• Official Full Name

    purinergic receptor P2X, ligand-gated ion channel, 2

  • Background

    The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
  • Synonyms

    P2RX2; purinergic receptor P2X, ligand-gated ion channel, 2; P2X2; DFNA41; P2X purinoceptor 2; ATP receptor; P2X Receptor, subunit 2;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • His (Fc)
    • Avi
    • Myc
    • DDK
    • Myc|DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human P2RX2-143H Recombinant Human P2RX2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human P2RX2-492H Recombinant Human P2RX2 Mammalian Cell His
    Human P2RX2-142H Recombinant Human P2RX2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human P2RX2-144H Recombinant Human P2RX2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human P2RX2-5263H Recombinant Human P2RX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human P2RX2-3501HCL Recombinant Human P2RX2 293 Cell Lysate HEK293 N/A
    Human P2RX2-3775H-B Recombinant Human P2RX2 Protein Pre-coupled Magnetic Beads HEK293
    Human P2RX2-3775H Recombinant Human P2RX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse P2rx2-4635M Recombinant Mouse P2rx2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat P2RX2-3890R-B Recombinant Rat P2RX2 Protein Pre-coupled Magnetic Beads HEK293
    Rat P2RX2-4228R Recombinant Rat P2RX2 Protein Mammalian Cell His
    Rat P2RX2-3890R Recombinant Rat P2RX2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish P2RX2-9887Z Recombinant Zebrafish P2RX2 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • P2RX2 Related Research Area

    P2RX2 involved in several pathways and played different roles in them. We selected most pathways P2RX2 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Calcium signaling pathwayMYLK2;GRM1;CACNA1B;CALM2;SLC25A6;CACNA1H;TACR1;P2RX8;CHRM5
    Neuroactive ligand-receptor interactionTAAR14F;GNRHR2;MC3R;GLRBB;GABRB3;NPFFR1L2;DRD4B;TAAR12J;TAAR14I

    P2RX2 has several biochemical functions, for example, ATP binding, cadmium ion binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX2 itself. We selected most functions P2RX2 had, and list some proteins which have the same functions with P2RX2. You can find most of the proteins on our site.

    Function Related Protein
    cadmium ion bindingSLC11A2;NOS3;NOS1;MT3;P2RX2
    cobalt ion bindingPML;P2RX2;SLC11A2;BIRC5;NUDT16
    copper ion bindingSLC11A2;DCT;LOXL3A;S100U;TP53;SCO2;MOXD2;COX17;ATP7A
    drug bindingACE;Alb;CYP2C9;MTOR;DRD3;MT3;GLRB;PDE4D;DHFR
    extracellular ATP-gated cation channel activityP2RX4;P2RX5;P2RX7;NNR;P2RX1;P2RX3;P2RX2;P2RX6;P2RX8
    identical protein bindingCHEK2;BAX;NDC80;SHANK1;TP63;SOX10;APPL1;CIDEB;PDGFB
    ligand-gated ion channel activityCHRNB1;ZACN;CHRNB4;TRPA1B;CHRNB2;TRPA1A;GABRB1;CHRNA4;Chrng
    mercury ion bindingPARK7;P2RX2
    nickel cation bindingSLC11A2;P2RX2;CAR3;CA3
    phosphatidylinositol bindingARHGAP32;PIK3C2G;SNX1;SNX10B;SH3PXD2A;SNX32;NISCH;ITPR2;SNX27A
    purinergic nucleotide receptor activityP2RX3;P2RX4;P2RX5;P2RX1;P2RX3A;P2RX4B;P2RX3B;P2RX7;P2RX4A
    zinc ion bindingTRIM35-27;ADAMTS3;PDZRN3B;DHH;DDX41;MLL5;ZSWIM4;FHL2A;TRIM62

    P2RX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX2.

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