TAF1

  • Official Full Name

    TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

  • Overview

    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]
  • Synonyms

    TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S;

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  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • TAF1 Related Articles
  • TAF1 Related Research Area

TAF1 involved in several pathways and played different roles in them. We selected most pathways TAF1 participated on our site, such as Basal transcription factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Basal transcription factorsCCNH;TAF6L;TAF6;TAF8;CDK7;GTF2F2A;GTF2F1;TAF10;TAF1

TAF1 has several biochemical functions, for example, ATP binding, TBP-class protein binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF1 itself. We selected most functions TAF1 had, and list some proteins which have the same functions with TAF1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingATAD3A;CDK16;GLULB;ROR2;ATP2C1;EPHA4B;ROCK2;STK25A;UBE2Z
TBP-class protein bindingPSMC1B;PSMC1;EFCAB11;THRA;GTF2A1;TAF1L;TAF1;TAF1B;DR1
histone acetyltransferase activityTAF1L;KAT2B;MED24;NCOA2;KAT7B;EP300;CDYL;NCOA1;METTL8
lysine-acetylated histone bindingPHIP;BRD4;MLL1;BRD2;ATAD2B;PSME4B;BRDT;BAZ1B;BRD3
p53 bindingNTRK3;HTT;ZNF385A;MAPKAPK5;TRIAP1;BRD7;HSPD1;SIRT1;TRIM24
protein bindingSH3PXD2A;C1QTNF3;CACNG1;USP34;COL6A5;GTF2H3;THAP7;RNH1;ZNF205
protein serine/threonine kinase activityMELK;RPS6KA3B;SIK2;AURKA;DAPK3;CDK11B;AURKB;PRPF4B;MARK4
sequence-specific DNA bindingOTP;FOXO1A;ZSCAN12;TFAP2A;PBX2;RXRGB;SREBF1;ATF5;TAF1
transcription coactivator activityATXN7L3;CREBBP;BRCA1;JUNB;SMARCC2;ATF2;WWC1;COPS5;MAGED1
transcription factor bindingGTF2A1;NCOA2;IFI203;FOS;ARRB1;HDAC3;APBB1;JUNBB;FIGLA
contributes_to transcription regulatory region DNA bindingRXRA;NR1H3;HDAC4;NFYB;HAND1;NFYA;TCF12;HDAC5;TCF3

TAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF1.

TBP; e1a_ade05; GTF2F1; E2; E2; rpl31_human_gene; rl34_human_gene; rps10_human_gene; RB1; DYSF; DNAJB5

Sako, W; Morigaki, R; et al. IDENTIFICATION AND LOCALIZATION OF A NEURON-SPECIFIC ISOFORM OF TAF1 IN RAT BRAIN: IMPLICATIONS FOR NEUROPATHOLOGY OF DYT3 DYSTONIA. NEUROSCIENCE 189:100-107(2011).
Bergstralh, DT; Conti, BJ; et al. Global functional analysis of nucleophosmin in Taxol response, cancer, chromatin regulation, and ribosomal DNA transcription. EXPERIMENTAL CELL RESEARCH 313:65-76(2007).
Tseng, L; Tang, MY; et al. Progesterone receptor (hPR) upregulates the fibronectin promoter activity in human decidual fibroblasts. DNA AND CELL BIOLOGY 22:633-640(2003).
  • Q&As
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Q&As (7)

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What are the mechanisms by which TAF1 modulates the expression of specific sets of genes? 11/17/2022

TAF1 specifically modulates the expression of certain genes, impacting diverse cellular functions and processes.

How does TAF1 (TATA-Box Binding Protein Associated Factor 1) regulate transcription initiation by RNA polymerase II? 05/03/2022

TAF1 is pivotal in initiating transcription by RNA polymerase II, regulating the early steps of gene expression.

How does TAF1 contribute to the regulation of gene expression in response to cellular signals and stress? 09/30/2021

TAF1 responds to cellular signals and stress, adapting gene expression to meet cellular needs and challenges.

How does TAF1 influence chromatin remodeling and accessibility of DNA for transcription? 04/21/2021

TAF1 plays a role in chromatin remodeling, making DNA accessible for transcription and regulating gene activity.

How do alterations in TAF1 expression or function affect the cell cycle and apoptosis? 03/11/2019

Changes in TAF1 can influence key cellular processes like the cell cycle and programmed cell death.

What role does TAF1 play in the assembly and function of the transcription factor IID (TFIID) complex? 08/05/2018

TAF1 is integral to the TFIID complex, essential for accurate and efficient transcription initiation.

What is the impact of TAF1 mutations on neurodevelopmental disorders and intellectual disabilities? 02/06/2018

Mutations in TAF1 are linked to neurodevelopmental disorders, affecting brain development and function.

Customer Reviews (3)

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Reviews
10/20/2021

    Expertise in peptide synthesis, accelerates our peptide-based research.

    04/15/2019

      Swift protein quantification, improves data reliability in our work.

      11/26/2018

        Reliable protein crystallography, key for our structural biology research.

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