NPFFR2
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Official Full Name
neuropeptide FF receptor 2 -
Overview
This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. -
Synonyms
NPFFR2;neuropeptide FF receptor 2;G protein coupled receptor 74 , GPR74;neuropeptide FF 2;NPFF2;NPGPR;G protein coupled receptor 74;G protein coupled receptor HLWAR 77;G protein coupled receptor HLWAR77;G-protein coupled receptor 74;G-protein coupled receptor HLWAR77;GPR 74;GPR74;HLWAR 77;HLWAR77;Neuropeptide G protein coupled receptor;Neuropeptide G-protein coupled receptor;NPFF 2;NPFF R2;NPFF2_HUMAN;NPFFR 2;G protein-coupled receptor 74
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi
- Fc
Involved Pathway
NPFFR2 involved in several pathways and played different roles in them. We selected most pathways NPFFR2 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPFFR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Class A/1 (Rhodopsin-like receptors) | RLN2,HRH3,UTS2,CHRM5,ADRA1D,TAC1,GPR17,GPR120,PROK1,UTS2D |
| Gastrin-CREB signalling pathway via PKC and MAPK | GPRC6A,GPR65,ABHD12,LPAR1,NMU,NMBA,ANXA1B,TAC3,NMS,RGS18 |
| GPCR ligand binding | SST1.1,GRP,CCBP2,UTS2D,TAS2R16,CNR1,NMBA,EDNRA,INSL5,ADM2 |
| GPCR downstream signaling | NPSR1,GPR17,PRKCHB,GPR4,CALCA,PMCH,OR56A1,ARHGEF18A,KALRNB,ARHGEF9 |
| Orexin and neuropeptides FF and QRFP bind to their respective receptors | HCRT,NPFF,QRFP,QRFPR |
| Neuroactive ligand-receptor interaction | CHRNB3A,TACR1B,PTGER4A,P2RX3B,PTH1RA,NPY2R,NMBR,TAAR14F,PTGER1C,HRH4 |
| G alpha (q) signalling events | NMU,KALRNB,APPA,FPR-RS4,OPN4.1,DGKB,FPR-RS3,PROK2,LTB4R,HCRT |
| GPCRs, Class A Rhodopsin-like | HRH3,DRD4,OR3A4P,OPN4,GPR77,APLNR,ADORA1,PTGDR2,SSTR4,GPR17 |
Protein Function
NPFFR2 has several biochemical functions, for example, G-protein coupled receptor activity,neuropeptide receptor activity,opioid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPFFR2 itself. We selected most functions NPFFR2 had, and list some proteins which have the same functions with NPFFR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| opioid receptor binding | NPFFR2.1 |
| G-protein coupled receptor activity | PTH1RA,GPRC5D,GHRHR2,GPR171,TAAR12I,MTNR1C,TAS1R2.2,OLFCS1,OXGR1A.1,OR4C13 |
| neuropeptide receptor activity | NPFFR1,KISS1RA,SORCS3,NPFFR2.1,SORCS1,GPR139,NPBWR2,HCRTR1,KISS1R,NMUR1 |
| peptide binding | ERCC3,HCRTR1,ANPEPB,Npepo,TRHDE,ERAP1,RPS6KB1,Ctsl,NUP98,LNPEP |
Interacting Protein
NPFFR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPFFR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPFFR2.
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