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SOS1

  • Official Full Name

    son of sevenless homolog 1 (Drosophila)

  • Overview

    This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
  • Synonyms

    SOS1; son of sevenless homolog 1 (Drosophila); GF1; HGF; NS4; GGF1; GINGF; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SOS1-1568HCL Recombinant Human SOS1 293 Cell Lysate HEK293 N/A
Human SOS1-13H Recombinant Human SOS1 Protein, His-tagged E.coli His
Human SOS1-38H Active Recombinant Human SOS1 Protein (564-1049), N-His tagged E.coli N-His 564-1049
Zebrafish SOS1-5322Z Recombinant Zebrafish SOS1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SOS1 Related Signal Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF7;FGF3;MAPKAPK2A;FLNA;ARRB2;FOS;DUSP3;PRKACG;MAP2K4
ErbB signaling pathwayERBB3B;CAMK2A;TGFA;HBEGFB;GSK3AA;AKT3A;AKT1;PLCG2;ABL1
Ras signaling pathwayEFNA4;RASSF5;HGF;FGFR3;GNGT2;PRKCG;GRIN1;GNG3;ANGPT2
Chemokine signaling pathwayARRB1;CX3CR1;AKT2;PRKCZ;PF4V1;NFKB1;PIK3R2;STAT1;Ccl21c
FoxO signaling pathwayNRAS;G6PCA.2;CCND2;TGFBR1A;MAPK8A;FOXO1A;HOMER2;IGF1R;AKT2L
Phospholipase D signaling pathwaySYK;SHC4;PIK3R3;TSC1;RALGDS;PLD1;DGKZ;PPAP2A;PLA2G4F
PIK-Akt signaling pathwayIL3RA;FGF7;FGF18;IL4;PHLPP2;TEK;GH2;TCL1B1;IFNA10
Dorso-ventral axis formationPIWIL2;NOTCH1;ETV6;MAPK3;GRB2B;PIWIL4;CPEB1B;PIWIL1;FMN2
Focal adhesionRAPGEF1B;THBS3;COL24A1;RHOAC;AKT2L;SHC1;FLNA;THBS1;CCND1
Gap junctionPRKACA;TUBA4A;DRD2L;PDGFD;GNA11;GRM5;GNA11B;TUBB1;TUBA2
Jak-STAT signaling pathwayPRLRA;PIAS1;PIK3R3B;FHL1A;STAT1A;RAF1B;MCL1A;LEP;STAT5B
Natural killer cell mediated cytotoxicitySHC4;NCR3;ITGAL;PPP3CB;LAT;IFNA8;FCGR3;MAPK1;RAC1
T cell receptor signaling pathwayPIK3CG;IFNG;MAPK11;CD3G;PRKCQ;DLG1;MAP3K7;CDC42;PIK3R2
B cell receptor signaling pathwayPPP3R1;NFATC2;ITK;CRKL;CD79B;NFKBIB;CDK2;TTC6;PPP3CA
Fc epsilon RI signaling pathwayFYN;MAPK11;MAPK9;PLA2G4F;IL5;PIK3R1;MAPK10;SYK;PIK3R3
Neurotrophin signaling pathwayCALML5;NTF3;SORT1;AKT2;TP53;KRAS;MAP3K1;BRAF;NTRK1
Regulation of actin cytoskeletonITGB4;ROCK2B;ARPC5L;ARPC5LA;FGFR4;PAK2A;APC;PIP5K1C;ITGA6
Insulin signaling pathwaySREBF1;PIK3CG;MKNK2B;INSRA;SOCS3B;HRASB;RAPGEF1B;CBLC;SOCS3
GnRH signaling pathwayCALM1;EGFRA;SRC;GNAS;CAMK2G;MAP2K1;PTK2BB;RAF1B;CACNA1DA
Estrogen signaling pathwayPIK3CA;HSPA8;SHC3;PLCB3;PIK3CG;OPRM1;GRM1;GNAI3;KCNJ9
Prolactin signaling pathwaySTAT1;SOCS5;ELF5;SHC4;KRAS;PIK3R5;SOCS2;MAPK8;SHC2
AlcoholismHIST1H2BA;HIST2H3C;DRD2;GM6026;FOSB;CREB3;HIST1H2BB;GNG11;SHC2
Hepatitis CRXRA;IFNA16;PIK3R1;EIF2AK4;IFNA14;CLDN1;IFNA1;IFNA6;Ifna11
Pathways in cancerFADD;ITGB1;GSTP1;MITF;MAP2K2;TGFB2;FOS;GNG7;GRB2
Proteoglycans in cancerERBB4;FZD2;IL12B;LUM;RPS6KB1;PLAUR;PLCG2;SDC4;MAPK13
MicroRNAs in cancerPDGFB;EP300;TPM1;ZFPM2;BCL2;CCNG1;PRKCG;SOX4;KRAS
Renal cell carcinomaTGFA;PAK7;TGFB3;CDC42;EGLN2;NRAS;PAK3;FH1;KRAS
Endometrial cancerBRAF;PIK3CA;FOXO3;HRAS;CASP9;MAP2K2;ARAF;CCND1;PTEN
GliomaCALM4;GRB2;HRAS;MAPK1;CALM1;MAP2K1;CALML5;CAMK2B;CAMK2G
Prostate cancerTCF7L2;SMARCC2;GRB2;Ar;NOXA1;PDGFA;LEF1;GSK3B;PIK3R3
Chronic myeloid leukemiaHDAC1;IKBKB;PIK3CD;HRAS;CDK6;BCL2L1;CBL;TGFBR1;RUNX1
Acute myeloid leukemiaTCF7L2;CEBPA;IKBKG;PIK3R2;ARAF;FLT3;MAPK1;TCF7;MAPK3
Non-small cell lung cancerNRAS;PRKCA;PIK3R2;RXRG;KRAS;STK4;PRKCB;BRAF;PLCG1
Choline metabolism in cancerRPS6KB1;PDGFD;PLA2G4B;RAC1;SLC22A1;PDGFRA;RPS6KB2;SLC44A2;SOS1

SOS1 has several biochemical functions, for example, DNA binding, GTPase activator activity, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function Related Protein
DNA bindingGM14479;NR4A2A;CERS4;HOXB13A;POU4F1;SSBP3B;TEAD2;HIST1H2BI;PPARDB
GTPase activator activitySMAP1;ARHGAP29;ARHGAP23;RGS9B;ELMOD2;ARHGAP27;SIPA1L2;ARHGDIG;TBC1D17
Ras guanyl-nucleotide exchange factor activityRASGEF1BA;SOS1;ADRB1;RAB3A;RGL2;RASGRP1;RAPGEF4;RASGEF1BB;RAPGEF5
Rho guanyl-nucleotide exchange factor activityFGD6;FARP1;ARHGEF40;FGD2;NET1;ARHGEF12;VAV3B;TIAM2;ABR
SH3 domain bindingQKI2;EVLB;CABYR;SH3BGRL2;CBL;ADAM17;ARHGAP31;ILK;SH3BP2
protein bindingDGAT1;NCOR2;VAMP4;CYFIP1;FKBP1B;UBAC1;NCBP1;PINX1;SNX9
protein heterodimerization activityPPP2R1A;CHRNB2;ABCG8;UBA3;TAS1R1;ITGB1;RRAGA;HIST2H4A;TCF3A

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2

  • Q&As
  • Reviews

Q&As (1)

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What is the volume of this reagent? 06/13/2023

The concentration of SOS1-13H is 1.0-2.0mg/ml. The volume can be calculated by the mass quantity and protein concentration.

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