P2RX2
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Official Full Name
purinergic receptor P2X, ligand-gated ion channel, 2
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Background
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013] -
Synonyms
P2RX2; purinergic receptor P2X, ligand-gated ion channel, 2; P2X2; DFNA41; P2X purinoceptor 2; ATP receptor; P2X Receptor, subunit 2;
- Involved Pathway
- Protein Function
- Interacting Protein
- P2RX2 Related Research Area
P2RX2 involved in several pathways and played different roles in them. We selected most pathways P2RX2 participated on our site, such as Calcium signaling pathway, Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with P2RX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcium signaling pathway | MYLK2;GRM1;CACNA1B;CALM2;SLC25A6;CACNA1H;TACR1;P2RX8;CHRM5 |
| Neuroactive ligand-receptor interaction | TAAR14F;GNRHR2;MC3R;GLRBB;GABRB3;NPFFR1L2;DRD4B;TAAR12J;TAAR14I |
P2RX2 has several biochemical functions, for example, ATP binding, cadmium ion binding, cobalt ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by P2RX2 itself. We selected most functions P2RX2 had, and list some proteins which have the same functions with P2RX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MLKL;WEE1;MTHFD1;AKT3;KIFC3;FLT1;BAT1;NADKD1;UBE2M |
| cadmium ion binding | SLC11A2;NOS3;NOS1;MT3;P2RX2 |
| cobalt ion binding | PML;P2RX2;SLC11A2;BIRC5;NUDT16 |
| copper ion binding | SLC11A2;DCT;LOXL3A;S100U;TP53;SCO2;MOXD2;COX17;ATP7A |
| drug binding | ACE;Alb;CYP2C9;MTOR;DRD3;MT3;GLRB;PDE4D;DHFR |
| extracellular ATP-gated cation channel activity | P2RX4;P2RX5;P2RX7;NNR;P2RX1;P2RX3;P2RX2;P2RX6;P2RX8 |
| identical protein binding | CHEK2;BAX;NDC80;SHANK1;TP63;SOX10;APPL1;CIDEB;PDGFB |
| ligand-gated ion channel activity | CHRNB1;ZACN;CHRNB4;TRPA1B;CHRNB2;TRPA1A;GABRB1;CHRNA4;Chrng |
| mercury ion binding | PARK7;P2RX2 |
| nickel cation binding | SLC11A2;P2RX2;CAR3;CA3 |
| phosphatidylinositol binding | ARHGAP32;PIK3C2G;SNX1;SNX10B;SH3PXD2A;SNX32;NISCH;ITPR2;SNX27A |
| purinergic nucleotide receptor activity | P2RX3;P2RX4;P2RX5;P2RX1;P2RX3A;P2RX4B;P2RX3B;P2RX7;P2RX4A |
| zinc ion binding | TRIM35-27;ADAMTS3;PDZRN3B;DHH;DDX41;MLL5;ZSWIM4;FHL2A;TRIM62 |
P2RX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with P2RX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of P2RX2.
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