TAF1 Protein

TAF1

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TAF1

Official Full Name TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
Background Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
Synonyms TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S;
    • Species :
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • Flag
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TAF1-122H Recombinant Human TAF1, GST-tagged E.coli GST
    Human TAF1-165H Recombinant Human TAF1, GST-tagged E.coli GST
    Human TAF1-213H Recombinant Human TAF1 Protein, GST-tagged E.coli GST
    Human TAF1-214H Recombinant Human TAF1 Protein, His-tagged E.coli His
    Human TAF1-215H Recombinant Human TAF1 Protein, GST-tagged E.coli GST
    Human TAF1-216H Recombinant Human TAF1 Protein, His-tagged E.coli His
    Human TAF1-222H Recombinant Human TAF1 Protein, His-tagged E.coli His
    Human TAF1-6954H Recombinant Human TAF1, GST-tagged Sf9 Insect Cell GST
    Human TAF1-78H Recombinant Human TAF1, His&FLAG-tagged E.coli His/Flag
    Human TAF1-79H Recombinant Human TAF1, His&FLAG-tagged E.coli His/Flag
    Zebrafish TAF1-3927Z Recombinant Zebrafish TAF1 Mammalian Cell His
    Kit-1873 TAF1 (BD1/BD2) Inhibitor Screening Assay Kit N/A
    Kit-2032 TAF1 bromodomain 1 TR-FRET Assay Kit N/A
    Kit-2033 TAF1 bromodomains 1 and 2 TR-FRET Assay Kit N/A

    TAF1 involved in several pathways and played different roles in them. We selected most pathways TAF1 participated on our site, such as Basal transcription factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Basal transcription factors TAF7; TAF3; TAF4B; TAF10; TAF15; GTF2H2; GTF2H4; TAF12; TBPL1; GTF2E2

    TAF1 has several biochemical functions, for example, ATP binding, TBP-class protein binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF1 itself. We selected most functions TAF1 had, and list some proteins which have the same functions with TAF1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TP53; STYK1; ACSL1; KIF2C; UBE2A; ETNK1; PSMC5; EIF4A1A; YME1L1B; CSNK2A2
    TBP-class protein binding PSMC6; DR1; GTF2A1; PSMC2; TAF1; CAND2; HHEX; GTF2A2; PSMC5; BRF1B
    histone acetyltransferase activity METTL8; KAT7A; NCOA2; GTF3C4; KAT6B; KAT5; TAF1; CSRP2BP; KAT2A; KAT6A
    lysine-acetylated histone binding BAZ1B; BRD2; TAF1L; BRD9; TRIM24; PSME4; BAZ2A; SMARCA4; BRD3; BRD7
    p53 binding RFFL; SETD8; TRP63; PTTG1IP; TP73; ZNF385C; SETD7; CHD8; STK11; TP53RK
    protein binding NSMAF; CBX5; PROCR; DNAI1; SLC22A5; GLRX3; CASK; PTPN22; RALY; ATF5
    protein serine/threonine kinase activity PRKCDA; STK32C; TSSK3; PKMYT1; STK17A; LRRK2; MYO3A; SGK2; CAMK2D; ALPK1
    sequence-specific DNA binding NR3C2; RARGA; FOXG1B; NKX1.2LA; DBX1; SNAI2; FOXC1; EMX2; MYOG; NKX2-5
    transcription coactivator activity JUPA; TAF7; TAF6L; PML; CEBPA; ARID1A; NCOA4; HSF2; SIX3; THRAP3
    transcription factor binding APBB2; HDAC2; KCTD1; DIP2C; ZBTB49; ESRRB; PURA; IGHMBP2; ATOH8; UBE2I
    contributes_to transcription regulatory region DNA binding NR1H3; TAF1; HAND1; NFYC; NFYB; HDAC4; ATF4; TCF12; NFYA; TCF3

    TAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF1.

    TBP; e1a_ade05; GTF2F1; E2; E2; rpl31_human_gene; rl34_human_gene; rps10_human_gene; RB1; DYSF; DNAJB5

    Sako, W; Morigaki, R; et al. IDENTIFICATION AND LOCALIZATION OF A NEURON-SPECIFIC ISOFORM OF TAF1 IN RAT BRAIN: IMPLICATIONS FOR NEUROPATHOLOGY OF DYT3 DYSTONIA. NEUROSCIENCE 189:100-107(2011).
    Bergstralh, DT; Conti, BJ; et al. Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. EXPERIMENTAL CELL RESEARCH 313:65-76(2007).
    Tseng, L; Tang, MY; et al. Progesterone receptor (hPR) upregulates the fibronectin promoter activity in human decidual fibroblasts. DNA AND CELL BIOLOGY 22:633-640(2003).

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