmore, KB; et al. Properties of the C-terminal Tail of Human Mitochondrial Inner Membrane Protein Oxa1L and Its Interactions with Mammalian Mitochondrial Ribosomes. JOURNAL OF BIOLOGICAL CHEMISTRY 285:28353-28362(2010).
