STRADA
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Official Full Name
STE20-related kinase adaptor alpha -
Overview
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. -
Synonyms
STRADA;STE20-related kinase adaptor alpha;STE20-related kinase adapter protein alpha;LYK5;NY BR 96;STE20 like pseudokinase;Stlk;STRAD;STRAD alpha;protein kinase LYK5;STE20-like pseudokinase;serologically defined breast cancer antigen NY-BR-96
Recombinant Proteins
- Zebrafish
- Chicken
- Human
- Rat
- Mammalian Cells
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- GST
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| STRADA-10280Z | Recombinant Zebrafish STRADA | Mammalian Cells | Zebrafish | His |
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| STRADA-2068C | Recombinant Chicken STRADA | Mammalian Cells | Chicken | His |
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| STRADA-229H | Recombinant Human STRADA, His-tagged | E.coli | Human | His | 1-314aa |
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| STRADA-449H | Recombinant Human STRADA Protein, His-tagged | E.coli | Human | His |
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| STRADA-5804R | Recombinant Rat STRADA Protein | Mammalian Cells | Rat | His |
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| STRADA-1041HCL | Recombinant Human STRADA cell lysate | Human | Non |
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| STRADA-4560H | Recombinant Human STRADA Protein, GST-tagged | Wheat Germ | Human | GST |
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| STRADA-5463R | Recombinant Rat STRADA Protein, His (Fc)-Avi-tagged | HEK293 | Rat | Avi&Fc&His |
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| STRADA-5463R-B | Recombinant Rat STRADA Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| STRADA-6235HF | Recombinant Full Length Human STRADA Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 348 amino acids |
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Involved Pathway
STRADA involved in several pathways and played different roles in them. We selected most pathways STRADA participated on our site, such as mTOR signaling pathway,AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mTOR signaling pathway | RPS6KB2,ULK1,PTENA,EIF4BA,PRKCA,MAPK3,IGF1,INS,BRAF,RPTOR |
| AMPK signaling pathway | PFKFB2,EEF2,PFKFB3,ADRa1A,PIK3R5,PIK3CD,PCK2,PPP2CA,PRKAA2,RPTOR |
Protein Function
STRADA has several biochemical functions, for example, ATP binding,NOT Rac GTPase binding,kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADA itself. We selected most functions STRADA had, and list some proteins which have the same functions with STRADA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | RHOBTB3,CAMK1G,XRCC5,CLCN4,GRK5,ADCY6,RIPK1,ATP1A1B,CLK3,SARS2 |
| NOT Rac GTPase binding | STRADB |
| NOT protein serine/threonine kinase activity | SNX15,STRADB,FAM20A |
| NOT protein kinase activity | HSPB8,PXK,STRADB,TRIB2,TRIB1,MLKL |
| protein serine/threonine kinase activator activity | PARP16,CALM2,LTF,FAM20A,CDK5R1,ALS2,CALM3,MAP2K1,CALM1,MAP2K2 |
| protein kinase activator activity | DBF4B,CAB39,NKX3-1,MARK2,PRKAG2,GPRC5B,PIK3CA,DAXX,NKX3,TOM1L1 |
| protein binding | HSPBP1,SLAMF1,DSTN,NLRP1,APOD,SPTSSB,PCBD1,ZNF193,EIF4A3,HELT |
| kinase binding | LDHA,STUB1,PFKM,TRIP6,FAS,TENC1,JAKMIP3,LDHB,WWC2,ABI2 |
Interacting Protein
STRADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADA here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADA.
STK11;CAB39
STRADA Related Signal Pathway
Resources
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References
- Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).
- Sugden, PH; McGuffin, LJ; et al. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. BIOCHEMICAL JOURNAL 454:13-30(2013).
