pag1 Protein, phosphoprotein associated with glycosphingolipid microdomains 1


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Official Full Name phosphoprotein associated with glycosphingolipid microdomains 1
Background Cyclic AMP-regulated gene expression frequently involves a DNA element designated the cAMP-regulated enhancer (CRE). Many transcription factors, including the protein CREB, which is activated as a result of phosphorylation by protein kinase A, bind to this element. It has been shown that protein kinase A-mediated CREB phosphorylation results in its binding to a 265 kDa nuclear protein designated CBP (for CREB-binding protein). These findings suggest that CBP has many of the properties expected of a CREB co-activator. Another high molecular weight transcriptional adapter protein, designated p300, is characterized by three cysteine- and histidine-rich regions, of which the most carboxy terminal region specifically binds the adenovirus E1A protein. p300 molecules lacking an intact E1A binding site bypass E1A repression even in the presence of high concentrations of E1A. Sequence analysis of CBP and p300 has revealed substantial homology, arguing that these proteins are members of a conserved family of co-activators.
Synonyms PAG1; phosphoprotein associated with glycosphingolipid microdomains 1; phosphoprotein associated with glycosphingolipid-enriched microdomains 1; CBP; Csk binding protein; PAG; transmembrane adaptor protein PAG; Csk-binding protein; transmembrane phosphoprotein Cbp; transmembrane adapter protein PAG; FLJ37858; MGC138364
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PAG1-30060TH Recombinant Human PAG1, His-tagged E.coli His
    Human PAG1-3465HCL Recombinant Human PAG1 293 Cell Lysate HEK293 N/A
    Mouse Pag1-521M Recombinant Mouse Pag1 Protein, His-tagged E.coli His
    Rat Pag1-522R Recombinant Rat Pag1 Protein, His-tagged E.coli His

    pag1 involved in several pathways and played different roles in them. We selected most pathways pag1 participated on our site, such as Adaptive Immune System, BCR signaling pathway, CXCR4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with pag1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System ITGB1B.1; PIK3AP1; LCP2A; LILRB5; MICA; UBR2; WWP1; AGO2; UBE2J2; AMICA1
    BCR signaling pathway POU2F2; MALT1; DOK1; CSNK2A1; MAP4K1; PAG1; IBTK; NETO2; CSK
    CXCR4-mediated signaling events ADRBK1; DNM1; CFL1; GNB2L1; JAK2; MAPKAP1; CSK; PAG1; ARR3; CRK
    GAB1 signalosome PAG1
    Immune System KLHL20; SRMS; CFD; IFI35; DEFB125; IFI30; RNF25; RNF123; LILRA2; NPEPPS
    Phosphorylation of CD3 and TCR zeta chains PAG1
    Signal Transduction HEBP1; CCL35.2; GPR120; FGFBP1; FAM123B; GPR68; CHN1; GNA13B; RGS20; FGFBP2
    Signaling by EGFR LRIG1; ADAM12; PAG1; PTPRK; SPRY1

    pag1 has several biochemical functions, for example, SH2 domain binding, SH3/SH2 adaptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pag1 itself. We selected most functions pag1 had, and list some proteins which have the same functions with pag1. You can find most of the proteins on our site.

    Function Related Protein
    SH2 domain binding SYP; NLK; CTR9; DLC1; CRK; LAX1; JAK2; SKAP1; TRPV4; MS4A2
    SH3/SH2 adaptor activity TOB1; SH3BGR; IRS4; EPS8; STAP1; PTPN11; ARHGAP4; SH2D1A; GRAP; NCK1
    protein binding H2-KE2; TMPRSS7; RPA2; KIAA1967; KHDC1A; STOML2; RPL9; ETV6; RAP1GDS1; NUDT4

    pag1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pag1 here. Most of them are supplied by our site. Hope this information will be useful for your research of pag1.


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