STRADA
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Official Full Name
STE20-related kinase adaptor alpha
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Overview
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a pseudokinase. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. -
Synonyms
STRADA; STE20-related kinase adaptor alpha; STE20-related kinase adapter protein alpha; LYK5; NY BR 96; STE20 like pseudokinase; Stlk; STRAD; STRAD alpha; protein kinase LYK5; STE20-like pseudokinase; serologically defined breast cancer antigen NY-BR-96;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | STRADA-449H | Recombinant Human STRADA Protein, His-tagged | E.coli | His | ||
Human | STRADA-229H | Recombinant Human STRADA, His-tagged | E.coli | His | 1-314aa | |
Human | STRADA-1041HCL | Recombinant Human STRADA cell lysate | N/A | |||
Human | STRADA-6235HF | Recombinant Full Length Human STRADA Protein, GST-tagged | In Vitro Cell Free System | GST | 348 amino acids | |
Human | STRADA-4560H | Recombinant Human STRADA Protein, GST-tagged | Wheat Germ | GST | ||
Rat | STRADA-5804R | Recombinant Rat STRADA Protein | Mammalian Cell | His | ||
Rat | STRADA-5463R | Recombinant Rat STRADA Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | STRADA-5463R-B | Recombinant Rat STRADA Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | STRADA-10280Z | Recombinant Zebrafish STRADA | Mammalian Cell | His | ||
Chicken | STRADA-2068C | Recombinant Chicken STRADA | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- STRADA Related Articles
- STRADA Related Signal Pathway
STRADA involved in several pathways and played different roles in them. We selected most pathways STRADA participated on our site, such as mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STRADA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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mTOR signaling pathway | PDPK1B;RPS6KA2;TNF;EIF4E2;RHEB;RICTOR;ULK3;AKT2L;PRKAA2 |
AMPK signaling pathway | PRKAB2;CAB39L;Scd1;CCNA2;RAB2A;CREB3;PIK3R2;INSR;FBP2 |
STRADA has several biochemical functions, for example, ATP binding, NOT Rac GTPase binding, kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STRADA itself. We selected most functions STRADA had, and list some proteins which have the same functions with STRADA. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | ABCG2;HELB;FGFR1B;P2RX3;DAK;UBA3;CHD2;ACTR3B;LATS2 |
NOT Rac GTPase binding | STRADB;STRADA |
kinase binding | FAS;PPP2R5A;ATF5;TNFAIP3;HSP90AB1;DLG4;RPS3;BCL10;DLG3 |
protein binding | MTTP;ARHGAP1;PPEF1;DGKQ;P4HA3;MATN1;EIF5;TDRD7;ELMOD3 |
protein kinase activator activity | PRKAG2;FGF13;WNT11;EPO;DUSP19;MAPK8IP2;FAM58A;CAB39;GPRC5B |
NOT protein kinase activity | TRIB1;TRIB2;STRADB;HSPB8;STRADA;PXK;MLKL |
protein serine/threonine kinase activator activity | STK3;FAM20A;CDK5R1;SPRY2;STRADA;STK4;LTF;CALM2;CALM3 |
NOT protein serine/threonine kinase activity | STRADB;FAM20A;SNX15;STRADA |
STRADA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STRADA here. Most of them are supplied by our site. Hope this information will be useful for your research of STRADA.
STK11; CAB39
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