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RPS6KA3

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 3

  • Overview

    The RSK or 90-kDa ribosomal S6 kinase family of proteins isa group of highly conserved Ser/Thr kinases that regulatediverse cellular processes during the growth factor mediatedstimulation of cell proliferation, survival anddifferentiation (1). In mammals, four RSK genes havebeen identified (RSK1, RSK2, RSK3 and RSK4), and the RSKisoforms are composed of two distinct and functionalkinase domains that are activated in a sequentialmanner by a series of phosphorylation events. RSKs aredownstream effectors of the Ras-extracellular signal regulatedkinase (ERK)/mitogen-activated protein kinase(MAPK) signalling cascade.
  • Synonyms

    RPS6KA3; ribosomal protein S6 kinase, 90kDa, polypeptide 3; CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3; ribosomal protein S6 kinase alpha-3; HU 3; RSK; RSK2; RSK-2; p90-RSK 3; MAPKAPK-1b; S6K-alpha-3; MAPKAP kinase 1b; ribosomal S6 kinase 2; MAPK-activated protein kinase 1b; insulin-stimulated protein kinase 1; MAP kinase-activated protein kinase 1b; CLS; HU-3; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RPS6KA3-153H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Insect Cell GST
Human RPS6KA3-154H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Insect Cell GST
Human RPS6KA3-155H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Insect Cell GST
Human RPS6KA3-221H Active Recombinant Human RPS6KA3(2-end) Protein, N-His-tagged Sf21 His 2-end
Human RPS6KA3-398H Recombinant Human RPS6KA3 Mammalian Cell His
Human RPS6KA3-30417TH Recombinant Human RPS6KA3 N/A
Human RPS6KA3-425H Recombinant Human RPS6KA3, GST-tagged, Active Sf9 Insect Cell GST
Human RPS6KA3-2161HCL Recombinant Human RPS6KA3 293 Cell Lysate HEK293 N/A
Human RPS6KA3-02H Recombinant Human RPS6KA3 Protein, His-tagged Insect Cells His
Human RPS6KA3-4011H-B Recombinant Human RPS6KA3 Protein Pre-coupled Magnetic Beads HEK293
Human RPS6KA3-1980HF Active Recombinant Full Length Human RPS6KA3 Protein, GST-tagged Insect (sf21) GST 1-740
Human RPS6KA3-0425H Recombinant Human RPS6KA3 protein, His-tagged E.coli His 666-740 aa
Human RPS6KA3-4011H Recombinant Human RPS6KA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RPS6KA3-1146H Recombinant Human RPS6KA3 Protein (Q400-L740), Tag Free E.coli No tag Q400-L740
Human RPS6KA3-1147H Recombinant Human RPS6KA3 Protein, Q400-L740, N-His tagged E.coli N-His Q400-L740
Mouse RPS6KA3-14495M Recombinant Mouse RPS6KA3 Protein Mammalian Cell His
Mouse RPS6KA3-7792M Recombinant Mouse RPS6KA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Rps6ka3-480M Recombinant Mouse Rps6ka3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse RPS6KA3-7792M-B Recombinant Mouse RPS6KA3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • RPS6KA3 Related Signal Pathway

RPS6KA3 involved in several pathways and played different roles in them. We selected most pathways RPS6KA3 participated on our site, such as MAPK signaling pathway, Oocyte meiosis, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPPM1BA;FGF16;RASA2;HSP70;HRAS;MAP2K1;MAPK3;FGF19;STK3
Oocyte meiosisRPS6KA2;CPEB4;PPP3CCA;CALM2;PPP2R5A;PPP1CC;AURKA;YWHABL;CAMK2D1
mTOR signaling pathwayPTENB;PDPK1B;RPS6KB1;EIF4E1B;IGF1;ULK2;PRKAA2;RRAGCB;HIF1A
Long-term potentiationGRIA2;PLCB3;BRAF;GRIN2B;PPP3R2;RPS6KA2;GRIN1;PRKACA;ATF4
Neurotrophin signaling pathwaySORT1;IRAK1;CAMK2B;ATF4;YWHAE;MAPK12;CALML5;FASLG;RPS6KA2
Progesterone-mediated oocyte maturationSPDYB;INS1;ANAPC13;HSP90AB1;MOS;IGF1RB;PRKACBA;Adcy4;PDE3B
Insulin resistancePTPN11;PRKAB1A;PPP1R3D;NR1H3;TBC1D4;SREBF1;PPP1R3B;CREB3L1;RELA

RPS6KA3 has several biochemical functions, for example, ATP binding, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA3 itself. We selected most functions RPS6KA3 had, and list some proteins which have the same functions with RPS6KA3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCHORDC1;AK9;HELQ;ABCF1;UBE2A;KIF27;RARS2;MELK;ACSL1
cysteine-type endopeptidase inhibitor activity involved in apoptotic processNAIP1;SNCA;MT3;DPEP1;BIRC2;ARRB1;VIL1;C1QL4L;PRDX3
magnesium ion bindingMAPK12;FARS2;CIB2;GCLC;HPGDS;RPS6KA3A;MAP3K6;ADSSL1;ADSS
protein bindingSPTLC1;MTDH;RPRD1A;CD2AP;KCTD17;ZKSCAN17;ACTB;KIF1C;TOP2A
protein kinase activityOXSR1A;MAP2K2A;RPS6KB1B;MAP4K1;PRKD2;STK30;PRPF4BB;RPS6KA3;CCL8
protein kinase bindingGOLGA2;PRKACA;TRIB3;LLGL1;MAML1;CENPJ;SPDYE2;NCS1;MAP3K13
protein serine/threonine kinase activityPKN2;RAF1B;STK38A;MAP2K4;FASTK;RPS6KA4;MAPKAPK2;GRK5;CDKL5
ribosomal protein S6 kinase activityRPS6KA3;RPS6KB1;RPS6KA2;RPS6KA6;RPS6KB1B;ALPK2;RPS6KA3A;RPS6KA4;RPS6KA3B

RPS6KA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA3.

MAPK1; saicar; MAPT; PKM; xmd8-92; biotin_acyl-p_probe; PDPK1; HSP90AB1; MCC; MAPK3; GSTK1; ATP5J; MASP1; SMS; CSNK2B; EIF3C; BARX1; Max

Research Area

Related articles

Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).
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