SOS1

Official Full Name

son of sevenless homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Synonyms

SOS1;son of sevenless homolog 1 (Drosophila);GF1;HGF;NS4;GGF1;GINGF;son of sevenless homolog 1;SOS-1;guanine nucleotide exchange factor;gingival fibromatosis, hereditary, 1

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
SOS1-5322Z	Recombinant Zebrafish SOS1	Mammalian Cells	Zebrafish	His		Inquiry
SOS1-1568HCL	Recombinant Human SOS1 293 Cell Lysate	HEK293	Human	Non		Inquiry
SOS1-13H	Recombinant Human SOS1 Protein, His-tagged	E.coli	Human	His	563-1049 a.a.	Inquiry
SOS1-38H	Active Recombinant Human SOS1 Protein (564-1049), N-His tagged	E.coli	Human	His	564-1049	Inquiry

Involved Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Estrogen signaling pathway	GNAI2,OPRM1,NRAS,SHC4,PIK3R2,PLCB3,HSPA1B,HRAS,ESR2,CREB5
MAPK signaling pathway	TGFBR1A,FLNA,TAOK3,HRASA,TGFBR1B,CACNB1,GADD45BB,RAC1B,NFKB2,TRAF6
Pathways in cancer	BRAF,TCF7,FGF11,NOS2,IGF1,BCL2,Shh,BMP2,FADD,FZD9
Fc epsilon RI signaling pathway	MAPK12,RAF1,PIK3R2,MAPK1,PIK3CG,PIK3R1,MAPK8,MAP2K4,LAT,PLA2G4C
Renal cell carcinoma	TCEB2,PAK1,PIK3R1,TGFB2,MAP2K1,PIK3R2,PIK3R3,FH1,HIF1A,FLCN
Neurotrophin signaling pathway	CAMK2A,MAP2K7,PIK3R1,MAPKAPK2,ARHGDIA,RIPK2,MAPK1,MAPK8,ATF4,GRB2
Chemokine signaling pathway	PRKCZ,CCL3L3,PIK3R1,GNAI3,CCL19,PIK3CD,GNG10,RAP1A,JAK2,CCR7
Proteoglycans in cancer	WNT4,PPP1CA,PPP1R12A,MET,TWIST2,TLR2,AKT2,CTTN,PIK3CA,PDPK1
Hepatitis C	MAPK13,NFKBIA,IFNA6,DDX58,CLDN4,CLDN20,PIK3CA,IRF7,Ifna15,IFNA12

Protein Function

SOS1 has several biochemical functions, for example, DNA binding,GTPase activator activity,Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	BRPF1,ZNF177,PIF1,GSX2,POLR2J,HOXB8B,PRRX1A,STAT2,POLR1D,CHD2
GTPase activator activity	JUN,WNT11,GIT2,ARRB1,AGAP2,DOCK1,DOCK4,ARHGDIA,ASAP3,ARHGAP25
Rho guanyl-nucleotide exchange factor activity	ARHGEF9B,ARHGEF10,ARHGEF39,NET1,ARHGEF12,FGD2,BCR,MCF2L,ARHGEF7,KALRN
protein binding	FAM113B,MAGEB18,CCND2,FLT1,THBS4,IRX1,TTYH2,NTF4,BCAS2,ZMYND19
SH3 domain binding	BCAR1,ADAM19,CIT,INPPL1,ADAM17,SH3BP5,PDE4D,KHDRBS1,PTTG2,PTPN22
protein heterodimerization activity	PHC2B,TYRO3,CUL5,Itgam&Itgb2,FZD1,H2AFJ,Pdgfa&Pdgfb,CA,BAXA,POLA1
Ras guanyl-nucleotide exchange factor activity	RAB3A,RASGRP4,ADRB1,RASGEF1BA,RGL2,RASGEF1BB,RASGRP3,KNDC1,RASGRP1,RAPGEF5

Interacting Protein

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2