|Official Full Name||TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa|
|Background||Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences encompassing the transcription start site. It also binds to activators and other transcriptional regulators, and these interactions affect the rate of transcription initiation. This subunit contains two independent protein kinase domains at the N- and C-terminals, but also possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Mutations in this gene result in Dystonia 3, torsion, X-linked, a dystonia-parkinsonism disorder. Alternative splicing of this gene results in multiple transcript variants. This gene is part of a complex transcription unit (TAF1/DYT3), wherein some transcript variants share exons with TAF1 as well as additional downstream DYT3 exons. [provided by RefSeq, Oct 2013]|
|Synonyms||TAF1; TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa; OF; XDP; BA2R; CCG1; CCGS; DYT3; KAT4; P250; NSCL2; TAF2A; N-TAF1; TAFII250; DYT3/TAF1; TAFII-250; TAF(II)250; transcription initiation factor TFIID subunit 1; cell cycle gene 1 protein; cell cycle, G1 phase defect; TBP-associated factor 250 kDa; transcription factor TFIID p250 polypeptide; complementation of cell cycle block, G1-to-S;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
TAF1 involved in several pathways and played different roles in them. We selected most pathways TAF1 participated on our site, such as Basal transcription factors, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Basal transcription factors||TAF11; TBPL2; GTF2H2; TAF7; TAF1; MNAT1; GTF2H1; TAF13; TAF4B; GTF2I|
TAF1 has several biochemical functions, for example, ATP binding, TBP-class protein binding, histone acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TAF1 itself. We selected most functions TAF1 had, and list some proteins which have the same functions with TAF1. You can find most of the proteins on our site.
|ATP binding||PRKCB; P2RX5; FASTK; ROCK2A; DTYMK; VRK2; STK25B; CAMK1; UBE2KB; SRPK2|
|TBP-class protein binding||PSMC5; GTF2A1; PSMC3; PSMC1A; DR1; CAND2; THRA; BRF1A; TAF1L; BRF1B|
|histone acetyltransferase activity||KAT7; TAF1L; TAF1; METTL8; KAT8; NCOA2; NCOA3; MGEA5; CREBBP; HAT1|
|lysine-acetylated histone binding||PHIP; ATAD2B; SMARCA4; BRD9; BRDT; BAZ2A; BRD3; TRIM24; MLL1; TAF1|
|p53 binding||ZNF385B; ZNF385A; TP73; BLM; BRD4; MDM2; ZNF346; ZNF385D; MSX1; ZMAT4|
|protein binding||SPAG5; GET4; AP2A2; PRPF8; TRIM38; FAM40A; PHB2; GOLSYN; CCDC93; HELZ|
|protein serine/threonine kinase activity||DCAMKL2; MAP2K5; LMTK3; SYK; cka1; RAF1A; SGK2; CLK4; ALPK2; SLC14A2|
|sequence-specific DNA binding||LMX1A; FOXD1L; ESX1; HOXC6; HOXA4; HOXD11; HOXC6A; DMRT3; FOXO3A; CREB3L1|
|transcription coactivator activity||ECD; DDX5; SCAND1; PMF1; RB1; KAT2A; KDM5A; SERTAD2; CITED4; SMARCE1|
|transcription factor binding||TBX5; SUFU; PAXBP1; CRY1; RBL1; TMEM173; HES6; HMGB2; PPP1R13BA; GATA6|
|contributes_to transcription regulatory region DNA binding||HAND1; TCF12; NFYA; NFYC; TCF3; RXRA; NFYB; HDAC4; ATF4; HDAC5|
TAF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAF1.
TBP; e1a_ade05; GTF2F1; E2; E2; rpl31_human_gene; rl34_human_gene; rps10_human_gene; RB1; DYSF; DNAJB5