• Official Full Name
  • STE20-related kinase adaptor alpha
  • Background
  • The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known.
  • Synonyms
  • STRADA; STE20-related kinase adaptor alpha; STE20-related kinase adapter protein alpha; LYK5; NY BR 96; STE20 like pseudokinase; Stlk; STRAD; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human STRADA Protein, GST-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STRADA, His-tagged
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STRADA Protein, His-tagged
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STRADA Protein
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STRADA
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STRADA
Source (Host):Species:Human
Product nameRecombinant Human STRADA cell lysate

STRADA Related Articles

Veleva-Rotse, BO; Smart, JL; et al. STRAD pseudokinases regulate axogenesis and LKB1 stability. NEURAL DEVELOPMENT 9:-(2014).
Sugden, PH; McGuffin, LJ; et al. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. BIOCHEMICAL JOURNAL 454:13-30(2013).