PDE6H involved in several pathways and played different roles in them. We selected most pathways PDE6H participated on our site, such as Purine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6H were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Purine metabolism |
POLR3A; PPAT; POLR2D; POLD1; PDE5AB; PDE3A; PDE4B; PDE4C; IMPDH2; AK3 |
PDE6H has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, cGMP binding, enzyme inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6H itself. We selected most functions PDE6H had, and list some proteins which have the same functions with PDE6H. You can find most of the proteins on our site.
| Function |
Related Protein |
| 3,5-cyclic-GMP phosphodiesterase activity |
PDE6B; PDE6A; PDE6G; PDE10A; PDE6C; PDE6H; PDE9A; PDE5A; PDE11A |
| cGMP binding |
PRKG1; PDE10A; CNGA5; PDE5A; CNGA4; PDE6C; PDE6H; PDE11A; CNGA1; PRKG2 |
| enzyme inhibitor activity |
ANGPTL3; GCHFR; UGT1A7; PPP1R12A; ATPIF1B; ATPIF1A; PDE6G; PRPSAP1; UGT1A9; NOTCH1 |
| protein binding |
MED24; YWHAH; BRD8; PRSS8; COMP; COMMD10; SGTB; CWC22; GNA13; UBA52 |
PDE6H has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6H here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6H.
COTL1; AGTR1
Aluru, N; Jenny, MJ; et al. Knockdown of a Zebrafish Aryl Hydrocarbon Receptor Repressor (AHRRa) Affects Expression of Genes Related to Photoreceptor Development and Hematopoiesis. TOXICOLOGICAL SCIENCES 139:381-395(2014).
Viringipurampeer, IA; Shan, X; et al. Rip3 knockdown rescues photoreceptor cell death in blind pde6c zebrafish. CELL DEATH AND DIFFERENTIATION 21:665-675(2014).
