RPS6KA3

  • Official Full Name

    ribosomal protein S6 kinase, 90kDa, polypeptide 3
  • Overview

    The RSK or 90-kDa ribosomal S6 kinase family of proteins isa group of highly conserved Ser/Thr kinases that regulatediverse cellular processes during the growth factor mediatedstimulation of cell proliferation, survival anddifferentiation (1). In mammals, four RSK genes havebeen identified (RSK1, RSK2, RSK3 and RSK4), and the RSKisoforms are composed of two distinct and functionalkinase domains that are activated in a sequentialmanner by a series of phosphorylation events. RSKs aredownstream effectors of the Ras-extracellular signal regulatedkinase (ERK)/mitogen-activated protein kinase(MAPK) signalling cascade.
  • Synonyms

    RPS6KA3;ribosomal protein S6 kinase, 90kDa, polypeptide 3;CLS, Coffin Lowry syndrome , mental retardation, X linked 19 , MRX19, ribosomal protein S6 kinase, 90kD, polypeptide 3;ribosomal protein S6 kinase alpha-3;HU 3;RSK;RSK2;RSK-2;p90-RSK 3;MAPKAPK-1b;S6K-alpha-3;MAPKAP kinase 1b;ribosomal S6 kinase 2;MAPK-activated protein kinase 1b;insulin-stimulated protein kinase 1;MAP kinase-activated protein kinase 1b;CLS;HU-3;MRX19;ISPK-1;p90-RSK2;pp90RSK2;MAPKAPK1B;S6K-alpha3

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • Sf21 Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
RPS6KA3-0425H Recombinant Human RPS6KA3 protein, His-tagged E.coli Human His 666-740 aa
RPS6KA3-1147H Recombinant Human RPS6KA3 Protein, Q400-L740, N-His tagged E.coli Human His Q400-L740
RPS6KA3-153H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Cells Human GST
RPS6KA3-154H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Cells Human GST
RPS6KA3-155H Active Recombinant Human RPS6KA3, GST-tagged Sf9 Cells Human GST
RPS6KA3-14495M Recombinant Mouse RPS6KA3 Protein Mammalian Cells Mouse His
RPS6KA3-30417TH Recombinant Human RPS6KA3 Human Non Full L.
RPS6KA3-398H Recombinant Human RPS6KA3 Mammalian Cells Human His
RPS6KA3-425H Recombinant Human RPS6KA3, GST-tagged, Active Sf9 Cells Human GST
RPS6KA3-2161HCL Recombinant Human RPS6KA3 293 Cell Lysate HEK293 Human Non
RPS6KA3-02H Recombinant Human RPS6KA3 Protein, His-tagged Insect Cells Human His Full L.
RPS6KA3-1146H Recombinant Human RPS6KA3 Protein (Q400-L740), Tag Free E.coli Human Non Q400-L740
RPS6KA3-1980HF Active Recombinant Full Length Human RPS6KA3 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-740
RPS6KA3-4011H Recombinant Human RPS6KA3 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
RPS6KA3-4011H-B Recombinant Human RPS6KA3 Protein Pre-coupled Magnetic Beads HEK293 Human
Rps6ka3-480M Recombinant Mouse Rps6ka3 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
RPS6KA3-7792M Recombinant Mouse RPS6KA3 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
RPS6KA3-7792M-B Recombinant Mouse RPS6KA3 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RPS6KA3 involved in several pathways and played different roles in them. We selected most pathways RPS6KA3 participated on our site, such as MAPK signaling pathway,Oocyte meiosis,mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin resistance GFPT1,CREB3L1,AKT3A,NFKBIAB,CREB3L3,PPARGC1B,MTOR,INSRB,PTENA,SLC27A2
    mTOR signaling pathway PTENA,RRAGCB,PRKAA1,PRKCBA,RHEB,AKT1,PRKCG,RB1CC1,PRKCB,PDPK1
    MAPK signaling pathway FGF10A,PRKACBB,MAP2K4A,RAC2,PPM1A,ARRB2A,CACNA1SB,GADD45G,HSPA8,GRB2A
    Neurotrophin signaling pathway GAB1,CALM2,CALML5,BAD,SHC2,CAMK2D,NRAS,HRAS,CALML3,SH2B1
    Long-term potentiation MAPK1,ARAF,CALM1,CAMK2A,MAPK3,MAP2K1,CALML3,GRIN2D,CAMK4,GRM1
    Progesterone-mediated oocyte maturation MAPK11,PIK3R3B,CPEB2,RAF1B,RAF1,CCNB1,PPP1R2P9,CPEB1,ARAF,BUB1
    Oocyte meiosis PPP2R5D,CAMK2G1,PRKACBB,YWHAG1,CPEB4,CCNB2,PTTG2,PPP2R5B,ADCY1A,SGOL1

    Protein Function

    RPS6KA3 has several biochemical functions, for example, ATP binding,cysteine-type endopeptidase inhibitor activity involved in apoptotic process,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KA3 itself. We selected most functions RPS6KA3 had, and list some proteins which have the same functions with RPS6KA3. You can find most of the proteins on our site.

    Function Related Protein
    protein kinase activity PDK3,SIK2A,BUB1B,CAMK2G1,FYNB,TESK2,CSNK2A2A,GUCY2F,PRKACAB,KALRN
    magnesium ion binding NT5C3L,ZAK,PGM2,SIK3,ATP8B1,TSSK3,TSSK4,SRR,IDH3G,PGM1
    ribosomal protein S6 kinase activity RPS6KA4,RPS6KB1,RPS6KA1,RPS6KA3B,ALPK2,RPS6KA3A,RPS6KA6,RPS6KB2,RPS6KA2,RPS6KB1B
    protein serine/threonine kinase activity SIK2A,DCLK2,CSNK1G1,STRC,GRK1B,CSNK1D,CLK2,PLK1,CDC42BPG,PRKAA2
    ATP binding DDX11,MAP2K4,EHD1,HIPK3B,IRAK1,DGKG,CHD2,UBE2L3,GRK7,DDX56
    protein binding SCARA5,FCRL4,COPS5,INPP5D,SPATA13,DSTN,APOA4,NTF4,TRIM29,STOM
    protein kinase binding PTPN23,PTPN6,RCC2,GOLGA2,CALM2,CDC42,CEP152,CCNT2A,FOXO3,HDAC7
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process XIAP,AVP,SNCA,RPS6KA1,BIRC3,PRDX3,ARRB1,TFAP2B,VIL1,NAIP1

    Interacting Protein

    RPS6KA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KA3.

    MAPK1;saicar;MAPT;PKM;xmd8-92;biotin_acyl-p_probe;PDPK1;HSP90AB1;MCC;MAPK3;GSTK1;ATP5J;MASP1;SMS;CSNK2B;EIF3C;BARX1;Max

    RPS6KA3 Related Signal Pathway

    Resources

    References

    • Mierzejewska, K; Heo, J; et al. Genome-wide analysis of murine bone marrow-derived very small embryonic-like stem cells reveals that mitogenic growth factor signaling pathways play a crucial role in the quiescence and ageing of these cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 32:281-290(2013).

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